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Cognitive impairment in cervical dystonia: core clinical feature or secondary effect related to non-motor symptoms?
[AIM OF THE STUDY] To investigate subtle cognitive dysfunction in patients with cervical dystonia (CD) as a potential independent non-motor feature of the disease or as a consequence of interactions between motor and other non-motor symptom…
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GDF15 - A potential novel biomarker of cognitive impairment in cervical dystonia.
[INTRODUCTION] Cervical dystonia (CD) is a chronic movement disorder characterized by motor symptoms and a spectrum of non-motor features, including cognitive difficulties, which may affect quality of life. To date, no biomarker exists to i…
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Neurophysiological assessment of F-, M-waves and cutaneous silent period in patients with caput patterns of cervical dystonia in the waning phase of botulinum toxin therapy.
[AIM OF THE STUDY] Evaluate and compare F‑wave and cutaneous silent period (CSP) parameters in caput‑pattern idiopathic cervical dystonia (CD) in the waning phase of botulinum toxin therapy vs. healthy controls to identify alterations in se…
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Does botulinum toxin type A treatment influence non-motor symptoms in cervical dystonia patients? A systematic review.
The effect of botulinum toxin A (BoNTA) on non-motor symptoms (NMS) in patients with cervical dystonia remains an area of significant clinical interest, given the profound impact of these symptoms on patients' quality of life. While the the…
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Is There a "Non-Motor Effect" of Botulinum Toxin Treatment in Cervical Dystonia in Addition to Its Effects on Motor Symptoms?
The efficacy of botulinum toxin A (BoNT) in alleviating motor symptoms of cervical dystonia (CD) has been well established, and it is the treatment of choice in this disease. Lately, the effect of BoNT on non-motor symptoms (NMS) such as co…
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Functional Effects of BoNT-A Application in Masseter Muscle in Patients with Symptoms of Bruxism.
Bruxism, defined as a repetitive jaw-muscle activity characterized by clenching or grinding of teeth and/or by bracing or thrusting of the mandible, is a prevalent behavior affecting up to 22% of adults worldwide. While traditionally viewed…
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Neurophysiological Assessment of F-Wave, M-Wave, and Cutaneous Silent Period in Patients with Caput-Pattern Cervical Dystonia at Waning and Peak Response Phases of Botulinum Toxin Therapy.
While distinguishing between collis and caput patterns in cervical dystonia (CD) has clear clinical and therapeutic relevance, the effects of botulinum toxin type A (BoNT-A) on segmental spinal excitability and inhibitory function in caput-…
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Dose per muscle in cervical dystonia: pooled data from seven movement disorder centres.
[AIM OF STUDY] Botulinum neurotoxin type A (BoNT/A) injections are the established treatment in cervical dystonia (CD). But clinical practice regarding the choice of muscles into which injections are made varies between centres. Until now, …
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Botulinum toxin type-A preparations are not the same medications - basic science (Part 1).
Botulinum neurotoxin type A (BoNT/A) formulations are widely used in clinical practice. Although they share a common mechanism of action resulting in presynaptic block in acetylocholine release, their structure and pharmacological propertie…
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Botulinum toxin type-A preparations are not the same medications - clinical studies (Part 2).
The growing number of Botulinum neurotoxin type A (BoNT/A) preparations on the market has resulted in a search for pharmacological, clinical and pharmacoeconomic differences. Patients are occasionally switched from one botulinum toxin formu…
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Frequency of different subtypes of cervical dystonia: a prospective multicenter study according to Col-Cap concept.
Patients with cervical dystonia (CD) may present with head and/or neck movements in the coronal, sagittal or transverse plane. According to the Col-Cap concept, CD postures are classified in torti-, latero-, ante- and retrocollis/caput patt…
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Real-world effectiveness of abobotulinumtoxinA (Dysport®) in adults with upper limb spasticity in routine clinical practice: an observational study.
AbobotulinumtoxinA (aboBoNT-A, Dysport®) is used in clinical practice as a well-tolerated and effective therapy for muscle spasticity. AboBoNT-A has been shown to reduce upper and lower limb spastic paresis in clinical trials, demonstrating…
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Tremor in Idiopathic Cervical Dystonia - Possible Implications for Botulinum Toxin Treatment Considering the Col-Cap Classification.
[BACKGROUND] Tremor is an important phenotypic feature of dystonia. Using the new concept (Col-Cap) of classification we examined the frequency of tremor in cervical dystonia (CD) patients, their main subtypes and muscles injected. [METHOD…