Botulinum toxin type-A preparations are not the same medications - basic science (Part 1).

Neurologia i neurochirurgia polska 2021 Vol.55(2) p. 133-140

Car H, Bogucki A, Bonikowski M, Dec-Ćwiek M, Drużdż A, Koziorowski D, Rudzińska-Bar M, Sarzyńska-Długosz I, Sławek J

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Abstract

Botulinum neurotoxin type A (BoNT/A) formulations are widely used in clinical practice. Although they share a common mechanism of action resulting in presynaptic block in acetylocholine release, their structure and pharmacological properties demonstrate some similarities and many differences. Bioequivalence has been discussed since the onset of the clinical use of BoNT/A. In this review, we provide an update on the studies and compare the molecular structure, mechanisms of action, diffusion and spread, as well as immunogenicity and dose equivalence of onabotulinumtoxinA, abobotulinumtoxinA and incobotulinumtoxinA.

추출된 의학 개체 (NER)

유형영어 표현한국어 / 풀이UMLS CUI출처등장
시술 botulinum toxin 보툴리눔독소 주사 dict 1

MeSH Terms

Botulinum Toxins, Type A; Humans

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