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Unusual delayed and prolonged arm weakness and atrophy following botulinum toxin injection for musician's cramp: case report.
Botulinum toxin is considered first-line treatment for focal hand dystonia in musicians. Mild, temporary weakness is a common accompaniment of effective injection. We present a unique case of delayed-onset, severe, prolonged weakness and at…
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Hand and distal joint tremor are most coherent with the activity of elbow flexors and wrist extensors in persons with essential tremor.
Essential tremor (ET) affects millions of people. Although frontline treatment options (medication, deep brain stimulation, and focused ultrasound ablation) have provided significant relief, many patients are unsatisfied with the outcomes. …
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Clinical neurophysiology in the treatment of movement disorders: IFCN handbook chapter.
In this review, different aspects of the use of clinical neurophysiology techniques for the treatment of movement disorders are addressed. First of all, these techniques can be used to guide neuromodulation techniques or to perform therapeu…
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Comparison of Ultrasound and Electrical Stimulation Guidance for Onabotulinum Toxin-A Injections: A Randomized Crossover Study.
[BACKGROUND] Botulinum neurotoxin (BoNT) injection is an established therapy for limb spasticity and focal limb dystonia. Comparative benefits of injection guidance procedures have not been rigorously studied. [OBJECTIVES] We compared 2 ta…
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Scar Dancing Syndrome: Peripheral Trauma Induced Involuntary Hyperkinesia around Surgical Incision.
[BACKGROUND] Peripherally induced movement disorders represent a rare and debated complication of peripheral trauma. It is difficult to determine a causal relationship between peripheral injuries and subsequent movement disorders. [CASES] …
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MDS evidence-based review of treatments for essential tremor.
[BACKGROUND] Essential tremor is one of the most prevalent movement disorders. Many treatments for essential tremor have been reported in clinical practice, but it is uncertain which options have the most robust evidence. The International …
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Botulinum toxin and occupational therapy for Writer's cramp.
[BACKGROUND] Writer's cramp (WC) is a form of focal hand dystonia, for which focal botulinum neurotoxin (BoNT) injections are the current best therapy. Past studies have shown that some types of rehabilitative therapy can be useful. We hypo…
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Electromyographic and Joint Kinematic Patterns in Runner's Dystonia.
Runner’s dystonia (RD) is a task-specific focal dystonia of the lower limbs that occurs when running. In this retrospective case series, we present surface electromyography (EMG) and joint kinematic data from thirteen patients with RD…
- Combined effects of rTMS and botulinum toxin therapy in benign essential blepharospasm.
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Longitudinal studies of botulinum toxin in cervical dystonia: Why do patients discontinue therapy?
[BACKGROUND] Numerous studies have established botulinum toxin (BoNT) to be safe and effective for the treatment of cervical dystonia (CD). Despite its well-documented efficacy, there has been growing awareness that a significant proportion…
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Research Priorities in Limb and Task-Specific Dystonias.
Dystonia, which causes intermittent or sustained abnormal postures and movements, can present in a focal or a generalized manner. In the limbs, focal dystonia can occur in either the upper or lower limbs and may be task-specific causing abn…
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Positional Tremor and its Treatment.
[BACKGROUND] Positional tremors arise when a patient's tremor is brought on during specific positioning of the involved body part. They can be distinguished from postural tremor, wherein a patient's tremor is elicited in any posture, and fr…
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Differences in active range of motion measurements in the upper extremity of patients with writer's cramp compared with healthy controls.
[STUDY DESIGN] Exploratory case-control study. [INTRODUCTION] Writer's cramp (WC) is a type of focal hand dystonia. The central nervous system plays a role in its pathophysiology, but abnormalities in the affected musculoskeletal component…
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Gene expression signatures of morphologically normal breast tissue identify basal-like tumors.
[INTRODUCTION] The role of the cellular microenvironment in breast tumorigenesis has become an important research area. However, little is known about gene expression in histologically normal tissue adjacent to breast tumor, if this is infl…