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12건 · 최신순-
Computational modelling the impact of GLP-1 receptor agonists on botulinum toxin A: Evidence for reduced treatment durability across neurologic and aesthetic indications.
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have transformed metabolic and aesthetic medicine, yet their potential influence on botulinum toxin type A (BoNT-A) pharmacodynamics remains unexplored. Using the AesthetiSIM™ microsimul…
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Computational model-informed comparative evaluation of botulinum toxin a formulations: A 20-year simulation of onset, diffusion, duration, and immunogenicity.
Comparative evaluation of botulinum neurotoxin type A (BoNT/A) formulations is limited by short clinical trials and lack of long-term safety data. This study applied a validated multiscale computational model (AesthetiSIM™) to simulate 20 y…
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Excipient substitution in botulinum toxin type A formulations: Insights from multi-scale in silico modelling.
Botulinum neurotoxin type A (BoNT/A) formulations differ mainly in excipients, which determine stability, aggregation, and diffusion. Using multi-scale in silico modelling (AesthetiSIM™), we evaluated excipient substitution across six marke…
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Breaking the 4-hour rule: Multiscale computational modelling redefines post-injection restrictions for botulinum neurotoxin A.
This study used a validated, literature anchored multiscale modelling platform (AesthetiSIM) to investigate whether common post injection behaviours influence the early distribution of botulinum toxin A (BoNT A). A cohort of 10,000 paired d…
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Variant-aware computational assessment of neutralizing antibody binding robustness to botulinum toxin A.
Botulinum neurotoxin type A (BoNT/A) is a widely used biologic therapeutic, yet the influence of natural toxin sequence variation on the stability of neutralizing antibody binding remains poorly understood. In this study, we performed a com…
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A Multicenter, Randomized, Evaluator-Blinded Study to Examine the Safety and Effectiveness of Hyaluronic Acid Filler in the Correction of Infraorbital Hollows.
[BACKGROUND] Hyaluronic acid injections are increasingly administered for correction of infraorbital hollows (IOHs). [OBJECTIVES] The objective of this study was to examine the effectiveness (IOH correction) and safety of Restylane Eyeligh…
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Efficacy and Safety of a New Resilient Hyaluronic Acid Filler in the Correction of Moderate-to-Severe Dynamic Perioral Rhytides: A 52-Week Prospective, Multicenter, Controlled, Randomized, Evaluator-Blinded Study.
[BACKGROUND] The perioral region is highly mobile and subject to multifactorial changes during aging. Resilient Hyaluronic Acid Redensity (RHAR), an RHA filler, was developed with the aim of optimizing outcomes in dynamic facial areas. [OB…
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Creation and validation of a photonumeric scale for assessment of lip fullness.
[BACKGROUND] Validated, objective clinical scales are needed to assess aesthetic improvement of the lips after augmentation with dermal fillers. [OBJECTIVE] To develop a lip fullness rating scale and establish its reliability for grading s…
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The Second of Two One-Year, Multicenter, Open-Label, Repeat-Dose, Phase II Safety Studies of PrabotulinumtoxinA for the Treatment of Moderate to Severe Glabellar Lines in Adult Patients.
[BACKGROUND] PrabotulinumtoxinA is a 900-kDa botulinum toxin type A produced by Clostridium botulinum. [OBJECTIVES] The authors sought to investigate the safety of prabotulinumtoxinA for treatment of glabellar lines. [METHODS] This was a …
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DaxibotulinumtoxinA for Injection for the Treatment of Glabellar Lines: Results from Each of Two Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase 3 Studies (SAKURA 1 and SAKURA 2).
[BACKGROUND] DaxibotulinumtoxinA for Injection (DAXI) is a novel botulinum toxin type A formulation in clinical development. A phase 2 dose-ranging study identified an optimal dose and demonstrated efficacy with a median duration of 24 week…
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Polymethylmethacrylate Collagen Gel-Injectable Dermal Filler for Full Face Atrophic Acne Scar Correction.
[BACKGROUND/OBJECTIVES] This trial evaluated the effectiveness and safety of Bellafill for full-face acne scar treatment. [PATIENTS AND METHODS] In this open-label, nonrandomized, multicenter pilot study investigating the use of polymethyl…
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Histoacryl. Its use in aesthetic facial plastic surgery.
Since their discovery in 1949, cyanoacrylates have evoked interest as being a possible ideal "tissue glue." Several different forms of these compounds have been developed in order to try to reduce or eliminate tissue toxicity. Butyl-2-cyano…