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The influence of obesity on folate status, DNA methylation and cancer-related gene expression in normal breast tissues from premenopausal women.
Epidemiological studies have established obesity as a critical risk factor for postmenopausal breast cancer (post-BC), whereas a reverse association holds prior to menopause. A significant scientific gap exists in understanding the mechanis…
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Secondary Upper Blepharoplasty: Converting Static Folds Into Dynamic Folds.
[BACKGROUND] For the patients seeking secondary upper blepharoplasty, a static double-eyelid fold featuring an immobile lower flap and depression of the fold is common. [OBJECTIVES] In this study, the authors propose a novel technique of r…
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Volume Retention After Facial Fat Grafting and Relevant Factors: A Systematic Review and Meta-analysis.
[BACKGROUND] Autologous fat grafting is common in facial reconstructive and cosmetic surgeries; the most important drawbacks are the high absorption rate and unpredictable volume retention rate. Surgeons usually make clinical judgements bas…
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A Novel JAK1 Mutant Breast Implant-Associated Anaplastic Large Cell Lymphoma Patient-Derived Xenograft Fostering Pre-Clinical Discoveries.
Breast implant-associated lymphoma (BIA-ALCL) has recently been recognized as an independent peripheral T-cell lymphoma (PTCL) entity. In this study, we generated the first BIA-ALCL patient-derived tumor xenograft (PDTX) model (IL89) and a …
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Extensive Microsurgical Reconstruction of Chest Wall Defects for Locally Advanced Breast Cancer: A 10-Year Single-Unit Experience.
[BACKGROUND] Despite improvements in the early detection of breast cancer, locally advanced breast cancer (LABC) involving the chest wall exists in developing countries. Surgical resection remains a controversial management option. This stu…
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Perioperative Risk Factors for Radial Forearm-Free Flap Complications.
[PURPOSE] To determine perioperative risk factors predicted complications in elderly Chinese patients undergoing oral and maxillofacial reconstruction with radial forearm free flaps (RFFF). [PATIENTS AND METHODS] The authors implemented a …
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[Surgical key points of precision functional sphincter-preserving surgery].
The principle of sphincter-preserving surgery is to preserve the anal sphincter function under the premise of radical resection. Due to low position of rectal tumor, conventional laparoscopic surgery has difficulties in operating in the dee…
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Elastic thread modified minimal access cranial suspension lift for lower and middle third facial rejuvenation.
Thread lift boasts the advantage of minimal invasion for facial rejuvenation and has been increasingly used nowadays. The purpose of this study was to evaluate the outcomes and safety of elastic thread when it was used in the modified minim…
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Rac3, but not Rac1, promotes ox-LDL induced endothelial dysfunction by downregulating autophagy.
The endothelial dysfunction induced by oxidized low-density lipoprotein (ox-LDL) plays an important role in the pathogenesis of atherosclerosis, which can lead to oxidative stress and inflammation. The role of autophagy in the process of at…
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Refinements of the application of paramedian forehead flap in nasal defects repair in Asian patients.
[BACKGROUND] Due to the relatively higher tendency of postsurgery scars, insufficient cartilage support, and low surgical acceptability, nasal defect repair with forehead flap in Asian patients needs further study. [OBJECTIVE] We aim to de…
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Management of gestational gigantomastia with breast reconstruction after mastectomy: case report and literature review.
Gestational gigantomastia (GGM) is a rare complication of pregnancy. The etiology of GGM is yet to be fully established. Treatment methods for GGM include medical therapy and surgery. If medical treatment is unsuccessful, surgery may be req…
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To use indwelling drainage or not in dual-plane breast augmentation mammoplasty patients: A comparative study.
To explore the necessity of indwelling drainage in dual-plane breast augmentation mammoplasty patients.Female patients (123 in total) were selected from June 2015 to June 2018 in the Department of Plastic Surgery at Peking Union Medical Col…
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Transbrow Excision Blepharoplasty for Upper Eyelid Dermatochalasis: A Modified Approach.
[BACKGROUNDS] Many aging women with upper lid dermatochalasis pluck their lower lateral eyebrows to combat lateral drooping. The authors present and evaluate outcomes of a modified excision blepharoplasty method performed using a transbrow …
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Inhibition of Rac1-dependent forgetting alleviates memory deficits in animal models of Alzheimer's disease.
Accelerated forgetting has been identified as a feature of Alzheimer's disease (AD), but the therapeutic efficacy of the manipulation of biological mechanisms of forgetting has not been assessed in AD animal models. Ras-related C3 botulinum…
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Negative pressure wound therapy for surgical wounds healing by primary closure.
[BACKGROUND] Indications for the use of negative pressure wound therapy (NPWT) are broad and include prophylaxis for surgical site infections (SSIs). While existing evidence for the effectiveness of NPWT remains uncertain, new trials necess…
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A new technique of revision septoplasty using semi-penetrating straight and circular incisions of the nasal septum.
[OBJECTIVE] This study aimed to investigate endoscopic revision septoplasty with semi-penetrating straight and circular incisions in patients for whom septoplasty was unsuccessful. [METHOD] Patients in this study (n = 14) had a deviation o…
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Dock2 in the development of inflammation and cancer.
An atypical guanine exchange factor, Dock2 is specifically expressed in hematopoietic cells and regulates activation and migration of immune cells through activating Ras-related C3 botulinum toxin substrate (Rac). Dock2 was shown to be crit…
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The Role of Negative Pressure Wound Therapy in Managing Chinese Patients With Wound-derived Acute Severe Illness.
[INTRODUCTION] Resulting mostly from major injury or infection, severe acute wounds are often accompanied by septic shock or multiple organ failure and associated with high disability and mortality rates. In managing Chinese patients with w…
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Emerging roles of RAC1 in treating lung cancer patients.
The Ras-related C3 botulinum toxin substrate 1 (RAC1), a member of the Rho family of small guanosine triphosphatases, is critical for many cellular activities, such as phagocytosis, adhesion, migration, motility, cell proliferation, and axo…
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Initial psychometric validation of the questionnaire on pain caused by spasticity (QPS).
[BACKGROUND] The Questionnaire on Pain caused by Spasticity (QPS) is a modular patient- and observer-reported outcome measure of spasticity-related pain (SRP) in children with cerebral palsy (CP). Originally developed for an English-speakin…
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The influence of tumor necrosis factor-α on the tumorigenic Wnt-signaling pathway in human mammary tissue from obese women.
Epidemiological studies have convincingly suggested that obesity is an important risk factor for postmenopausal breast cancer, but the mechanisms responsible for this relationship are still not fully understood. We hypothesize that obesity …
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[ESTABLISHMENT AND TESTING OF RATING SCALE OF RAT ROTATOR CUFF FUNCTION].
[OBJECTIVE] To provides an objective tool to evaluate rotator cuff function in rats. [METHODS] Sixty adult male Sprague Dawley rats, weighing (281.21 ± 20.12) g, were involved in this experiment. Botulinum toxin A (6 U/kg) was injected int…
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Rac1 overexpression is correlated with epithelial mesenchymal transition and predicts poor prognosis in non-small cell lung cancer.
Ras-related C3 botulinum toxin substrate1(Rac1) and epithelial mesenchymal transition (EMT) are key therapeutic targets in cancer. We investigated the clinical significance of Rac1 and markers of EMT expression in non-small cell lung cancer…
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Genetic variation in one-carbon metabolism in relation to genome-wide DNA methylation in breast tissue from heathy women.
Single nucleotide polymorphisms (SNPs) in one-carbon metabolism genes and lifestyle factors (alcohol drinking and breast folate) may be determinants of whole-genome methylation in the breast. DNA methylation profiling was performed using th…
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A Modified Method of Proximal Segment Alignment After Sagittal Split Ramus Osteotomy for Patients With Mandibular Asymmetry.
[PURPOSE] The purpose of this study was to evaluate a modified method of aligning the proximal segment after bilateral sagittal split ramus osteotomy (BSSO) in the treatment of patients with facial asymmetry. [PATIENTS AND METHODS] Eleven …
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Relationships among folate, alcohol consumption, gene variants in one-carbon metabolism and p16INK4a methylation and expression in healthy breast tissues.
p16(INK4a) is a tumor suppressor gene, frequently hypermethylated in breast cancer; this epigenetic silencing of p16(INK4a) occurs early in carcinogenesis. The risk factors and functional consequences of p16(INK4a) methylation are unknown. …
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Associations between genetic variation in one-carbon metabolism and LINE-1 DNA methylation in histologically normal breast tissues.
Genome-wide DNA hypomethylation is an early event in the carcinogenic process. Percent methylation of long interspersed nucleotide element-1 (LINE-1) is a biomarker of genome-wide methylation and is a potential biomarker for breast cancer. …
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TRIM24 links glucose metabolism with transformation of human mammary epithelial cells.
Tripartite motif 24 protein (TRIM24) is a plant homeodomain/bromodomain histone reader, recently associated with poor overall survival of breast-cancer patients. At a molecular level, TRIM24 is a negative regulator of p53 levels and a co-ac…
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[EFFECTIVENESS OF MODIFIED Park METHOD OF BLEPHAROPLASTY FOR CORRECTION OF MILD BLEPHAROPTOSIS].
[OBJECTIVE] To explore the effectiveness of the modified Park method of blepharoplasty for correction of mild blepharoptosis. [METHODS] Between October 2012 and January 2015, a new modified Park method of blepharoplasty was performed on 23…
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[Immediate breast and nipple reconstruction with the latissimus dorsi myocutaneous flap].
[OBJECTIVE] To investigate the feasibility of immediate breast and nipple-areola reconstruction after skin-sparing mastectomy. [METHODS] 24 patients who received skin-sparing mastectomy underwent immediate breast reconstruction with or wit…