논문 목록
2건 · 최신순-
Catch and Anchor Approach To Combat Both Toxicity and Longevity of Botulinum Toxin A.
Botulinum neurotoxins have remarkable persistence (∼weeks to months in cells), outlasting the small-molecule inhibitors designed to target them. To address this disconnect, inhibitors bearing two pharmacophores-a zinc binding group and a Cy…
-
Strategies to Counteract Botulinum Neurotoxin A: Nature's Deadliest Biomolecule.
Botulinum neurotoxin serotype A (BoNT/A), marketed commercially as Botox, is the most toxic substance known to man with an estimated intravenous lethal dose (LD) of 1-2 ng/kg in humans. Despite its widespread use in cosmetic and medicinal a…