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Breast Implant Rupture Is Strongly Associated with Capsular Contracture: An Intrapatient Study.
[BACKGROUND] Capsular contracture is a common complication following breast augmentation and reconstruction with implants. Implant rupture is suspected to cause capsular contracture, but the evidence remains limited. [METHODS] This intrapa…
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Quantifying Silicone Leakage In Vivo: Validation of a Reproducible Histological Method for Breast Implant Surveillance.
[BACKGROUND] Silicone leakage from breast implants may contribute to fibrosis leading to capsular contracture, yet no standardized method exists to quantify silicone leakage reliably. [OBJECTIVES] To validate a histological method for quan…
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Breast implant microbiome profile correlates with foreign body response severity.
Biomedical implants significantly enhance quality of life for millions of individuals worldwide. However, maintaining long-term implant function remains challenging, and it is often due to a severe foreign body response, characterized by fi…
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Transcriptome of Capsular Contracture around Breast Implants Mimics Allograft Rejection: A Matched Case-Control Study.
[BACKGROUND] Capsular contracture is a frequent and severe complication following breast implant surgery. Although several theories on the pathophysiology exist, the exact molecular mechanisms remain unclear. This study aimed to identify th…