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153건 · 최신순-
[Application of a new super-micro flap in endoscopic tympanoplasty].
To introduce a new design of super-micro flap for endoscopic ear surgery, and to evaluate the application effect of super-micro flap in endoscopic tympanoplasty. Between January, 2023 and March, 2024, 58 patients（64 ears） with tympanosclero…
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A high clinically translatable strategy to anti-aging using hyaluronic acid and silk fibroin co-crosslinked hydrogels as dermal regenerative fillers.
An ideal dermal filler should integrate filling, repair, and anti-aging effects, with immediate tissue augmentation, slow degradation, and progressive stimulation of collagen regeneration. However, commonly used hyaluronic acid (HA) hydroge…
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Validation of the Asian Midface Volume Deficit Severity Scale.
[BACKGROUND] Anatomical differences in facial aging and aesthetic needs of Asian and Caucasian individuals have led to disparate clinical rejuvenation strategies using filler augmentation for midface volume deficits. Therefore, the Asian Mi…
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Outcomes following intradetrusor onabotulinumtoxinA in a national cohort of nursing home residents.
[OBJECTIVES] To determine predictors of treatment success and complications following intradetrusor onabotulinumtoxinA injections among a large cohort of nursing home (NH) residents, representing one of the most frail and vulnerable populat…
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RAC1 promotes the occurrence and development of tongue squamous cell carcinoma by regulating RAC1/PAK1/LIMK1 signaling pathway.
Tongue squamous cell carcinoma (TSCC) remains an unsolved medical problem due to its poor local recurrence rate and prognosis. The purpose of this study was to investigate the expression characteristics of RAC-related C3 botulinum toxin sub…
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Role of IL-16 in age-related skeletal muscle atrophy: an integrated study.
[BACKGROUND] In this study, we aim to explore the roles of IL-16 in sarcopenia based on older orthopedic patients and animal research. [METHODS] This clinical research in this study was an observational investigation and included all the o…
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Treatment of Neuropsychiatric Symptoms in Parkinson's Disease With Botulinum Toxin A: A 12 week Randomized, Double-Blind, Placebo-Controlled Trial.
ObjectiveThe study aimed to evaluate the impact of Botulinum toxin A (BoNT/A) on neuropsychiatric symptoms in Parkinson's disease (PD) patients.MethodsA total of 125 PD patients and an equal number of age- and gender-matched healthy control…
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Case Report: fNIRS-guided rehabilitation in refractory post-traumatic dysphagia.
[BACKGROUND] Dysphagia is a common complication of severe traumatic brain injury (sTBI) and may persist despite standard treatment. For refractory cases, there appear to be no more effective therapeutic options available. [CASE INFORMATION…
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A Randomized Controlled Trial of Botulinum Toxin Combined with Non-Cross-Linked Bovine Collagen for Improving Periorbital Wrinkles.
[BACKGROUND] This study examined the clinical efficacy of botulinum toxin type A (BTX-A) combined with non-cross-linked bovine collagen in improving periorbital wrinkles. [METHODS] Forty participants with periorbital wrinkles were recruite…
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A Randomized, Double-Blind, Placebo-Controlled, Multicentered Study to Evaluate the Efficacy and Safety of MEI005 in Reducing Submental Fat in Chinese Adults.
[BACKGROUND] Submental fat (SMF) is a common aesthetic concern traditionally treated with liposuction. Nonsurgical alternatives, like injectable deoxycholic acid, are gaining popularity. However, no related products have been clinically app…
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Skin-derived vascularized lymph node transfer combining with liposuction in stages for bilateral lower extremity lymphedema: a case report.
Bilateral lower extremity lymphedema (LEL) significantly impairs patients' quality of life. A 66-year-old female patient, who developed bilateral LEL following cervical cancer surgery (classified as International Society of Lymphology stage…
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Overuse of Preoperative Mammography in Breast Reduction Surgery: Identifying Low-Value Care.
[BACKGROUND] Preoperative mammography in patients under 40 undergoing nononcologic breast reduction surgery is not recommended by national guidelines, including the 2014 ASPS Choosing Wisely statement. This study evaluated national trends, …
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Bacterial Lipoteichoic Acid Induces Capsular Contracture by Activating Innate Immune Response.
[BACKGROUND] Capsular contracture is attributed to an exaggerated fibrosis response within the capsule and is partly associated with bacterial contamination in situ. However, the cellular mechanisms that initiate this response are unclear. …
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Application of tensor fascia lata perforator flap in head and neck reconstruction.
The aim of this study was to describe the authors' experience in head and neck reconstruction with the tensor fascia lata perforator flap (TFLPF). Between April 2009 and August 2020, 16 patients underwent head and neck reconstruction with a…
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Resurfacing of multiple adjacent defects with free multipaddle SCIAP flaps.
[BACKGROUND] The efficient resurfacing of multiple adjacent defects (MADs) requires precise reconstructive strategy. Various approaches (e.g., several flap transferring or prelamination of the recipient site) have been reported, but recipie…
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A separate-dural-incision method of extradural dumbbell spinal schwannoma resection: cumulative experience at a single center.
[OBJECTIVE] To present our experience in the surgical management of completely extradural dumbbell spinal schwannomas with a new surgical strategy. [METHOD] This study is a case series of patients treated at the Neurosurgery Department of …
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Evaluation of different methods of transoral minimally invasive surgery for supraglottic laryngeal carcinoma.
[BACKGROUND AND OBJECTIVES] To analyze oncological and functional results of transoral minimally invasive surgery (TMIS) for supraglottic laryngeal carcinoma (SGLC), and investigate independent prognostic factors. [METHODS] Seventy SGLC pa…
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All-Aqueous Soft Milli-swimmers.
Microscale swimmers are attractive for targeted drug delivery, noninvasive microsurgery and environmental remediation at different length scales, among which, Marangoni-based swimmers have garnered considerable attention due to their indepe…
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Short-Term Effects of Poly-L-Lactic Acid-b-Polyethylene Glycol Microsphere Injection on Different Adipose Tissue Types in Rats.
[BACKGROUND] Wrinkles and sagging, characteristics of aging, are associated with reductions in collagen and fat. Poly-L-lactic acid (PLLA) is widely used clinically as a tissue filler owing to its good biocompatibility and ability to improv…
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Exploring the Biomarkers and Potential Mechanisms of Botulinum Toxin Type A in the Treatment of Microglial Inflammatory Activation through P2X7 Receptors based on Transcriptome Sequencing.
[AIMS] This study aims to explore the potential mechanism by which Botulinum toxin type A (BoNT/ A) inhibits microglial inflammatory activation through P2X7 receptors (P2X7R). [BACKGROUND] BoNT/A is a promising analgesic drug, and previous…
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Nerve Distribution Method is Superior to the Conventional Method in BoNT-A Treatment of Trapezius Hypertrophy: A Randomized Controlled Trial.
The contour of the neck and shoulder is defined by the trapezius muscle (TM). Beyond facial procedures, botulinum toxin A (BoNT-A) injections has been increasingly adopted to create a smooth shoulder line. Several studies described the intr…
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Botulinum Toxin Type A Alleviates Androgenetic Alopecia by Inhibiting Apoptosis of Dermal Papilla Cells via Targeting circ_0135062/miR-506-3p/Bax Axis.
Botulinum toxin type A (BTXA) has the potential to treat androgenetic alopecia (AGA); however, its impact on the apoptosis of dermal papillary cells (DPCs) is not yet fully understood. Noncoding RNAs play a crucial role in AGA. In this stud…
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Dissecting and tracing the gut microbiota of infants with botulism: a cross sectional and longitudinal study.
[BACKGROUND] Infant botulism is caused by botulinum neurotoxin (BoNT), which is mainly produced by . However, there is a lack of longitudinal cohort studies on infant botulism. Herein, we have constructed a cross-sectional and longitudinal …
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S-Nitrosylation of Septin2 Exacerbates Aortic Aneurysm and Dissection by Coupling the TIAM1-RAC1 Axis in Macrophages.
[BACKGROUND] S-Nitrosylation (SNO), a prototypic redox-based posttranslational modification, is involved in cardiovascular disease. Aortic aneurysm and dissection are high-risk cardiovascular diseases without an effective cure. The aim of t…
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Deciphering Depressor Anguli Oris for Lower Face Rejuvenation: A Prospective Ultrasound-based Investigation.
[BACKGROUND] The depressor anguli oris muscle (DAO) is a pivotal treatment target when creating a harmonic jawline. However, evidence of its live morphology remains scarce. [OBJECTIVES] In this study we aimed to reevaluate the DAO with a f…
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Efficacy and safety of sequential treatment with botulinum toxin type A, fractional CO2 laser, and topical growth factor for hypertrophic scar management: a retrospective analysis.
Hypertrophic scars arise from aberrant wound healing and can lead to functional and aesthetic impairments. One of the common interventions for treating hypertrophic scars is fractional carbon dioxide (CO2) laser, which employs narrow laser …
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Three-dimensional analysis of hard and soft tissue changes in skeletal class II patients with high mandibular plane angle undergoing surgery.
This study aimed to study 3-dimensional (3D) changes of hard and soft tissues of skeletal class II patients after 2-jaw surgery and genioplasty. 32 adult patients diagnosed with mandibular hypoplasia who underwent 2-jaw surgery of maxillary…
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A 52-week follow-up, multi-center, randomized, double-blinded comparison of efficacy and safety of two hyaluronic acid fillers for the treatment of moderate-to-severe nasolabial folds in Chinese population.
[INTRODUCTION] To investigate the efficacy and safety of Cutegel MAX (Cutegel) in the correction of moderate-to-severe nasolabial folds (NLFS) compared to Restylane (Restylane, control). [METHODS] This study was a 52-week, multicenter, ran…
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Effects of Heated Infiltration Solutions and Forced-Air Heating Blankets on Intraoperative Hypothermia During Liposuction: A Factorial Randomized Controlled Trial.
[BACKGROUND] This study was conducted to compare the effects of heat preservation by two recommended methods, heated infiltration solutions and forced-air heating blankets, in patients undergoing liposuction under general anesthesia. [METH…
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Subanesthetic Dose of Esketamine Improves the Sedative and Analgesic Effects of Dexmedetomidine and Remifentanil in Liposuction Anesthesia: A Prospective, Double-Blinded, Randomized Controlled Trial.
[PURPOSE] Esketamine have anesthetic and analgesic properties. This study aimed to observe the enhancing effect of subanesthetic doses of esketamine (0.15-0.3 mg/kg/h) with dexmedetomidine and remifentanil during anesthesia for liposuction …