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43건-
Risk factors and development of a predictive nomogram model for acute postoperative pain in oral cancer.
This study aimed to determine the incidence and independent factors of acute postoperative pain in oral cancer patients and develop an individualized predictive nomogram. A retrospective cohort study included 458 oral cancer patients who un…
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Clinical application of the free anterolateral thigh chimeric muscle flap for reconstruction of composite tissue defects of the forearm and hand.
[BACKGROUND] Composite tissue defects (CTD) of the forearm and hand commonly result from industrial, agricultural, and traffic-related injuries and often involve multiple anatomical structures, making reconstruction challenging. Simple skin…
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Globus pallidus internus versus subthalamic nucleus deep brain stimulation for Meige syndrome: a retrospective study on short- and long-term efficacy.
[OBJECTIVE] Meige syndrome is a complex movement disorder characterized by blepharospasm and oromandibular dystonia that is often resistant to conventional pharmacological and botulinum toxin treatments. Deep brain stimulation (DBS) offers …
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Temporomandibular joint capsule suspension for neocondyle stability in free fibular flap reconstruction of the mandibular condyle.
[OBJECTIVES] This study evaluates the efficacy of a new temporomandibular joint (TMJ) capsule suspension technique for stabilizing the TMJ after free fibular flap reconstruction of the mandibular condyle. [PATIENTS AND METHODS] Patients un…
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Partial vs Whole Laryngeal Radiotherapy for Clinical Stage T1-2N0M0/Tis Laryngeal Carcinoma.
[IMPORTANCE] The current standard treatment for clinical tumor stage 1 to 2 or in situ laryngeal carcinoma without node involvement or metastases (T1-2N0M0/Tis) is whole laryngeal radiotherapy (WLRT), whereas microsurgery typically resects …
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Nonhuman Primate Model of Super-selective Intra-arterial Ophthalmic Arterial Interventional Thrombolysis for Treatment of Ophthalmic Arterial Embolism Resulting From Hyaluronic Acid Filler Cosmetic Injection.
[BACKGROUND] Although intravascular interventional thrombolysis therapy is beneficial for patients suffering from impaired vision caused by hyaluronic acid (HA) embolism, there is no medical evidence-base for the efficacy of this treatment.…
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Effects of different rehabilitation therapies on upper extremity motor function and activities of daily living in hemiplegic patients with stroke: A network meta-analysis.
[BACKGROUND] To compare the effects of different rehabilitation therapies on the scores of Fugl-Meyer assessment of motor recovery (FMA), the action research arm test (ARAT), and modified Barthel index in hemiplegic patients with stroke by …
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[Clinical analysis of denture rehabilitation after mandibular fibula free-flap reconstruction].
[OBJECTIVE] To evaluate the postoperative denture restoration and denture function in patients with mandibular defect reconstructed with vascularized free fibula flap. [METHODS] In the study, 154 patients who underwent mandibular segment r…
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Prognostic impact of sodium fluorescein-guided microsurgery on cognitive function, neuropeptide dynamics, and short-term outcomes in brain glioma patients.
This study conducted a retrospective analysis on 107 brain glioma patients treated from January 2018 to February 2020 to assess the impact of sodium fluorescein-guided microsurgery on postoperative cognitive function and short-term outcomes…
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The role of surgical navigation in computer-assisted mandibular reconstruction: is it necessary?
[BACKGROUND] Accurate mandibular reconstruction following tumor ablation is important yet challenging. While computer-assisted surgery and surgical navigation have been applied widely in maxillofacial reconstruction, the accuracy and the ef…
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Outcome Evaluation of Three-Dimensionally Printed Patient-Specific Surgical Plates for Mandibular Reconstruction.
[STUDY DESIGN] Prospective and retrospective studies. [OBJECTIVE] The aim of this study was to evaluate the clinical effects and accuracy of three-dimensionally (3D)-printed patient-specific surgical plates used for mandibular defect recon…
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Neuronal Membrane-Derived Nanodiscs for Broad-Spectrum Neurotoxin Detoxification.
Neurotoxins pose significant challenges in defense and healthcare due to their disruptive effects on nervous tissues. Their extreme potency and enormous structural diversity have hindered the development of effective antidotes. Motivated by…
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Neutralizing chimeric heavy-chain antibody targeting the L-HN domain of Clostridium botulinum neurotoxin type F.
Botulinum toxin (BoNT) from Clostridium botulinum is the most toxic biotoxin known and is also an important bioterrorism agent. After poisoning, the only effective treatment is injection of antitoxin. However, neutralizing nanoantibodies ar…
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Design and evaluation of mRNA encoding recombinant neutralizing antibodies for botulinum neurotoxin type B intoxication prophylaxis.
Among all natural and synthetic toxins, botulinum neurotoxins (BoNTs), produced by in an anaerobic environment, are the most toxic polymer proteins. Currently, the most effective modalities for botulism prevention and treatment are vaccina…
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Evaluation of safety, efficacy, and risk factors of different breast reconstruction strategies following polyacrylamide hydrogel removal: A 20-year retrospective cohort study of 436 cases.
[BACKGROUND] Globally implemented for breast augmentation, polyacrylamide hydrogel (PAAG) always leads to breast deformity upon its removal. Despite a pressing need for breast reconstruction following PAAG removal to address aesthetic issue…
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Case report: Iatrogenic tattoos caused by skin marking pen in a postoperative patient.
In this report, a female patient suffering from pigment retention caused by a skin marking pen was elucidated. The patient underwent blepharoplasty 6 months ago and presented with blue-black linear marks at the upper eyelid incision 2 weeks…
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Modified individualized titanium mesh in orbital floor reconstruction for preventing exposure.
[OBJECTIVE] To describe a novel method of medial fixation of titanium mesh with a right-angled screwdriver for orbital floor and maxillary reconstruction and to compare the reconstruction outcome of orbital floor reconstruction with modifie…
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Biomechanical behavior of the three-dimensionally printed surgical plates for mandibular defect reconstruction: a finite element analysis.
The aim of the study was to investigate the biomechanical behavior of three-dimensionally (3D)-printed surgical plates used for mandibular defect reconstruction, compare them with conventional surgical plates, and provide experimental evide…
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Intraarterial Thrombolytic Treatment for Visual Deficits Caused by Hyaluronic Acid Filler: Efficacy, Safety, and Prognostic Factors.
[BACKGROUND] The benefits of intraarterial thrombolytic treatment (IATT) in reversing hyaluronic acid (HA)-related visual deficits remain unclear. This study aimed to report a 5-year experience in the treatment of visual deficits resulting …
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Botulinum Toxins for the Treatment of Raynaud Phenomenon: A Systematic Review With Meta-analysis.
[OBJECTIVE] Botulinum toxin (Btx) therapy has emerged as a potential treatment for patients with Raynaud phenomenon (RP) in recent years. This study aimed to investigate the efficacy and safety of Btx treatment for RP. [METHODS] Databases …
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[Clinical analysis of selective tracheostomy necessary for patients undergoing head and neck surgery with free flap reconstruction].
[OBJECTIVE] To discover the factors that may affect the use of selective tracheostomy among patients who have undergone head and neck surgeries with free flap reconstruction, so that the patients will not need tracheostomy nor receive the u…
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Dynamically monitoring lymphatic and vascular systems in physiological and pathological conditions of a swine model via a portable NIR-II imaging system with ICG.
NIR-II imaging with indocyanine green (ICG) has been clinically used in liver tumor resection. However, few data are available concerning the application of ICG-NIR-II in lymphatic and vascular systems in clinic. To expand the application a…
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First clinical applications for the NIR-II imaging with ICG in microsurgery.
In microsurgery, it is always difficult to accurately identify the blood supply with ease, such as vascular anastomosis, digit replantation, skin avulsion reconstruction and flap transplantation. Near-infrared window I (NIR-I, 700-900 nm) i…
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Hengli Chinese Botulinum Toxin Type A for Treatment of Patients With Overactive Bladder: A Multicenter, Prospective, Randomized, Double-Blind, Placebo-Controlled Trial.
To evaluate the efficacy and safety of Hengli Chinese botulinum toxin type A (BTX-A; 100 U) in Chinese patients with overactive bladder. This study was a multicenter, randomized, double-blind, placebo-controlled trial in Chinese patients w…
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Synthesis and activity evaluation of selenazole-coupled CPI-1 irreversible bifunctional inhibitors for botulinum toxin A light chain.
A series of novel conjugates of benzoselenazole or selenazole and CPI-1 were designed, synthesized, and evaluated for inhibitory activities against the botulinum neurotoxin A (BoNT/A) light chain (LC) and BoNT/A in vivo. The results show th…
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Rapid and sensitive detection of botulinum toxin type A in complex sample matrices by AlphaLISA.
Botulinum toxin A(BoNT/A) is a neurotoxin produced by the bacteria , which can cause serious food poisoning and is recognized as a potential biological warfare agent. BoNT/A is does not degrade easily and can remain in the complex matrix fo…
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Long-term Effect of Individualized Titanium Mesh in Orbital Floor Reconstruction After Maxillectomy.
[OBJECTIVE] The aim of this study was to determine the clinical outcomes and long-term stability of individualized titanium mesh combined with free flap for orbital floor reconstruction after maxillectomy and to identify the risk factors fo…
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Three-dimensional morphological analysis of neocondyle bone growth after fibula free flap reconstruction.
The aim of this retrospective study was to verify the three-dimensional morphological change in neocondyle bone growth after fibula free flap (FFF) reconstruction. The independent variables were age, sex, and diagnosis. Outcome variables in…
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Percutaneous Full-Endoscopic C2 Ganglionectomy for the Treatment of Intractable Occipital Neuralgia: Technical Note.
[BACKGROUND] The C-2 dorsal root ganglionectomy procedure can provide effective treatment for intractable occipital neuralgia (ON). However, the traditional microsurgery of C2 ganglionectomy needs a wide incision and significant paraspinous…
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Efficacy of intra-arterial thrombolytic therapy for vision loss resulting from hyaluronic acid filler embolization.
[BACKGROUND] The incidence of hyaluronic acid (HA) embolism has increased markedly in recent years. HA embolism can lead to serious complications such as blindness, eye and eyelid movement disorders, skin necrosis, and cerebral embolism. Ho…