Follow-up study of the first genome-wide association scan in alopecia areata: IL13 and KIAA0350 as susceptibility loci supported with genome-wide significance.
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📑 인용한 논문 (6) ▾
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연도별 인용 (2012–2026) · 합계 132
OpenAlex 토픽 ·
Hair Growth and Disorders
Dermatology and Skin Diseases
IL-33, ST2, and ILC Pathways
Recently, the first genome-wide association study (GWAS) of alopecia areata (AA) was conducted in a North-American sample, and this identified eight susceptibility loci surpassing genome-wide signific
- OR 1.28
- 연구 설계 meta-analysis
APA
Dagny Jagielska, Silke Redler, et al. (2012). Follow-up study of the first genome-wide association scan in alopecia areata: IL13 and KIAA0350 as susceptibility loci supported with genome-wide significance.. The Journal of investigative dermatology, 132(9), 2192-7. https://doi.org/10.1038/jid.2012.129
MLA
Dagny Jagielska, et al.. "Follow-up study of the first genome-wide association scan in alopecia areata: IL13 and KIAA0350 as susceptibility loci supported with genome-wide significance.." The Journal of investigative dermatology, vol. 132, no. 9, 2012, pp. 2192-7.
PMID
22534877 ↗
Abstract 한글 요약
Recently, the first genome-wide association study (GWAS) of alopecia areata (AA) was conducted in a North-American sample, and this identified eight susceptibility loci surpassing genome-wide significance. The aim of the present follow-up association analysis was to confirm five of these eight loci (single-nucleotide polymorphisms (SNPs) from the CTLA4, IL-2RA, and HLA regions were not included due to previous own findings) and test 12 other loci from the GWAS, which did not surpass the threshold for genome-wide significance. Twenty-three SNPs from the 17 loci were investigated using a sample of 1,702 Central European AA patients and 1,723 controls. Of the five loci with previously reported genome-wide significance, association was confirmed for all of these: ULBP3/ULBP6, PRDX5, IL-2/IL-21, STX17, and IKZF4/ERBB3 (P-value <0.05). To detect robust evidence for association among the 12 other loci, a meta-analysis of the present association data and the data of the recent GWAS was performed. Genome-wide significant association was found for rs20541 (P(comb)=7.52 × 10(-10); odds ratio (OR)=1.30 (1.23-1.38)) and rs998592 (P(comb)=1.11 × 10(-11); OR=1.28 (1.21-1.36)), thus establishing IL-13 and KIAA0350/CLEC16A as susceptibility loci for AA. Interestingly, IL-13 and KIAA0350/CLEC16A are susceptibility loci for other autoimmune diseases, supporting the hypothesis of shared pathways of autoimmune susceptibility.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Adolescent
- Adult
- Aged
- 80 and over
- Alopecia Areata
- Autoimmune Diseases
- Child
- Preschool
- Female
- Follow-Up Studies
- Genetic Loci
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Interleukin-13
- Lectins
- C-Type
- Middle Aged
- Monosaccharide Transport Proteins
- Polymorphism
- Single Nucleotide
- Young Adult
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