Alopecia Areata: an Update on Etiopathogenesis, Diagnosis, and Management.
5/5 보강
TL;DR
The recent advances in the pathogenesis, diagnosis, and treatment of AA are discussed, including antihistamines, platelet-rich plasma (PRP) injection, and other novel therapies have been well explored.
📑 코퍼스 인용 관계
· 인용됨 141 · 인용함 175
→ 이 논문이 인용한 논문 (6) ▾
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연도별 인용 (2021–2026) · 합계 349
OpenAlex 토픽 ·
Hair Growth and Disorders
Autoimmune Bullous Skin Diseases
Dermatologic Treatments and Research
🇰🇷 한글 요약 🌐 Abstract
【연구 목적】
원형 탈모증(Alopecia Areata, AA)의 병태생리, 진단, 치료에 대한 최신 지견을 정리하여 임상 적용 방안을 제시하는 종설 논문입니다.
【방법】
AA의 병인, 임상양상, 기존 및 신규 치료법에 관한 최근 연구들을 종합 검토한 문헌 고찰(review)입니다.
【주요 결과】
AA는 전 인구의 약 2%가 이환되는 만성 자가면역질환으로, 모낭(hair follicle)의 면역특권(immune privilege) 붕괴가 핵심 기전이며 유전·환경 인자가 복합적으로 작용합니다. 기존 치료(스테로이드, 면역조절제, 미녹시딜, 접촉면역요법)는 효과가 제한적이고 재발률·부작용이 높으며, 최근에는 JAK 억제제, 생물학적 제제, 항히스타민제, 자가혈청 혈소판풍부혈장(PRP) 주사 등 새로운 치료 전략이 부상하고 있습니다.
【임상적 시사점 (성형외과 의사 관점)】
모발이식 상담 시 활동성 AA 환자는 자가면역 특성상 이식 모낭도 공격받을 수 있어 최소 1~2년 안정기 확인 후 신중히 결정해야 합니다. 두피(scalp) 부분 탈모 환자에게는 PRP 주사를 보조요법으로 도입할 수 있고, 중증·재발성 환자는 JAK 억제제 처방 가능한 피부과로 협진 의뢰하는 것이 바람직합니다.
Alopecia areata (AA) is a common chronic tissue-specific autoimmune disease, resulting in hair loss, that affects up to 2% of the general population. The exact pathobiology of AA has still remained elusive, while the common theory is the collapse of the immune privilege of the hair follicle caused by immunological mechanism. Multiple genetic and environment factors contribute to the pathogenesis of AA. There are several clinical treatments for AA, varying from one or multiple well-defined patches to more diffuse or total hair loss of the scalp (alopecia totalis) or hair loss of the entire body (alopecia universalis). The available treatments for AA, such as corticosteroids and other immunomodulators, minoxidil, and contact immunotherapy, are of limited efficacy with a high risk of adverse effects and high recurrence rates, especially for patients with severe AA. Recent insights into the pathogenesis of AA have led to the development of new treatment strategies, such as Janus kinase (JAK) inhibitors, biologics, and several small molecular agents. In addition, modern therapies for AA, including antihistamines, platelet-rich plasma (PRP) injection, and other novel therapies have been well explored. In this review, we discussed the recent advances in the pathogenesis, diagnosis, and treatment of AA.
【연구 목적】 원형 탈모증(Alopecia Areata, AA)의 병태생리, 진단, 치료에 대한 최신 지견을 정리하여 임상 적용 방안을 제시하는 종설 논문입니다.
APA 7
Zhou, C., Li, X., Wang, C., & Zhang, J. (2021). Alopecia areata: An update on etiopathogenesis, diagnosis, and management.. Clinical reviews in allergy & immunology, 61(3), 403-423. https://doi.org/10.1007/s12016-021-08883-0
Vancouver
Zhou C, Li X, Wang C, Zhang J. Alopecia Areata: an Update on Etiopathogenesis, Diagnosis, and Management. Clin. revi. alle. & immu.. 2021;61(3):403-423. doi:10.1007/s12016-021-08883-0
AMA 11
Zhou C, Li X, Wang C, Zhang J. Alopecia Areata: an Update on Etiopathogenesis, Diagnosis, and Management. Clin. revi. alle. & immu.. 2021;61(3):403-423. doi:10.1007/s12016-021-08883-0
Chicago
Zhou, C., Li, X., Wang, C., and Zhang, J.. 2021. "Alopecia Areata: an Update on Etiopathogenesis, Diagnosis, and Management." Clinical reviews in allergy & immunology 61 (3): 403-423. https://doi.org/10.1007/s12016-021-08883-0
MLA 9
Zhou, C., et al. "Alopecia Areata: an Update on Etiopathogenesis, Diagnosis, and Management." Clinical reviews in allergy & immunology, vol. 61, no. 3, 2021, pp. 403-423. doi:10.1007/s12016-021-08883-0.
PMID
34403083 ↗
추출된 의학 개체 (NER)
전체 NER 표 보기
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 질환 | alopecia areata
|
원형 탈모증 | dict | 2 | |
| 해부 | hair follicle
|
모낭 | dict | 1 | |
| 해부 | scalp
|
두피 | dict | 1 | |
| 약물 | minoxidil
|
미녹시딜 | dict | 1 |
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
인용 관계
그래프 OA 노드: 11/16 (69%)
· 참조 5편 · 후속 6편
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