Alopecia areata: A multifactorial autoimmune condition.
5/5 보강
TL;DR
Various genetic and environmental factors that cause autoimmunity are discussed and the immune mechanisms that lead to hair loss in alopecia areata patients are described.
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📑 인용한 논문 (6) ▾
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연도별 인용 (2019–2026) · 합계 295
OpenAlex 토픽 ·
Hair Growth and Disorders
RNA regulation and disease
Dermatology and Skin Diseases
🇰🇷 한글 요약 🌐 Abstract
【연구 목적】
원형 탈모증(Alopecia areata, AA)의 병인과 병태생리를 종합적으로 검토하여, 자가면역을 유발하는 유전적·환경적 요인과 모낭(hair follicle) 손상에 관여하는 면역학적 기전을 정리하는 것을 목적으로 한 종설(review) 논문이다.
【방법】
원형 탈모증과 관련된 기존 문헌을 검토하여 자가면역 발생에 기여하는 다양한 유전적·환경적 인자와, 모낭 주위 림프구 침윤 및 항체 매개 면역 반응을 중심으로 한 발모 손실 기전을 고찰하였다.
【주요 결과】
원형 탈모증은 모낭 주위 림프구 침윤과 IFN-γ에 의한 비흉터성(non-scarring) 탈모를 일으키며, 모낭 세포에 대한 IgG 항체도 검출된다. 두피(scalp)의 작은 원형 탈모반에서 시작해 전두 탈모(Alopecia totalis) 또는 전신 탈모(Alopecia universalis)로 진행할 수 있고, 다른 자가면역질환과 동반되거나 감염·염증에 속발하여 발생할 수 있다.
【임상적 시사점 (성형외과 의사 관점)】
원형 탈모증은 모낭이 보존되는 자가면역 질환이므로 모발이식(hair transplantation)의 일차 적응증이 아니며, 활동성 병변에서 이식 시 코베너(Koebner) 현상으로 재탈모가 유발될 수 있어 충분한 안정기 확보가 필수적이다. 빠른 탈모 진행과 외형 변화로 환자의 심리적·정신과적 합병증 위험이 높으므로 상담 시 정서적 지지와 피부과적 면역치료(국소·전신 스테로이드, JAK 억제제 등) 우선 의뢰를 고려하고, 다른 자가면역질환 동반 여부를 반드시 문진해야 한다.
Alopecia areata is an autoimmune disease that results in non-scarring hair loss, and it is clinically characterised by small patches of baldness on the scalp and/or around the body. It can later progress to total loss of scalp hair (Alopecia totalis) and/or total loss of all body hair (Alopecia universalis). The rapid rate of hair loss and disfiguration caused by the condition causes anxiety on patients and increases the risks of developing psychological and psychiatric complications. Hair loss in alopecia areata is caused by lymphocytic infiltrations around the hair follicles and IFN-γ. IgG antibodies against the hair follicle cells are also found in alopecia areata sufferers. In addition, the disease coexists with other autoimmune disorders and can come secondary to infections or inflammation. However, despite the growing knowledge about alopecia areata, the aetiology and pathophysiology of disease are not well defined. In this review we discuss various genetic and environmental factors that cause autoimmunity and describe the immune mechanisms that lead to hair loss in alopecia areata patients.
【연구 목적】 원형 탈모증(Alopecia areata, AA)의 병인과 병태생리를 종합적으로 검토하여, 자가면역을 유발하는 유전적·환경적 요인과 모낭(hair follicle) 손상에 관여하는 면역학적 기전을 정리하는 것을 목적으로 한 종설(review) 논문이다.
APA 7
Simakou, T., Butcher, J. P., Reid, S., & Henriquez, F. L. (2019). Alopecia areata: A multifactorial autoimmune condition.. Journal of autoimmunity, 98, 74-85. https://doi.org/10.1016/j.jaut.2018.12.001
Vancouver
Simakou T, Butcher JP, Reid S, Henriquez FL. Alopecia areata: A multifactorial autoimmune condition. Journal of autoimmunity. 2019;98:74-85. doi:10.1016/j.jaut.2018.12.001
AMA 11
Simakou T, Butcher JP, Reid S, Henriquez FL. Alopecia areata: A multifactorial autoimmune condition. Journal of autoimmunity. 2019;98:74-85. doi:10.1016/j.jaut.2018.12.001
Chicago
Simakou, T., Butcher, J. P., Reid, S., and Henriquez, F. L.. 2019. "Alopecia areata: A multifactorial autoimmune condition." Journal of autoimmunity 98: 74-85. https://doi.org/10.1016/j.jaut.2018.12.001
MLA 9
Simakou, T., et al. "Alopecia areata: A multifactorial autoimmune condition." Journal of autoimmunity, vol. 98, 2019, pp. 74-85. doi:10.1016/j.jaut.2018.12.001.
PMID
30558963 ↗
추출된 의학 개체 (NER)
전체 NER 표 보기
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 질환 | alopecia areata
|
원형 탈모증 | dict | 6 | |
| 해부 | scalp
|
두피 | dict | 2 | |
| 해부 | hair follicle
|
모낭 | dict | 1 |
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Adrenal Cortex Hormones
- Alopecia
- Alopecia Areata
- Animals
- Autoimmunity
- Cell Movement
- Gene-Environment Interaction
- Hair Follicle
- Humans
- Immunoglobulin G
- Insect Proteins
- Lectins
- C-Type
- Lymphocyte Activation
- Lymphocytes
- Mice
- Scalp
- Alopecia areata
- Autoreactive lymphocytes
- Infection
- JAK inhibitors
- Oxidative stress
- Polygenic autoimmune disease
인용 관계
그래프 OA 노드: 6/8 (75%)
· 참조 0편 · 후속 6편
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