Alopecia areata: a review of disease pathogenesis.
4/5 보강
TL;DR
Alopecia areata is a disorder that results in nonscarring hair loss, and the psychological impact can be significant, leading to feelings of depression and social isolation.
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· 인용됨 93
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연도별 인용 (2018–2026) · 합계 279
OpenAlex 토픽 ·
Hair Growth and Disorders
Immune Cell Function and Interaction
Dermatology and Skin Diseases
Abstract 🌐 Abstract
[BACKGROUND] Alopecia areata is a disorder that results in nonscarring hair loss. The psychological impact can be significant, leading to feelings of depression and social isolation. Objectives In this article, we seek to review the pathophysiological mechanisms proposed in recent years in a narrative fashion.
[METHODS] We searched MEDLINE and Scopus for articles related to alopecia areata, with a particular emphasis on its pathogenesis.
[RESULTS] The main theory of alopecia areata pathogenesis is that it is an autoimmune phenomenon resulting from a disruption in hair follicle immune privilege. What causes this breakdown is an issue of debate. Some believe that a stressed hair follicle environment triggers antigen presentation, while others blame a dysregulation in the central immune system entangling the follicles. Evidence for the latter theory is provided by animal studies, as well investigations around the AIRE gene. Different immune-cell lines including plasmacytoid dendritic cells, natural killer cells and T cells, along with key molecules such as interferon-γ, interleukin-15, MICA and NKG2D, have been identified as contributing to the autoimmune process.
[CONCLUSIONS] Alopecia areata remains incurable, although it has been studied for years. Available treatment options at best are beneficial for milder cases, and the rate of relapse is high. Understanding the exact mechanisms of hair loss in alopecia areata is therefore of utmost importance to help identify potential therapeutic targets.
[METHODS] We searched MEDLINE and Scopus for articles related to alopecia areata, with a particular emphasis on its pathogenesis.
[RESULTS] The main theory of alopecia areata pathogenesis is that it is an autoimmune phenomenon resulting from a disruption in hair follicle immune privilege. What causes this breakdown is an issue of debate. Some believe that a stressed hair follicle environment triggers antigen presentation, while others blame a dysregulation in the central immune system entangling the follicles. Evidence for the latter theory is provided by animal studies, as well investigations around the AIRE gene. Different immune-cell lines including plasmacytoid dendritic cells, natural killer cells and T cells, along with key molecules such as interferon-γ, interleukin-15, MICA and NKG2D, have been identified as contributing to the autoimmune process.
[CONCLUSIONS] Alopecia areata remains incurable, although it has been studied for years. Available treatment options at best are beneficial for milder cases, and the rate of relapse is high. Understanding the exact mechanisms of hair loss in alopecia areata is therefore of utmost importance to help identify potential therapeutic targets.
Alopecia areata is a disorder that results in nonscarring hair loss, and the psychological impact can be significant, leading to feelings of depression and social isolation.
APA 7
Rajabi, F., Drake, L. A., Senna, M. M., & Rezaei, N. (2018). Alopecia areata: A review of disease pathogenesis.. The British journal of dermatology, 179(5), 1033-1048. https://doi.org/10.1111/bjd.16808
Vancouver
Rajabi F, Drake LA, Senna MM, Rezaei N. Alopecia areata: a review of disease pathogenesis. Brit. jour. derm.. 2018;179(5):1033-1048. doi:10.1111/bjd.16808
AMA 11
Rajabi F, Drake LA, Senna MM, Rezaei N. Alopecia areata: a review of disease pathogenesis. Brit. jour. derm.. 2018;179(5):1033-1048. doi:10.1111/bjd.16808
Chicago
Rajabi, F., Drake, L. A., Senna, M. M., and Rezaei, N.. 2018. "Alopecia areata: a review of disease pathogenesis." The British journal of dermatology 179 (5): 1033-1048. https://doi.org/10.1111/bjd.16808
MLA 9
Rajabi, F., et al. "Alopecia areata: a review of disease pathogenesis." The British journal of dermatology, vol. 179, no. 5, 2018, pp. 1033-1048. doi:10.1111/bjd.16808.
PMID
29791718 ↗
추출된 의학 개체 (NER)
전체 NER 표 보기
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 질환 | alopecia areata
|
원형 탈모증 | dict | 6 | |
| 질환 | alopecia areata
|
원형 탈모증 | dict | 6 | |
| 해부 | hair follicle
|
모낭 | dict | 2 | |
| 해부 | hair follicle
|
모낭 | dict | 2 | |
| 해부 | hair follicle
|
모낭 | dict | 2 |
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Alopecia Areata
- Animals
- Autoimmune Diseases
- Dendritic Cells
- Disease Models
- Animal
- Hair Follicle
- Histocompatibility Antigens Class I
- Humans
- Immune Privilege
- Immunologic Factors
- Interferon-gamma
- Interleukin-15
- Keratinocytes
- Killer Cells
- Natural
- NK Cell Lectin-Like Receptor Subfamily K
- Recurrence
- T-Lymphocytes
- Transcription Factors
- Treatment Outcome
- AIRE Protein
인용 관계
그래프 OA 노드: 6/8 (75%)
· 참조 0편 · 후속 6편
이 논문을 인용한 후속 연구 20
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- Psychological Profile and Quality of Life of Patients with Alopecia Areata.
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- Comorbidities in Androgenetic Alopecia: A Comprehensive Review.
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🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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Alopecia areata.
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Epidemiology and burden of alopecia areata: a systematic review.
TL;DRAA is the most prevalent autoimmune disorder and the second most prevalent hair loss disorder after androgenetic alopecia, and the lifetime risk in the global population is approxi…
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Two Phase 3 Trials of Baricitinib for Alopecia Areata.
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Treatment options for androgenetic alopecia: Efficacy, side effects, compliance, financial considerations, and ethics.
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Hair follicle immune privilege and its collapse in alopecia areata.
TL;DRA key goal for effective AA management is the re‐establishment of a functional HF IP, which will also provide superior protection from disease relapse, and may confer increased sus…