Morphogenesis and renewal of hair follicles from adult multipotent stem cells.
5/5 보강
TL;DR
The results indicate that the clonogenic keratinocytes are closely related, if not identical, to the multipotent stem cells, and that the regulation of whisker growth necessitates a precise control of stem cell trafficking.
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연도별 인용 (2012–2026) · 합계 419
OpenAlex 토픽 ·
Hair Growth and Disorders
Wnt/β-catenin signaling in development and cancer
Skin and Cellular Biology Research
🇰🇷 한글 요약 🌐 Abstract
【연구 목적】
성체 마우스 수염 모낭(vibrissal follicle)의 다능성 줄기세포(multipotent stem cells) 위치와 이동 양상을 규명하고, 모낭 재생 과정에서 줄기세포 동원이 어떻게 조절되는지 밝히고자 함.
【방법】
성체 마우스 수염 모낭의 외측 모근초(outer root sheath) 상부와 하부 영역을 분리하여 형태형성 신호(morphogenetic signals)에 대한 반응성을 평가하고, 클론원성 각질형성세포(clonogenic keratinocytes) 분포를 시기별로 분석함.
【주요 결과】
모낭 상부에는 모낭, 피지선(sebaceous gland), 표피 등 모든 유모피부 계통을 생성할 수 있는 다능성 줄기세포가 존재하며, 모발 생성이 중단되고 모낭 하부가 구조적 변화를 겪는 시점에는 줄기세포가 모낭 뿌리 쪽으로 이동하여 수염 성장을 유도함. 클론원성 각질형성세포는 다능성 줄기세포와 매우 밀접하거나 동일한 세포군으로 추정됨.
【임상적 시사점 (성형외과 의사 관점)】
모낭 상부(bulge 인근)가 모발 재생의 핵심 줄기세포 저장소임을 시사하므로, 모발이식(hair transplantation) 시 모낭 상부 손상을 최소화하는 것이 생착률에 중요함. 흉터 재건 및 탈모 치료에서 줄기세포 이동(stem cell trafficking) 조절 기전을 응용하면 모낭 신생(neogenesis) 유도 치료의 이론적 근거가 될 수 있음.
The upper region of the outer root sheath of vibrissal follicles of adult mice contains multipotent stem cells that respond to morphogenetic signals to generate multiple hair follicles, sebaceous glands, and epidermis, i.e., all the lineages of the hairy skin. At the time when hair production ceases and when the lower region of the follicle undergoes major structural changes, the lower region contains a significant number of clonogenic keratinocytes, and can then respond to morphogenetic signals. This demonstrates that multipotent stem cells migrate to the root of the follicle to produce whisker growth. Moreover, our results indicate that the clonogenic keratinocytes are closely related, if not identical, to the multipotent stem cells, and that the regulation of whisker growth necessitates a precise control of stem cell trafficking.
【연구 목적】 성체 마우스 수염 모낭(vibrissal follicle)의 다능성 줄기세포(multipotent stem cells) 위치와 이동 양상을 규명하고, 모낭 재생 과정에서 줄기세포 동원이 어떻게 조절되는지 밝히고자 함.
APA 7
Oshima, H., Rochat, A., Kedzia, C., Kobayashi, K., & Barrandon, Y. (2001). Morphogenesis and renewal of hair follicles from adult multipotent stem cells.. Cell, 104(2), 233-45. https://doi.org/10.1016/s0092-8674(01)00208-2
Vancouver
Oshima H, Rochat A, Kedzia C, Kobayashi K, Barrandon Y. Morphogenesis and renewal of hair follicles from adult multipotent stem cells. Cell. 2001;104(2):233-45. doi:10.1016/s0092-8674(01)00208-2
AMA 11
Oshima H, Rochat A, Kedzia C, Kobayashi K, Barrandon Y. Morphogenesis and renewal of hair follicles from adult multipotent stem cells. Cell. 2001;104(2):233-45. doi:10.1016/s0092-8674(01)00208-2
Chicago
Oshima, H., Rochat, A., Kedzia, C., Kobayashi, K., and Barrandon, Y.. 2001. "Morphogenesis and renewal of hair follicles from adult multipotent stem cells." Cell 104 (2): 233-45. https://doi.org/10.1016/s0092-8674(01)00208-2
MLA 9
Oshima, H., et al. "Morphogenesis and renewal of hair follicles from adult multipotent stem cells." Cell, vol. 104, no. 2, 2001, pp. 233-45. doi:10.1016/s0092-8674(01)00208-2.
PMID
11207364 ↗
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Animals
- Cell Lineage
- Cell Movement
- Cells
- Cultured
- Chimera
- Colony-Forming Units Assay
- Embryo
- Mammalian
- Epidermal Cells
- Epidermis
- Female
- Genes
- Reporter
- Hair Follicle
- Immunohistochemistry
- Keratinocytes
- Male
- Mice
- Inbred Strains
- Morphogenesis
- Rats
- Inbred F344
- Stem Cells
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