Sonic hedgehog signaling is essential for hair development.
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TL;DR
F follicle development in the Shh mutant embryo arrested after the initial epidermal-dermal interactions that lead to the formation of a dermal papilla anlage and ingrowth of the epidermis, suggesting that Shh signaling is essential, however, for controlling ingrowth and morphogenesis of the hair follicle.
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연도별 인용 (2012–2026) · 합계 356
OpenAlex 토픽 ·
Hair Growth and Disorders
Hedgehog Signaling Pathway Studies
Cancer and Skin Lesions
🇰🇷 한글 요약 🌐 Abstract
【연구 목적】
Sonic hedgehog(Shh) 신호가 모낭(hair follicle) 발달에서 어떤 역할을 하는지 규명하기 위해, Shh 결손(null mutant) 생쥐 모델에서 모낭 형성 과정을 분석하였다.
【방법】
Shh 유전자 결손 생쥐 배아의 피부에서 모낭 발달 단계와 Wnt10b, Bmp2, Bmp4 발현 양상을 관찰하였고, 결손 피부를 누드마우스에 이식(graft)하여 장기간 모낭 발달 및 모발 형성 여부를 평가하였다.
【주요 결과】
Shh 결손 배아에서도 초기 상피-간엽 상호작용(epithelial-mesenchymal interaction)과 진피유두(dermal papilla) 원기 형성, 표피 함입(ingrowth)은 진행되었고 Wnt10b·Bmp2·Bmp4 발현도 유지되었다. 그러나 이후 모낭 형태형성이 정지되었으며, 이식 시 비정상적으로 큰 모낭과 작은 진피유두가 형성되고 모간(hair shaft) 유사 분화는 일부 관찰되었으나 실제 모발은 만들어지지 않았다.
【임상적 시사점 (성형외과 의사 관점)】
Shh 신호는 모낭의 시작이 아니라 함입·형태형성 단계에서 필수적이므로, 모발이식·재생 치료에서 Shh 경로 활성화는 모낭의 후기 성장과 모간 형성을 촉진하는 유망한 타깃이 될 수 있다. 다만 Shh는 기저세포암(BCC) 등 종양 발생과 직결되는 경로이므로, 임상 응용 시 국소적·시간 제한적 활성화 전략과 안전성 모니터링이 반드시 동반되어야 한다.
[BACKGROUND] The skin is responsible for forming a variety of epidermal structures that differ amongst vertebrates. In each case the specific structure (for example scale, feather or hair) arises from an epidermal placode as a result of epithelial-mesenchymal interactions with the underlying dermal mesenchyme. Expression of members of the Wnt, Hedgehog and bone morphogenetic protein families (Wnt10b, Sonic hedgehog (Shh) and Bmp2/Bmp4, respectively) in the epidermis correlates with the initiation of hair follicle formation. Further, their expression continues into either the epidermally derived hair matrix which forms the hair itself, or the dermal papilla which is responsible for induction of the hair matrix. To address the role of Shh in the hair follicle, we have examined Shh null mutant mice.
[RESULTS] We found that follicle development in the Shh mutant embryo arrested after the initial epidermal-dermal interactions that lead to the formation of a dermal papilla anlage and ingrowth of the epidermis. Wnt10b, Bmp2 and Bmp4 continued to be expressed at this time, however. When grafted to nude mice (which lack T cells), Shh mutant skin gave rise to large abnormal follicles containing a small dermal papilla. Although these follicles showed high rates of proliferation and some differentiation of hair matrix cells into hair-shaft-like material, no hair was formed.
[CONCLUSIONS] Shh signaling is not required for initiating hair follicle development. Shh signaling is essential, however, for controlling ingrowth and morphogenesis of the hair follicle.
[RESULTS] We found that follicle development in the Shh mutant embryo arrested after the initial epidermal-dermal interactions that lead to the formation of a dermal papilla anlage and ingrowth of the epidermis. Wnt10b, Bmp2 and Bmp4 continued to be expressed at this time, however. When grafted to nude mice (which lack T cells), Shh mutant skin gave rise to large abnormal follicles containing a small dermal papilla. Although these follicles showed high rates of proliferation and some differentiation of hair matrix cells into hair-shaft-like material, no hair was formed.
[CONCLUSIONS] Shh signaling is not required for initiating hair follicle development. Shh signaling is essential, however, for controlling ingrowth and morphogenesis of the hair follicle.
【연구 목적】 Sonic hedgehog(Shh) 신호가 모낭(hair follicle) 발달에서 어떤 역할을 하는지 규명하기 위해, Shh 결손(null mutant) 생쥐 모델에서 모낭 형성 과정을 분석하였다.
APA 7
St-Jacques, B., Dassule, H. R., Karavanova, I., Botchkarev, V. A., Li, J., Danielian, P. S., McMahon, J. A., Lewis, P. M., Paus, R., & McMahon, A. P. (1998). Sonic hedgehog signaling is essential for hair development.. Current biology : CB, 8(19), 1058-68. https://doi.org/10.1016/s0960-9822(98)70443-9
Vancouver
St-Jacques B, Dassule HR, Karavanova I, Botchkarev VA, Li J, Danielian PS, et al. Sonic hedgehog signaling is essential for hair development. Current biology : CB. 1998;8(19):1058-68. doi:10.1016/s0960-9822(98)70443-9
AMA 11
St-Jacques B, Dassule HR, Karavanova I, Botchkarev VA, Li J, Danielian PS, et al. Sonic hedgehog signaling is essential for hair development. Current biology : CB. 1998;8(19):1058-68. doi:10.1016/s0960-9822(98)70443-9
Chicago
St-Jacques, B., Dassule, H. R., Karavanova, I., Botchkarev, V. A., Li, J., Danielian, P. S., McMahon, J. A., Lewis, P. M., Paus, R., and McMahon, A. P.. 1998. "Sonic hedgehog signaling is essential for hair development." Current biology : CB 8 (19): 1058-68. https://doi.org/10.1016/s0960-9822(98)70443-9
MLA 9
St-Jacques, B., et al. "Sonic hedgehog signaling is essential for hair development." Current biology : CB, vol. 8, no. 19, 1998, pp. 1058-68. doi:10.1016/s0960-9822(98)70443-9.
PMID
9768360 ↗
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
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