The aging skin microenvironment dictates stem cell behavior.
4/5 보강
TL;DR
Using murine skin, single-cell RNA-sequencing is employed with functional studies to examine age-related changes of hair follicle (HF) SCs and their microenvironment (“niche”) that together govern hair regeneration, and highlights the importance of SC:niche interactions.
📑 코퍼스 인용 관계
· 인용됨 25 · 인용함 92
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연도별 인용 (2020–2026) · 합계 186
OpenAlex 토픽 ·
Hair Growth and Disorders
Skin Protection and Aging
melanin and skin pigmentation
Abstract 🌐 Abstract
Aging manifests with architectural alteration and functional decline of multiple organs throughout an organism. In mammals, aged skin is accompanied by a marked reduction in hair cycling and appearance of bald patches, leading researchers to propose that hair follicle stem cells (HFSCs) are either lost, differentiate, or change to an epidermal fate during aging. Here, we employed single-cell RNA-sequencing to interrogate aging-related changes in the HFSCs. Surprisingly, although numbers declined, aging HFSCs were present, maintained their identity, and showed no overt signs of shifting to an epidermal fate. However, they did exhibit prevalent transcriptional changes particularly in extracellular matrix genes, and this was accompanied by profound structural perturbations in the aging SC niche. Moreover, marked age-related changes occurred in many nonepithelial cell types, including resident immune cells, sensory neurons, and arrector pili muscles. Each of these SC niche components has been shown to influence HF regeneration. When we performed skin injuries that are known to mobilize young HFSCs to exit their niche and regenerate HFs, we discovered that aged skin is defective at doing so. Interestingly, however, in transplantation assays in vivo, aged HFSCs regenerated HFs when supported with young dermis, while young HFSCs failed to regenerate HFs when combined with aged dermis. Together, our findings highlight the importance of SC:niche interactions and favor a model where youthfulness of the niche microenvironment plays a dominant role in dictating the properties of its SCs and tissue health and fitness.
Using murine skin, single-cell RNA-sequencing is employed with functional studies to examine age-related changes of hair follicle (HF) SCs and their microenvironment (“niche”) that together govern hai
APA 7
Ge, Y., Miao, Y., Gur-Cohen, S., Gomez, N., Yang, H., Nikolova, M., Polak, L., Hu, Y., Verma, A., Elemento, O., Krueger, J. G., & Fuchs, E. (2020). The aging skin microenvironment dictates stem cell behavior.. Proceedings of the National Academy of Sciences of the United States of America, 117(10), 5339-5350. https://doi.org/10.1073/pnas.1901720117
Vancouver
Ge Y, Miao Y, Gur-Cohen S, Gomez N, Yang H, Nikolova M, et al. The aging skin microenvironment dictates stem cell behavior. Proc. Nati. Acad. Scie. Unit. Stat. Amer.. 2020;117(10):5339-5350. doi:10.1073/pnas.1901720117
AMA 11
Ge Y, Miao Y, Gur-Cohen S, Gomez N, Yang H, Nikolova M, et al. The aging skin microenvironment dictates stem cell behavior. Proc. Nati. Acad. Scie. Unit. Stat. Amer.. 2020;117(10):5339-5350. doi:10.1073/pnas.1901720117
Chicago
Ge, Y., Miao, Y., Gur-Cohen, S., Gomez, N., Yang, H., Nikolova, M., Polak, L., Hu, Y., Verma, A., Elemento, O., and .... 2020. "The aging skin microenvironment dictates stem cell behavior." Proceedings of the National Academy of Sciences of the United States of America 117 (10): 5339-5350. https://doi.org/10.1073/pnas.1901720117
MLA 9
Ge, Y., et al. "The aging skin microenvironment dictates stem cell behavior." Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 10, 2020, pp. 5339-5350. doi:10.1073/pnas.1901720117.
PMID
32094197 ↗
추출된 의학 개체 (NER)
전체 NER 표 보기
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 해부 | hair follicle
|
모낭 | dict | 1 | |
| 해부 | hair follicle
|
모낭 | dict | 1 |
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
인용 관계
그래프 OA 노드: 13/16 (81%)
· 참조 7편 · 후속 6편
이 논문이 참조한 문헌 50
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- Epithelial-Mesenchymal Micro-niches Govern Stem Cell Lineage Choices.
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- Pioneer factors govern super-enhancer dynamics in stem cell plasticity and lineage choice.
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- Stem Cell Lineage Infidelity Drives Wound Repair and Cancer.
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- Reconstitution of hair follicle development in vivo: determination of follicle formation, hair growt…
- STEM CELLS. Aging, alopecia, and stem cells.
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- Defining stem cell dynamics and migration during wound healing in mouse skin epidermis.
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외부 PMID 30건 (DB 미수집)
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- PMID 21549329 ↗
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이 논문을 인용한 후속 연구 20
- Functional hair follicle regeneration: an updated review.
- Local and systemic mechanisms that control the hair follicle stem cell niche.
- Deciphering the molecular mechanisms of stem cell dynamics in hair follicle regeneration.
- Stem cell-intrinsic mechanisms regulating adult hair follicle homeostasis.
- Hair follicle stem cells as a skin-organizing signaling center during adult homeostasis.
- Aging of hair follicle stem cells and their niches.
- Niche stiffening compromises hair follicle stem cell potential during ageing by reducing bivalent pr…
- MicroRNA-205 promotes hair regeneration by modulating mechanical properties of hair follicle stem ce…
- Stem cell activity-coupled suppression of endogenous retrovirus governs adult tissue regeneration.
- Mapping the molecular and structural specialization of the skin basement membrane for inter-tissue i…
- A Wnt5a-Cdc42 axis controls aging and rejuvenation of hair-follicle stem cells.
- TLR9 activation in large wound induces tissue repair and hair follicle regeneration via γδT cells.
- Innate type 2 immunity controls hair follicle commensalism by Demodex mites.
- Single cell analysis of transcriptome and open chromatin reveals the dynamics of hair follicle stem …
- Cells, growth factors and biomaterials used in tissue engineering for hair follicles regeneration.
- Single-Cell RNA Sequencing Highlights a Contribution of Human Amniotic Mesenchymal Stem Cells-Derive…
- PIEZO1-mediated calcium signaling reinforces mechanical properties of hair follicle stem cells to pr…
- 3D bioprinting of prefabricated artificial skin with multicomponent hydrogel for skin and hair folli…
- Biological and mechanical influence of three-dimensional microenvironment formed in microwell on mul…
- Mechanotransductive Differentiation of Hair Follicle Stem Cells Derived from Aged Eyelid Skin into C…
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🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
📖 비슷한 OA 논문 — 같은 카테고리, 무료 전문 가능
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