FOXC1 maintains the hair follicle stem cell niche and governs stem cell quiescence to preserve long-term tissue-regenerating potential.
4/5 보강
TL;DR
It is suggested that HFSCs have restricted potential in vivo, which they conserve by coupling quiescence to adhesion-mediated niche maintenance, thereby achieving long-term tissue homeostasis.
📑 코퍼스 인용 관계
· 인용됨 39 · 인용함 44
→ 이 논문이 인용한 논문 (6) ▾
- Foxc1 reinforces quiescence in self-renewing hair follicle stem cells. Science (New York, N.Y.) · 2016
- Organ-level quorum sensing directs regeneration in hair stem cell populations. Cell · 2015
- In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration. Nature · 2013
- Adipocyte lineage cells contribute to the skin stem cell niche to drive hair cycling. Cell · 2011
- Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration. Nature · 2008
- NFATc1 balances quiescence and proliferation of skin stem cells. Cell · 2008
📑 인용한 논문 (6) ▾
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- Local and systemic mechanisms that control the hair follicle stem cell niche. Nature reviews. Molecular cell biology · 2024
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연도별 인용 (2016–2026) · 합계 165
OpenAlex 토픽 ·
Hair Growth and Disorders
Cancer and Skin Lesions
Wnt/β-catenin signaling in development and cancer
Abstract 🌐 Abstract
Adult tissue stem cells (SCs) reside in niches, which orchestrate SC behavior. SCs are typically used sparingly and exist in quiescence unless activated for tissue growth. Whether parsimonious SC use is essential to conserve long-term tissue-regenerating potential during normal homeostasis remains poorly understood. Here, we examine this issue by conditionally ablating a key transcription factor Forkhead box C1 (FOXC1) expressed in hair follicle SCs (HFSCs). FOXC1-deficient HFSCs spend less time in quiescence, leading to markedly shortened resting periods between hair cycles. The enhanced hair cycling accelerates HFSC expenditure, and impacts hair regeneration in aging mice. Interestingly, although FOXC1-deficient HFs can still form a new bulge that houses HFSCs for the next hair cycle, the older bulge is left unanchored. As the new hair emerges, the entire old bulge, including its reserve HFSCs and SC-inhibitory inner cell layer, is lost. We trace this mechanism first, to a marked increase in cell cycle-associated transcripts upon Foxc1 ablation, and second, to a downstream reduction in E-cadherin-mediated inter-SC adhesion. Finally, we show that when the old bulge is lost with each hair cycle, overall levels of SC-inhibitory factors are reduced, further lowering the threshold for HFSC activity. Taken together, our findings suggest that HFSCs have restricted potential in vivo, which they conserve by coupling quiescence to adhesion-mediated niche maintenance, thereby achieving long-term tissue homeostasis.
It is suggested that HFSCs have restricted potential in vivo, which they conserve by coupling quiescence to adhesion-mediated niche maintenance, thereby achieving long-term tissue homeostasis.
APA 7
Lay, K., Kume, T., & Fuchs, E. (2016). Foxc1 maintains the hair follicle stem cell niche and governs stem cell quiescence to preserve long-term tissue-regenerating potential.. Proceedings of the National Academy of Sciences of the United States of America, 113(11), E1506-15. https://doi.org/10.1073/pnas.1601569113
Vancouver
Lay K, Kume T, Fuchs E. FOXC1 maintains the hair follicle stem cell niche and governs stem cell quiescence to preserve long-term tissue-regenerating potential. Proc. Nati. Acad. Scie. Unit. Stat. Amer.. 2016;113(11):E1506-15. doi:10.1073/pnas.1601569113
AMA 11
Lay K, Kume T, Fuchs E. FOXC1 maintains the hair follicle stem cell niche and governs stem cell quiescence to preserve long-term tissue-regenerating potential. Proc. Nati. Acad. Scie. Unit. Stat. Amer.. 2016;113(11):E1506-15. doi:10.1073/pnas.1601569113
Chicago
Lay, K., Kume, T., and Fuchs, E.. 2016. "FOXC1 maintains the hair follicle stem cell niche and governs stem cell quiescence to preserve long-term tissue-regenerating potential." Proceedings of the National Academy of Sciences of the United States of America 113 (11): E1506-15. https://doi.org/10.1073/pnas.1601569113
MLA 9
Lay, K., et al. "FOXC1 maintains the hair follicle stem cell niche and governs stem cell quiescence to preserve long-term tissue-regenerating potential." Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 11, 2016, pp. E1506-15. doi:10.1073/pnas.1601569113.
PMID
26912458 ↗
추출된 의학 개체 (NER)
전체 NER 표 보기
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 해부 | hair follicle
|
모낭 | dict | 2 | |
| 해부 | hair follicle
|
모낭 | dict | 2 | |
| 해부 | hair follicle
|
모낭 | dict | 2 |
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
인용 관계
그래프 OA 노드: 14/15 (93%)
· 참조 7편 · 후속 7편
이 논문이 참조한 문헌 37
- Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration.
- Adipocyte lineage cells contribute to the skin stem cell niche to drive hair cycling.
- NFATc1 balances quiescence and proliferation of skin stem cells.
- Lhx2 maintains stem cell character in hair follicles.
- Organ-level quorum sensing directs regeneration in hair stem cell populations.
- Foxc1 reinforces quiescence in self-renewing hair follicle stem cells.
- In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration.
외부 PMID 30건 (DB 미수집)
- PMID 10220414 ↗
- PMID 10411913 ↗
- PMID 10660044 ↗
- PMID 11442744 ↗
- PMID 1176877 ↗
- PMID 12049767 ↗
- PMID 12230507 ↗
- PMID 14704278 ↗
- PMID 15339667 ↗
- PMID 17377529 ↗
- PMID 1785043 ↗
- PMID 17934449 ↗
- PMID 18094733 ↗
- PMID 18202695 ↗
- PMID 18295578 ↗
- PMID 18846253 ↗
- PMID 19200804 ↗
- PMID 19329995 ↗
- PMID 19340011 ↗
- PMID 20806356 ↗
- PMID 21215372 ↗
- PMID 21376238 ↗
- PMID 21610251 ↗
- PMID 22266760 ↗
- PMID 22383036 ↗
- PMID 22522965 ↗
- PMID 23698583 ↗
- PMID 24282298 ↗
- PMID 24384813 ↗
- PMID 24995988 ↗
이 논문을 인용한 후속 연구 20
- Tissue engineering of human hair follicles using a biomimetic developmental approach.
- Corticosterone inhibits GAS6 to govern hair follicle stem-cell quiescence.
- Local and systemic mechanisms that control the hair follicle stem cell niche.
- A systematic summary of survival and death signalling during the life of hair follicle stem cells.
- Cell Types Promoting Goosebumps Form a Niche to Regulate Hair Follicle Stem Cells.
- Concise Review: Mechanisms of Quiescent Hair Follicle Stem Cell Regulation.
- The aging skin microenvironment dictates stem cell behavior.
- Exosomal Micro RNAs Derived from Dermal Papilla Cells Mediate Hair Follicle Stem Cell Proliferation …
- Deciphering the molecular mechanisms of stem cell dynamics in hair follicle regeneration.
- SIRT7 activates quiescent hair follicle stem cells to ensure hair growth in mice.
- Stem cell-intrinsic mechanisms regulating adult hair follicle homeostasis.
- Conventional and novel stem cell based therapies for androgenic alopecia.
- Epidermal E-Cadherin Dependent β-Catenin Pathway Is Phytochemical Inducible and Accelerates Anagen H…
- Photobiomodulation therapy for hair regeneration: A synergetic activation of β-CATENIN in hair folli…
- NFI transcription factors provide chromatin access to maintain stem cell identity while preventing u…
- Androgens trigger different growth responses in genetically identical human hair follicles in organ …
- Aging of hair follicle stem cells and their niches.
- Hair follicle epidermal stem cells define a niche for tactile sensation.
- Quiescent Tissue Stem Cells Evade Immune Surveillance.
- Gata6 promotes hair follicle progenitor cell renewal by genome maintenance during proliferation.
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