Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration.
5/5 보강
TL;DR
Results show that BMPs may be the long-sought ‘chalone’ inhibitors of hair growth postulated by classical experiments, and provide an example of hierarchical regulation of local organ stem cell homeostasis by the inter-organ macroenvironment.
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연도별 인용 (2012–2026) · 합계 662
OpenAlex 토픽 ·
Hair Growth and Disorders
Wnt/β-catenin signaling in development and cancer
Cancer and Skin Lesions
🇰🇷 한글 요약 🌐 Abstract
【연구 목적】
모낭 줄기세포(hair follicle stem cell)의 주기적 활성화 기전을 규명하고, 모발 재생 사이클(hair cycle)에서 진피(dermis) 미세환경이 줄기세포 활성을 어떻게 조절하는지 밝히고자 함.
【방법】
성체 마우스 피부에서 Bmp2/Bmp4 발현 패턴을 시간에 따라 분석하고, BMP 길항제 노긴(noggin) 과발현 형질전환 마우스 모델과 야생형 숙주 간 피부 이식 실험, BMP4 단백질 국소 투여 실험을 시행하여 모발 재생파(regenerative wave) 변화를 관찰함.
【주요 결과】
진피에서 BMP2/BMP4가 WNT/β-catenin 사이클과 반대 위상으로 주기적 발현되어, 휴지기(telogen)를 BMP 고발현 불응기(refractory phase)와 저발현 가용기(competent phase)로 세분화함. 노긴 과발현 시 불응기가 단축되고 재생파가 빠르게 전파되었으며, BMP4 투여는 가용기를 불응기로 전환시킴. 또한 피하 지방세포(subcutaneous adipocyte)에서 Bmp2가 발현되어 모낭과 지방조직 간 상호조절을 확인함.
【임상적 시사점 (성형외과 의사 관점)】
탈모 치료 및 모발이식(hair transplantation) 시 수여부 피부의 BMP 활성도(불응기/가용기)에 따라 생착률과 발모 시기가 달라질 수 있으므로, BMP 길항 경로 조절이 새로운 발모 촉진 표적이 될 수 있음. 또한 피하 지방층이 모낭 사이클에 직접 관여하므로, 지방이식(fat grafting)이나 SVF(stromal vascular fraction) 시술이 모발 재생에 보조적 효과를 가질 수 있음을 시사함. 줄기세포 기반 모발재생 치료 시 시술 부위의 주기적 환경 차이를 고려한 타이밍 전략이 필요함.
In the age of stem cell engineering it is critical to understand how stem cell activity is regulated during regeneration. Hairs are mini-organs that undergo cyclic regeneration throughout adult life, and are an important model for organ regeneration. Hair stem cells located in the follicle bulge are regulated by the surrounding microenvironment, or niche. The activation of such stem cells is cyclic, involving periodic beta-catenin activity. In the adult mouse, regeneration occurs in waves in a follicle population, implying coordination among adjacent follicles and the extrafollicular environment. Here we show that unexpected periodic expression of bone morphogenetic protein 2 (Bmp2) and Bmp4 in the dermis regulates this process. This BMP cycle is out of phase with the WNT/beta-catenin cycle, thus dividing the conventional telogen into new functional phases: one refractory and the other competent for hair regeneration, characterized by high and low BMP signalling, respectively. Overexpression of noggin, a BMP antagonist, in mouse skin resulted in a markedly shortened refractory phase and faster propagation of the regenerative wave. Transplantation of skin from this mutant onto a wild-type host showed that follicles in donor and host can affect their cycling behaviours mutually, with the outcome depending on the equilibrium of BMP activity in the dermis. Administration of BMP4 protein caused the competent region to become refractory. These results show that BMPs may be the long-sought 'chalone' inhibitors of hair growth postulated by classical experiments. Taken together, results presented in this study provide an example of hierarchical regulation of local organ stem cell homeostasis by the inter-organ macroenvironment. The expression of Bmp2 in subcutaneous adipocytes indicates physiological integration between these two thermo-regulatory organs. Our findings have practical importance for studies using mouse skin as a model for carcinogenesis, intra-cutaneous drug delivery and stem cell engineering studies, because they highlight the acute need to differentiate supportive versus inhibitory regions in the host skin.
【연구 목적】 모낭 줄기세포(hair follicle stem cell)의 주기적 활성화 기전을 규명하고, 모발 재생 사이클(hair cycle)에서 진피(dermis) 미세환경이 줄기세포 활성을 어떻게 조절하는지 밝히고자 함.
APA 7
Plikus, M. V., Mayer, J. A., D, d. l. C., Baker, R. E., Maini, P. K., Maxson, R., & Chuong, C. M. (2008). Cyclic dermal bmp signalling regulates stem cell activation during hair regeneration.. Nature, 451(7176), 340-4. https://doi.org/10.1038/nature06457
Vancouver
Plikus MV, Mayer JA, D dlC, Baker RE, Maini PK, Maxson R, et al. Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration. Nature. 2008;451(7176):340-4. doi:10.1038/nature06457
AMA 11
Plikus MV, Mayer JA, D dlC, Baker RE, Maini PK, Maxson R, et al. Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration. Nature. 2008;451(7176):340-4. doi:10.1038/nature06457
Chicago
Plikus, M. V., Mayer, J. A., D, d. l. C., Baker, R. E., Maini, P. K., Maxson, R., and Chuong, C. M.. 2008. "Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration." Nature 451 (7176): 340-4. https://doi.org/10.1038/nature06457
MLA 9
Plikus, M. V., et al. "Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration." Nature, vol. 451, no. 7176, 2008, pp. 340-4. doi:10.1038/nature06457.
PMID
18202659 ↗
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
인용 관계
그래프 OA 노드: 7/8 (88%)
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