Foxc1 reinforces quiescence in self-renewing hair follicle stem cells.
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TL;DR
It is shown that murine hair follicle SCs induce the Foxc1 transcription factor when activated, which reveals a dynamic, cell-intrinsic mechanism used by hair follicles SCs to reinforce quiescence upon self-renewal and suggest a unique ability ofSCs to maintain cell identity.
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연도별 인용 (2016–2026) · 합계 145
OpenAlex 토픽 ·
Hair Growth and Disorders
Skin and Cellular Biology Research
Cancer and Skin Lesions
It is shown that murine hair follicle SCs induce the Foxc1 transcription factor when activated, which reveals a dynamic, cell-intrinsic mechanism used by hair follicles SCs to reinforce quiescence upo
APA
Li Wang, Julie A. Siegenthaler, et al. (2016). Foxc1 reinforces quiescence in self-renewing hair follicle stem cells.. Science (New York, N.Y.), 351(6273), 613-7. https://doi.org/10.1126/science.aad5440
MLA
Li Wang, et al.. "Foxc1 reinforces quiescence in self-renewing hair follicle stem cells.." Science (New York, N.Y.), vol. 351, no. 6273, 2016, pp. 613-7.
PMID
26912704 ↗
Abstract 한글 요약
Stem cell quiescence preserves the cell reservoir by minimizing cell division over extended periods of time. Self-renewal of quiescent stem cells (SCs) requires the reentry into the cell cycle. In this study, we show that murine hair follicle SCs induce the Foxc1 transcription factor when activated. Deleting Foxc1 in activated, but not quiescent, SCs causes failure of the cells to reestablish quiescence and allows premature activation. Deleting Foxc1 in the SC niche of gene-targeted mice leads to loss of the old hair without impairing quiescence. In self-renewing SCs, Foxc1 activates Nfatc1 and bone morphogenetic protein (BMP) signaling, two key mechanisms that govern quiescence. These findings reveal a dynamic, cell-intrinsic mechanism used by hair follicle SCs to reinforce quiescence upon self-renewal and suggest a unique ability of SCs to maintain cell identity.
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전체 NER 표 보기
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 해부 | hair follicle
|
모낭 | dict | 3 | |
| 해부 | hair follicle
|
모낭 | dict | 3 |
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
인용 관계
그래프 OA 노드: 8/8 (100%)
· 참조 0편 · 후속 8편
이 논문을 인용한 후속 연구 20
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