Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis.
4/5 보강
TL;DR
The fate analysis of HFSCs during aging revealed that organ aging is primed by the sustained DNA damage response against DNA damage that accumulates in renewing stem cells during aging.
📑 코퍼스 인용 관계
· 인용됨 77
📑 인용한 논문 (6) ▾
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연도별 인용 (2016–2026) · 합계 386
OpenAlex 토픽 ·
Hair Growth and Disorders
melanin and skin pigmentation
Skin Protection and Aging
Abstract 🌐 Abstract
Hair thinning and loss are prominent aging phenotypes but have an unknown mechanism. We show that hair follicle stem cell (HFSC) aging causes the stepwise miniaturization of hair follicles and eventual hair loss in wild-type mice and in humans. In vivo fate analysis of HFSCs revealed that the DNA damage response in HFSCs causes proteolysis of type XVII collagen (COL17A1/BP180), a critical molecule for HFSC maintenance, to trigger HFSC aging, characterized by the loss of stemness signatures and by epidermal commitment. Aged HFSCs are cyclically eliminated from the skin through terminal epidermal differentiation, thereby causing hair follicle miniaturization. The aging process can be recapitulated by Col17a1 deficiency and prevented by the forced maintenance of COL17A1 in HFSCs, demonstrating that COL17A1 in HFSCs orchestrates the stem cell-centric aging program of the epithelial mini-organ.
The fate analysis of HFSCs during aging revealed that organ aging is primed by the sustained DNA damage response against DNA damage that accumulates in renewing stem cells during aging.
APA 7
Matsumura, H., Mohri, Y., Binh, N. T., Morinaga, H., Fukuda, M., Ito, M., Kurata, S., Hoeijmakers, J., & Nishimura, E. K. (2016). Hair follicle aging is driven by transepidermal elimination of stem cells via col17a1 proteolysis.. Science (New York, N.Y.), 351(6273), aad4395. https://doi.org/10.1126/science.aad4395
Vancouver
Matsumura H, Mohri Y, Binh NT, Morinaga H, Fukuda M, Ito M, et al. Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis. Science (New York, N.Y.). 2016;351(6273):aad4395. doi:10.1126/science.aad4395
AMA 11
Matsumura H, Mohri Y, Binh NT, Morinaga H, Fukuda M, Ito M, et al. Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis. Science (New York, N.Y.). 2016;351(6273):aad4395. doi:10.1126/science.aad4395
Chicago
Matsumura, H., Mohri, Y., Binh, N. T., Morinaga, H., Fukuda, M., Ito, M., Kurata, S., Hoeijmakers, J., and Nishimura, E. K.. 2016. "Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis." Science (New York, N.Y.) 351 (6273): aad4395. https://doi.org/10.1126/science.aad4395
MLA 9
Matsumura, H., et al. "Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis." Science (New York, N.Y.), vol. 351, no. 6273, 2016, pp. aad4395. doi:10.1126/science.aad4395.
PMID
26912707 ↗
추출된 의학 개체 (NER)
전체 NER 표 보기
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 해부 | hair follicle
|
모낭 | dict | 3 | |
| 해부 | hair follicle
|
모낭 | dict | 3 |
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
인용 관계
그래프 OA 노드: 7/8 (88%)
· 참조 0편 · 후속 7편
이 논문을 인용한 후속 연구 20
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같은 제1저자의 인용 많은 논문 (5)
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🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
- 피나스테리드가 전립선암 발생에 미치는 영향.
- COVID-19의 50가지 이상의 장기 후유증: 체계적 문헌고찰 및 메타분석.
- 양성 전립선 비대증의 임상적 진행에 대한 doxazosin, finasteride 및 병용 요법의 장기 효과.
- 양성 전립선 비대증 환자에서 finasteride의 효과. The Finasteride Study Group.
- 양성 전립선 비대증 남성에서 급성 요폐의 위험과 수술적 치료 필요성에 대한 finasteride의 효과. Finasteride Long-Term Efficacy and Safety Study Group.
- 원형 탈모.
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