Regeneration of fat cells from myofibroblasts during wound healing.
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연도별 인용 (2017–2026) · 합계 566
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Abstract 🌐 Abstract
Although regeneration through the reprogramming of one cell lineage to another occurs in fish and amphibians, it has not been observed in mammals. We discovered in the mouse that during wound healing, adipocytes regenerate from myofibroblasts, a cell type thought to be differentiated and nonadipogenic. Myofibroblast reprogramming required neogenic hair follicles, which triggered bone morphogenetic protein (BMP) signaling and then activation of adipocyte transcription factors expressed during development. Overexpression of the BMP antagonist Noggin in hair follicles or deletion of the BMP receptor in myofibroblasts prevented adipocyte formation. Adipocytes formed from human keloid fibroblasts either when treated with BMP or when placed with human hair follicles in vitro Thus, we identify the myofibroblast as a plastic cell type that may be manipulated to treat scars in humans.
Although regeneration through the reprogramming of one cell lineage to another occurs in fish and amphibians, it has not been observed in mammals.
APA 7
Plikus, M. V., Guerrero-Juarez, C. F., Ito, M., Li, Y. R., Dedhia, P. H., Zheng, Y., Shao, M., Gay, D. L., Ramos, R., Hsi, T. C., Oh, J. W., Wang, X., Ramirez, A., Konopelski, S. E., Elzein, A., Wang, A., Supapannachart, R. J., Lee, H. L., Lim, C. H., Nace, A., & ... (2017). Regeneration of fat cells from myofibroblasts during wound healing.. Science (New York, N.Y.), 355(6326), 748-752. https://doi.org/10.1126/science.aai8792
Vancouver
Plikus MV, Guerrero-Juarez CF, Ito M, Li YR, Dedhia PH, Zheng Y, et al. Regeneration of fat cells from myofibroblasts during wound healing. Science (New York, N.Y.). 2017;355(6326):748-752. doi:10.1126/science.aai8792
AMA 11
Plikus MV, Guerrero-Juarez CF, Ito M, Li YR, Dedhia PH, Zheng Y, et al. Regeneration of fat cells from myofibroblasts during wound healing. Science (New York, N.Y.). 2017;355(6326):748-752. doi:10.1126/science.aai8792
Chicago
Plikus, M. V., Guerrero-Juarez, C. F., Ito, M., Li, Y. R., Dedhia, P. H., Zheng, Y., Shao, M., Gay, D. L., Ramos, R., Hsi, T. C., and .... 2017. "Regeneration of fat cells from myofibroblasts during wound healing." Science (New York, N.Y.) 355 (6326): 748-752. https://doi.org/10.1126/science.aai8792
MLA 9
Plikus, M. V., et al. "Regeneration of fat cells from myofibroblasts during wound healing." Science (New York, N.Y.), vol. 355, no. 6326, 2017, pp. 748-752. doi:10.1126/science.aai8792.
PMID
28059714 ↗
추출된 의학 개체 (NER)
합병증
켈로이드 keloid
전체 NER 표 보기
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 합병증 | keloid
|
켈로이드 | dict | 1 |
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Adipocytes
- Animals
- Bone Morphogenetic Protein 2
- Bone Morphogenetic Protein 4
- Bone Morphogenetic Proteins
- Cells
- Cultured
- Cellular Reprogramming
- Cicatrix
- DNA-Binding Proteins
- Fibroblasts
- Hair Follicle
- Humans
- Mice
- Inbred C57BL
- Myofibroblasts
- Recombinant Proteins
- Regeneration
- Signal Transduction
- Transcription Factors
- Wound Healing
인용 관계
그래프 OA 노드: 8/9 (89%)
· 참조 1편 · 후속 7편
이 논문이 참조한 문헌 22
외부 PMID 21건 (DB 미수집)
- PMID 11118201 ↗
- PMID 13199800 ↗
- PMID 13321965 ↗
- PMID 14976316 ↗
- PMID 17151198 ↗
- PMID 17507982 ↗
- PMID 18801968 ↗
- PMID 20200519 ↗
- PMID 21866153 ↗
- PMID 22143790 ↗
- PMID 22473998 ↗
- PMID 22842476 ↗
- PMID 23018966 ↗
- PMID 23209378 ↗
- PMID 23359679 ↗
- PMID 23727932 ↗
- PMID 24446236 ↗
- PMID 25039994 ↗
- PMID 25883361 ↗
- PMID 26494786 ↗
- PMID 26504521 ↗
이 논문을 인용한 후속 연구 20
- Tissue engineering of human hair follicles using a biomimetic developmental approach.
- Hedgehog stimulates hair follicle neogenesis by creating inductive dermis during murine skin wound h…
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- Hedgehog signaling reprograms hair follicle niche fibroblasts to a hyper-activated state.
- The dermal sheath: An emerging component of the hair follicle stem cell niche.
- Noncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR3.
- Emerging nonmetabolic functions of skin fat.
- Through the lens of hair follicle neogenesis, a new focus on mechanisms of skin regeneration after w…
- The Role of Immature and Mature Adipocytes in Hair Cycling.
- Delayed Hair Follicle Morphogenesis and Hair Follicle Dystrophy in a Lipoatrophy Mouse Model of Ppar…
- Msi2 Maintains Quiescent State of Hair Follicle Stem Cells by Directly Repressing the Hh Signaling P…
- Building and Maintaining the Skin.
- Divergent proliferation patterns of distinct human hair follicle epithelial progenitor niches in sit…
- Anagen hair follicles transplanted into mature human scars remodel fibrotic tissue.
- Regeneration of Dermis: Scarring and Cells Involved.
- Restoration of Immune Privilege in Human Dermal Papillae Controlling Epithelial-Mesenchymal Interact…
- Wound-Induced Hair Neogenesis Model.
- Dermal adipose tissue has high plasticity and undergoes reversible dedifferentiation in mice.
- Msx2 Supports Epidermal Competency during Wound-Induced Hair Follicle Neogenesis.
- TLR9 activation in large wound induces tissue repair and hair follicle regeneration via γδT cells.
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