Lhx2 maintains stem cell character in hair follicles.
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TL;DR
Using gain- and loss-of-function studies, a role for Lhx2 is uncovered in maintaining the growth and undifferentiated properties of hair follicle progenitors.
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연도별 인용 (2012–2026) · 합계 241
OpenAlex 토픽 ·
Hair Growth and Disorders
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Abstract 🌐 Abstract
During embryogenesis, stem cells are set aside to fuel the postnatal hair cycle and repair the epidermis after injury. To define how hair follicle stem cells are specified and maintained in an undifferentiated state, we developed a strategy to isolate and transcriptionally profile embryonic hair progenitors in mice. We identified Lhx2 as a transcription factor positioned downstream of signals necessary to specify hair follicle stem cells, but upstream from signals required to drive activated stem cells to terminally differentiate. Using gain- and loss-of-function studies, we uncovered a role for Lhx2 in maintaining the growth and undifferentiated properties of hair follicle progenitors.
Using gain- and loss-of-function studies, a role for Lhx2 is uncovered in maintaining the growth and undifferentiated properties of hair follicle progenitors.
APA 7
Rhee, H., Polak, L., & Fuchs, E. (2006). Lhx2 maintains stem cell character in hair follicles.. Science (New York, N.Y.), 312(5782), 1946-9. https://doi.org/10.1126/science.1128004
Vancouver
Rhee H, Polak L, Fuchs E. Lhx2 maintains stem cell character in hair follicles. Science (New York, N.Y.). 2006;312(5782):1946-9. doi:10.1126/science.1128004
AMA 11
Rhee H, Polak L, Fuchs E. Lhx2 maintains stem cell character in hair follicles. Science (New York, N.Y.). 2006;312(5782):1946-9. doi:10.1126/science.1128004
Chicago
Rhee, H., Polak, L., and Fuchs, E.. 2006. "Lhx2 maintains stem cell character in hair follicles." Science (New York, N.Y.) 312 (5782): 1946-9. https://doi.org/10.1126/science.1128004
MLA 9
Rhee, H., et al. "Lhx2 maintains stem cell character in hair follicles." Science (New York, N.Y.), vol. 312, no. 5782, 2006, pp. 1946-9. doi:10.1126/science.1128004.
PMID
16809539 ↗
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Animals
- Cell Differentiation
- Cell Lineage
- Cell Proliferation
- Epidermal Cells
- Epidermis
- Female
- Gene Expression Profiling
- Gene Expression Regulation
- Developmental
- Hair
- Hair Follicle
- Homeodomain Proteins
- LIM-Homeodomain Proteins
- Male
- Mice
- Knockout
- Transgenic
- Morphogenesis
- Oligonucleotide Array Sequence Analysis
- Signal Transduction
- Skin Transplantation
- Stem Cells
- Transcription Factors
… 외 1개
인용 관계
그래프 OA 노드: 8/8 (100%)
· 참조 0편 · 후속 8편
이 논문을 인용한 후속 연구 20
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