NFATc1 balances quiescence and proliferation of skin stem cells.
5/5 보강
TL;DR
It is reported here that NFATc1 is preferentially expressed by hair follicle stem cells in their niche, where its expression is activated by BMP signaling upstream and it acts downstream to transcriptionally repress CDK4 and maintain stem cell quiescence.
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📑 인용한 논문 (6) ▾
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- Local and systemic mechanisms that control the hair follicle stem cell niche. Nature reviews. Molecular cell biology · 2024
연도별 인용 (2012–2026) · 합계 317
OpenAlex 토픽 ·
Hair Growth and Disorders
Signaling Pathways in Disease
Wound Healing and Treatments
🇰🇷 한글 요약 🌐 Abstract
【연구 목적】
모낭 줄기세포(hair follicle stem cell)의 휴지기(quiescence)가 어떻게 조절되는지를 규명하고, NFATc1 전사인자의 역할을 분자 수준에서 밝히고자 함.
【방법】
모낭 줄기세포 niche에서의 NFATc1 발현 분석, BMP 신호 상류 조절 확인, CDK4 전사 억제 기전 검증, 그리고 약물(칼시뉴린/NFATc1 억제제, cyclosporine A) 및 NFATc1 유전자 결손(완전·조건부 knockout) 마우스 모델을 통한 표현형 평가.
【주요 결과】
NFATc1은 BMP에 의해 활성화되어 CDK4 발현을 억제함으로써 모낭 줄기세포 휴지기를 유지하며, 모발 성장기 진입 시 하향 조절됨. 칼시뉴린/NFATc1 신호를 약리학적 또는 유전적으로 차단하면 줄기세포가 조기 활성화되어 모낭 성장이 앞당겨짐.
【임상적 시사점 (성형외과 의사 관점)】
이식 환자에서 cyclosporine A 복용 시 관찰되는 다모증(hypertrichosis)의 분자적 기전을 설명하며, 칼시뉴린-NFATc1-CDK4 경로 조절이 향후 탈모(alopecia) 치료 및 모발 이식(hair transplantation) 후 성장 촉진 전략의 새로운 표적이 될 수 있음.
Quiescent adult stem cells reside in specialized niches where they become activated to proliferate and differentiate during tissue homeostasis and injury. How stem cell quiescence is governed is poorly understood. We report here that NFATc1 is preferentially expressed by hair follicle stem cells in their niche, where its expression is activated by BMP signaling upstream and it acts downstream to transcriptionally repress CDK4 and maintain stem cell quiescence. As stem cells become activated during hair growth, NFATc1 is downregulated, relieving CDK4 repression and activating proliferation. When calcineurin/NFATc1 signaling is suppressed, pharmacologically or via complete or conditional NFATc1 gene ablation, stem cells are activated prematurely, resulting in precocious follicular growth. Our findings may explain why patients receiving cyclosporine A for immunosuppressive therapy display excessive hair growth, and unveil a functional role for calcium-NFATc1-CDK4 circuitry in governing stem cell quiescence.
【연구 목적】 모낭 줄기세포(hair follicle stem cell)의 휴지기(quiescence)가 어떻게 조절되는지를 규명하고, NFATc1 전사인자의 역할을 분자 수준에서 밝히고자 함.
APA 7
Horsley, V., Aliprantis, A. O., Polak, L., Glimcher, L. H., & Fuchs, E. (2008). Nfatc1 balances quiescence and proliferation of skin stem cells.. Cell, 132(2), 299-310. https://doi.org/10.1016/j.cell.2007.11.047
Vancouver
Horsley V, Aliprantis AO, Polak L, Glimcher LH, Fuchs E. NFATc1 balances quiescence and proliferation of skin stem cells. Cell. 2008;132(2):299-310. doi:10.1016/j.cell.2007.11.047
AMA 11
Horsley V, Aliprantis AO, Polak L, Glimcher LH, Fuchs E. NFATc1 balances quiescence and proliferation of skin stem cells. Cell. 2008;132(2):299-310. doi:10.1016/j.cell.2007.11.047
Chicago
Horsley, V., Aliprantis, A. O., Polak, L., Glimcher, L. H., and Fuchs, E.. 2008. "NFATc1 balances quiescence and proliferation of skin stem cells." Cell 132 (2): 299-310. https://doi.org/10.1016/j.cell.2007.11.047
MLA 9
Horsley, V., et al. "NFATc1 balances quiescence and proliferation of skin stem cells." Cell, vol. 132, no. 2, 2008, pp. 299-310. doi:10.1016/j.cell.2007.11.047.
PMID
18243104 ↗
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Animals
- Antigens
- CD34
- Biomarkers
- Cell Nucleus
- Cell Proliferation
- Cells
- Cultured
- Cyclin-Dependent Kinase 4
- Cyclosporine
- Down-Regulation
- Embryo
- Mammalian
- Gene Deletion
- Gene Expression
- Gene Expression Regulation
- Developmental
- Genes
- Reporter
- Hair Follicle
- Immunohistochemistry
- Immunosuppressive Agents
- Mice
- Knockout
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