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GATA-3: an unexpected regulator of cell lineage determination in skin.

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Genes & development 📖 저널 OA 100% 2022: 1/1 OA 2023: 1/1 OA 2024: 1/1 OA 2025: 8/8 OA 2026: 13/13 OA 2022~2026 2003 Vol.17(17) p. 2108-22 피인용 25회 cited 362 OA RCR 4.81 Hair Growth and Disorders
TL;DR Findings place GATA-3 with Lef-1/Wnts at the crossroads of the IRS versus hair shaft cell fate decision in hair follicle morphogenesis, and strengthens the parallels between the differentiation programs governinghair follicle and lymphocyte differentiation.
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PubMed DOI PMC OpenAlex Semantic 마지막 보강 2026-05-10
📑 코퍼스 인용 관계 · 인용됨 25
📑 인용한 논문 (6) ▾
연도별 인용 (2012–2026) · 합계 198
OpenAlex 토픽 · Hair Growth and Disorders Cancer and Skin Lesions Wnt/β-catenin signaling in development and cancer

Kaufman CK, Zhou P, Pasolli HA, Rendl M, Bolotin D, Lim KC

📖 무료 전문 🟢 PMC 전문 PMC196453 🔓 OA PDF oa
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Abstract

Multipotent skin stem cells give rise to epidermis and its appendages, including the hair follicle. The Lef-1/Tcf family of Wnt-regulated transcription factors plays a major role in specification of the hair shaft, but little is known about how the equally important hair channel, the inner root sheath (IRS), develops in concert to shape and guide the hair. In a microarray screen to search for transcriptional regulators of hair follicle morphogenesis, we identified GATA-3, a key regulator of T-cell lineage determination. Surprisingly, this transcription factor is essential for stem cell lineage determination in skin, where it is expressed at the onset of epidermal stratification and IRS specification in follicles. GATA-3-null/lacZ knock-in embryos can survive up to embryonic day 18.5 (E18.5), when they fail to form the IRS. Skin grafting unveiled additional defects in GATA-3-null hairs and follicles. IRS progenitors failed to differentiate, whereas cortical progenitors differentiated, but produced an aberrant hair structure. Curiously, some GATA-3-null progenitor cells expressed mixed IRS and hair shaft markers. Taken together, these findings place GATA-3 with Lef-1/Wnts at the crossroads of the IRS versus hair shaft cell fate decision in hair follicle morphogenesis. This newfound function for GATA-3 in skin development strengthens the parallels between the differentiation programs governing hair follicle and lymphocyte differentiation.
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Findings place GATA-3 with Lef-1/Wnts at the crossroads of the IRS versus hair shaft cell fate decision in hair follicle morphogenesis, and strengthens the parallels between the differentiation progra

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↓ .bib ↓ .ris
APA 7 Kaufman, C. K., Zhou, P., Pasolli, H. A., Rendl, M., Bolotin, D., Lim, K. C., Dai, X., Alegre, M. L., & Fuchs, E. (2003). Gata-3: An unexpected regulator of cell lineage determination in skin.. Genes & development, 17(17), 2108-22. https://doi.org/10.1101/gad.1115203
Vancouver Kaufman CK, Zhou P, Pasolli HA, Rendl M, Bolotin D, Lim KC, et al. GATA-3: an unexpected regulator of cell lineage determination in skin. Genes & development. 2003;17(17):2108-22. doi:10.1101/gad.1115203
AMA 11 Kaufman CK, Zhou P, Pasolli HA, Rendl M, Bolotin D, Lim KC, et al. GATA-3: an unexpected regulator of cell lineage determination in skin. Genes & development. 2003;17(17):2108-22. doi:10.1101/gad.1115203
Chicago Kaufman, C. K., Zhou, P., Pasolli, H. A., Rendl, M., Bolotin, D., Lim, K. C., Dai, X., Alegre, M. L., and Fuchs, E.. 2003. "GATA-3: an unexpected regulator of cell lineage determination in skin." Genes & development 17 (17): 2108-22. https://doi.org/10.1101/gad.1115203
MLA 9 Kaufman, C. K., et al. "GATA-3: an unexpected regulator of cell lineage determination in skin." Genes & development, vol. 17, no. 17, 2003, pp. 2108-22. doi:10.1101/gad.1115203.
PMID 12923059 ↗
DOI 10.1101/gad.1115203

🏷️ 키워드 / MeSH 📖 같은 키워드 OA만

인용 관계

그래프 OA 노드: 8/8 (100%) · 참조 0편 · 후속 8편

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🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반

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