Diagnostic and predictive value of horizontal sections of scalp biopsy specimens in male pattern androgenetic alopecia.
💡 한 문장 핵심
남성형 안드로겐성 탈모에서 두피 생검 검체 수평 절편의 진단적 및 예측적 가치.
4/5 보강
TL;DR
Horizontal sections of scalp biopsy specimens in MPAA provide more diagnostic information than vertical sections and appear to have a predictive value for hair regrowth.
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
106 patients with MPAA, for horizontal and vertical sectioning.
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
In MPAA with no significant inflammation, regrowth occurred in 77% of cases, versus 55% in cases with significant inflammation. [CONCLUSION] Horizontal sections of scalp biopsy specimens in MPAA provide more diagnostic information than vertical sections and appear to have a predictive value for hair regrowth.
📑 코퍼스 인용 관계
· 인용됨 45
📑 인용한 논문 (6) ▾
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연도별 인용 (2012–2026) · 합계 219
OpenAlex 토픽 ·
Hair Growth and Disorders
Skin and Cellular Biology Research
Cancer and Skin Lesions
Abstract 🌐 Abstract
[BACKGROUND] Vertical sections of small scalp biopsy specimens are often inadequate for the diagnosis of male pattern androgenetic alopecia (MPAA). Quantitative analysis of follicular structures in horizontal sections can provide more information.
[OBJECTIVES] Our purpose was to establish better diagnostic criteria by comparing horizontal and vertical sections of scalp biopsy specimens from MPAA and normal control subjects and to determine the predictive value of horizontal sections, by relating counts of follicular structures in MPAA to subsequent hair regrowth from topical minoxidil therapy.
[METHODS] Paired 4 mm punch biopsy specimens were taken from 22 normal control subjects and 106 patients with MPAA, for horizontal and vertical sectioning. In horizontal sections, hair bulbs, terminal anagen, catagen and telogen hairs, telogen germinal units, and vellus hairs were counted, as were follicular units and stelae.
[RESULTS] The diagnosis of MPAA was confirmed by finding decreased terminal hairs and increased stelae and vellus hairs. The average horizontal section contained 22 terminal and 13 vellus hairs, a 1.7:1 ratio. Changes compatible with MPAA were found in most vertical and horizontal sections, but horizontal sections were required for follicular counts and showed terminal:vellus hair ratios diagnostic of MPAA in 67% of cases. Of 44 patients treated with topical minoxidil, five with less than 2 follicular structures/mm2 showed no hair regrowth, 32 with 2 to 4 follicular structures/mm2 showed regrowth in 72%, and seven with more than 4 follicular structures/mm2 showed regrowth in 86% of cases. In MPAA with no significant inflammation, regrowth occurred in 77% of cases, versus 55% in cases with significant inflammation.
[CONCLUSION] Horizontal sections of scalp biopsy specimens in MPAA provide more diagnostic information than vertical sections and appear to have a predictive value for hair regrowth.
[OBJECTIVES] Our purpose was to establish better diagnostic criteria by comparing horizontal and vertical sections of scalp biopsy specimens from MPAA and normal control subjects and to determine the predictive value of horizontal sections, by relating counts of follicular structures in MPAA to subsequent hair regrowth from topical minoxidil therapy.
[METHODS] Paired 4 mm punch biopsy specimens were taken from 22 normal control subjects and 106 patients with MPAA, for horizontal and vertical sectioning. In horizontal sections, hair bulbs, terminal anagen, catagen and telogen hairs, telogen germinal units, and vellus hairs were counted, as were follicular units and stelae.
[RESULTS] The diagnosis of MPAA was confirmed by finding decreased terminal hairs and increased stelae and vellus hairs. The average horizontal section contained 22 terminal and 13 vellus hairs, a 1.7:1 ratio. Changes compatible with MPAA were found in most vertical and horizontal sections, but horizontal sections were required for follicular counts and showed terminal:vellus hair ratios diagnostic of MPAA in 67% of cases. Of 44 patients treated with topical minoxidil, five with less than 2 follicular structures/mm2 showed no hair regrowth, 32 with 2 to 4 follicular structures/mm2 showed regrowth in 72%, and seven with more than 4 follicular structures/mm2 showed regrowth in 86% of cases. In MPAA with no significant inflammation, regrowth occurred in 77% of cases, versus 55% in cases with significant inflammation.
[CONCLUSION] Horizontal sections of scalp biopsy specimens in MPAA provide more diagnostic information than vertical sections and appear to have a predictive value for hair regrowth.
Horizontal sections of scalp biopsy specimens in MPAA provide more diagnostic information than vertical sections and appear to have a predictive value for hair regrowth.
APA 7
Whiting, D. A. (1993). Diagnostic and predictive value of horizontal sections of scalp biopsy specimens in male pattern androgenetic alopecia.. Journal of the American Academy of Dermatology, 28(5 Pt 1), 755-63. https://doi.org/10.1016/0190-9622(93)70106-4
Vancouver
Whiting DA. Diagnostic and predictive value of horizontal sections of scalp biopsy specimens in male pattern androgenetic alopecia. Jour. Amer. Acad. Derm.. 1993;28(5 Pt 1):755-63. doi:10.1016/0190-9622(93)70106-4
AMA 11
Whiting DA. Diagnostic and predictive value of horizontal sections of scalp biopsy specimens in male pattern androgenetic alopecia. Jour. Amer. Acad. Derm.. 1993;28(5 Pt 1):755-63. doi:10.1016/0190-9622(93)70106-4
Chicago
Whiting, D. A.. 1993. "Diagnostic and predictive value of horizontal sections of scalp biopsy specimens in male pattern androgenetic alopecia." Journal of the American Academy of Dermatology 28 (5 Pt 1): 755-63. https://doi.org/10.1016/0190-9622(93)70106-4
MLA 9
Whiting, D. A.. "Diagnostic and predictive value of horizontal sections of scalp biopsy specimens in male pattern androgenetic alopecia." Journal of the American Academy of Dermatology, vol. 28, no. 5 Pt 1, 1993, pp. 755-63. doi:10.1016/0190-9622(93)70106-4.
PMID
8496421 ↗
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
인용 관계
그래프 OA 노드: 8/8 (100%)
· 참조 0편 · 후속 8편
이 논문을 인용한 후속 연구 20
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같은 제1저자의 인용 많은 논문 (5)
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- Efficacy and tolerability of finasteride 1 mg in men aged 41 to 60 years with male pattern hair loss.
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