Measuring reversal of hair miniaturization in androgenetic alopecia by follicular counts in horizontal sections of serial scalp biopsies: results of finasteride 1 mg treatment of men and postmenopausal women.
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TL;DR
Finasteride appears to be capable of reversing hair miniaturization in androgenetic alopecia in young to middle-aged men, but not in postmenopausal women.
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📑 인용한 논문 (6) ▾
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연도별 인용 (2012–2025) · 합계 91
OpenAlex 토픽 ·
Hair Growth and Disorders
Nail Diseases and Treatments
Dermatology and Skin Diseases
Abstract 🌐 Abstract
Hair regrowth was evaluated by histologic analysis in men and women treated for androgenetic alopecia, by counting follicles in horizontal sections of scalp biopsies. Serial 4mm punch biopsies were taken at baseline and after 12mo of treatment from the transitional area of hair thinning between normal hair and vertex balding in men, and in an area of frontal/parietal thinning in women. Horizontal sections of reticular and papillary dermis were read by one observer, blinded to patient, treatment, and time. All terminal hair bulbs, terminal anagen and telogen hairs, and vellus and vellus-like miniaturized hairs were counted. Twenty-six men aged 18-41y, comprising 14 on finasteride 1 mg daily and 12 on placebo, and 94 postmenopausal women, aged 41-60y, comprising 44 on finasteride 1 mg daily and 50 on placebo, were evaluated. In the male study, the terminal hairs increased from a mean baseline count of 15.5-20.9 after 12mo of finasteride, versus 17.3-18.3 in the placebo patients. The miniaturized hairs decreased from 26.7 to 23.6 with finasteride versus 21.3-20.3 with placebo. The terminal-to-vellus ratio increased more in the finasteride than in the placebo patients, suggesting some reversal of the miniaturization process with finasteride. In the female study, no significant differences in follicular counts were found between the finasteride and placebo groups after 12mo of treatment. Follicular counts in horizontal sections provide an informative adjunct to noninvasive measures used in hair growth studies. Finasteride appears to be capable of reversing hair miniaturization in androgenetic alopecia in young to middle-aged men, but not in postmenopausal women.
Finasteride appears to be capable of reversing hair miniaturization in androgenetic alopecia in young to middle-aged men, but not in postmenopausal women.
APA 7
Whiting, D. A., Waldstreicher, J., Sanchez, M., & Kaufman, K. D. (1999). Measuring reversal of hair miniaturization in androgenetic alopecia by follicular counts in horizontal sections of serial scalp biopsies: Results of finasteride 1 mg treatment of men and postmenopausal women.. The journal of investigative dermatology. Symposium proceedings, 4(3), 282-4. https://doi.org/10.1038/sj.jidsp.5640230
Vancouver
Whiting DA, Waldstreicher J, Sanchez M, Kaufman KD. Measuring reversal of hair miniaturization in androgenetic alopecia by follicular counts in horizontal sections of serial scalp biopsies: results of finasteride 1 mg treatment of men and postmenopausal women. jour. inve. derm. Symp. proc.. 1999;4(3):282-4. doi:10.1038/sj.jidsp.5640230
AMA 11
Whiting DA, Waldstreicher J, Sanchez M, Kaufman KD. Measuring reversal of hair miniaturization in androgenetic alopecia by follicular counts in horizontal sections of serial scalp biopsies: results of finasteride 1 mg treatment of men and postmenopausal women. jour. inve. derm. Symp. proc.. 1999;4(3):282-4. doi:10.1038/sj.jidsp.5640230
Chicago
Whiting, D. A., Waldstreicher, J., Sanchez, M., and Kaufman, K. D.. 1999. "Measuring reversal of hair miniaturization in androgenetic alopecia by follicular counts in horizontal sections of serial scalp biopsies: results of finasteride 1 mg treatment of men and postmenopausal women." The journal of investigative dermatology. Symposium proceedings 4 (3): 282-4. https://doi.org/10.1038/sj.jidsp.5640230
MLA 9
Whiting, D. A., et al. "Measuring reversal of hair miniaturization in androgenetic alopecia by follicular counts in horizontal sections of serial scalp biopsies: results of finasteride 1 mg treatment of men and postmenopausal women." The journal of investigative dermatology. Symposium proceedings, vol. 4, no. 3, 1999, pp. 282-4. doi:10.1038/sj.jidsp.5640230.
PMID
10674382 ↗
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
인용 관계
그래프 OA 노드: 7/8 (88%)
· 참조 0편 · 후속 7편
이 논문을 인용한 후속 연구 15
- Androgenetic Alopecia: An Update of Treatment Options.
- Finasteride and Its Potential for the Treatment of Female Pattern Hair Loss: Evidence to Date.
- Interventions for female pattern hair loss.
- Hair loss and regeneration performed on animal models.
- Post-Finasteride Syndrome: An Induced Delusional Disorder with the Potential of a Mass Psychogenic I…
- Following historical "tracks" of hair follicle miniaturisation in patterned hair loss: Are elastin b…
- A Comment on the Post-Finasteride Syndrome.
- Genetic Differences between Male and Female Pattern Hair Loss in a Korean Population.
- A Study of the Histopathological Features of Alopecias on Transverse Sections of Scalp Biopsies.
- Vellus-to-terminal Hair Follicle Reconversion Occurs in Male Pattern Balding and is Promoted by Mino…
- How to Deal with the Issues of Fertility, Malignancies, and the Postfinasteride Syndrome while Presc…
- Hair Shedding Evaluation for Alopecia: A Refined Wash Test.
- Non-scarring Alopecias in Iranian Patients: A Histopathological Study With Hair Counts.
- Post-finasteride syndrome - a true clinical entity?
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같은 제1저자의 인용 많은 논문 (5)
- Diagnostic and predictive value of horizontal sections of scalp biopsy specimens in male pattern androgenetic alopecia.
- Possible mechanisms of miniaturization during androgenetic alopecia or pattern hair loss.
- Central centrifugal cicatricial alopecia.
- Male pattern hair loss: current understanding.
- Efficacy and tolerability of finasteride 1 mg in men aged 41 to 60 years with male pattern hair loss.
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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