Double-blind, placebo-controlled evaluation of topical minoxidil in extensive alopecia areata.
무작위 임상시험
4/5 보강
TL;DR
Minoxidil applications were generally well tolerated except for three instances of scalp itching and dermatitis, two of which necessitated discontinuing the medication, and examination of vital signs and laboratory measurements revealed no evidence of systemic effects.
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
환자: extensive patchy alopecia areata had greater than 50% scalp hair loss
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
Examination of vital signs and laboratory measurements revealed no evidence of systemic effects of minoxidil. Seven of the twelve subjects assayed in the minoxidil group had detectable minoxidil serum levels, ranging from 0.4 to 7.5 ng/ml.
📑 코퍼스 인용 관계
· 인용됨 7
📑 인용한 논문 (6) ▾
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- Alopecia Areata: Pathogenesis, Diagnosis, and Therapies. MedComm · 2025
- Treatment Options for Alopecia Areata in Children and Adolescents. Paediatric drugs · 2024
- Alopecia Areata: Burden of Disease, Approach to Treatment, and Current Unmet Needs. Clinical, cosmetic and investigational dermatology · 2023
- Treatments for alopecia areata: a network meta-analysis. The Cochrane database of systematic reviews · 2023
연도별 인용 (2012–2025) · 합계 68
OpenAlex 토픽 ·
Hair Growth and Disorders
Wound Healing and Treatments
Dermatologic Treatments and Research
Minoxidil applications were generally well tolerated except for three instances of scalp itching and dermatitis, two of which necessitated discontinuing the medication, and examination of vital signs
APA
Vera H. Price (1987). Double-blind, placebo-controlled evaluation of topical minoxidil in extensive alopecia areata.. Journal of the American Academy of Dermatology, 16(3 Pt 2), 730-6. https://doi.org/10.1016/s0190-9622(87)70095-4
MLA
Vera H. Price. "Double-blind, placebo-controlled evaluation of topical minoxidil in extensive alopecia areata.." Journal of the American Academy of Dermatology, vol. 16, no. 3 Pt 2, 1987, pp. 730-6.
PMID
3549809 ↗
Abstract 한글 요약
The safety and efficacy of 3% topical minoxidil were evaluated in the treatment of extensive patchy alopecia areata, alopecia totalis, and alopecia universalis. Patients with extensive patchy alopecia areata had greater than 50% scalp hair loss. In this double-blind study, thirty subjects applied minoxidil or placebo to half of the afflicted scalp area twice daily, with overnight petrolatum occlusion, for 1 year. Both male and female subjects, ranging in age from 9 to 65 years, were enrolled, fifteen subjects to each treatment group. Minoxidil applications were generally well tolerated except for three instances of scalp itching and dermatitis, two of which necessitated discontinuing the medication. Hair growth was seen in seven of eleven evaluable subjects (63.6%) in the minoxidil group and in five of fourteen evaluable subjects (35.7%) in the placebo group. Excellent, cosmetically acceptable hair growth was seen in three of eleven minoxidil-treated subjects (27.3%) and in one of fourteen placebo-treated subjects (7.1%). Examination of vital signs and laboratory measurements revealed no evidence of systemic effects of minoxidil. Seven of the twelve subjects assayed in the minoxidil group had detectable minoxidil serum levels, ranging from 0.4 to 7.5 ng/ml.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
인용 관계
그래프 OA 노드: 5/7 (71%)
· 참조 0편 · 후속 5편
이 논문을 인용한 후속 연구 7
- Alopecia Areata: Burden of Disease, Approach to Treatment, and Current Unmet Needs.
- Treatments for alopecia areata: a network meta-analysis.
- Alopecia Areata: Pathogenesis, Diagnosis, and Therapies.
- Treatment Options for Alopecia Areata in Children and Adolescents.
- Alopecia Areata: Understanding the Pathophysiology and Advancements in Treatment Modalities.
- Exploiting Recent Trends in the Treatment of Androgenic Alopecia through Topical Nanocarriers of Min…
- Drug-Induced Liver Failure Following Topical Minoxidil: A Case Report.
같은 제1저자의 인용 많은 논문 (5)
- Treatment of hair loss.
- Androgenetic alopecia in women.
- Lack of efficacy of finasteride in postmenopausal women with androgenetic alopecia.
- Changes in hair weight and hair count in men with androgenetic alopecia, after application of 5% and 2% topical minoxidil, placebo, or no treatment.
- Topical minoxidil (3%) in extensive alopecia areata, including long-term efficacy.