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Botulinum toxin-induced masseter muscle atrophy is associated with impaired autophagic flux without signs of apoptosis in mice.

Cell death discovery 2026 Vol.12(1)

Quezada ER, Blanco N, Llanos P, Criollo A, Chiong M, Buvinic S

PMC 전문 ↗ 원문 ↗ DOI ↗

관련 도메인

보툴리눔독소 주사 Botulinum Toxin Injection

Abstract

Botulinum toxin type A (BoNTA) injection into the masseter muscle is widely used for clinical and esthetic purposes. Masseter muscle atrophy is a secondary effect of transient neuromuscular blockade induced by BoNTA. While muscle atrophy has been linked to enhanced ubiquitin-proteasome system activity, leading to increased protein degradation, the role of other catabolic pathways, such as apoptosis and autophagy, remains understudied. In the present study, we evaluated these cellular processes in a mice model of unilateral injection of BoNTA in the masseter muscle, and its relationship with muscle atrophy. Changes in neither molecular markers of apoptosis (cleaved caspase-3, cleaved PARP) nor DNA fragmentation were observed in BoNTA-injected muscles. Conversely, a significant accumulation of the autophagy markers microtubule-associated proteins 1 A/1B light chain 3B (LC3), sequestosome 1 (SQSTM1/p62), and BCL2-associated athanogene 3 (BAG3), along with a reduction in muscle fiber diameter, was observed at 7 days post-BoNTA. These changes were not affected by autophagic flux blockade with chloroquine. Interestingly, LC3 accumulation positively correlates with masseter mass reduction induced by BoNTA. These findings suggest that BoNTA disrupts skeletal muscle homeostasis, promoting atrophy through impaired autophagic activity. Our results not only shed light on the mechanism of BoNTA-induced muscle atrophy but also has broader implications for understanding and potentially treating a range of muscle wasting disorders.

추출된 의학 개체 (NER)

유형영어 표현한국어 / 풀이UMLS CUI출처등장
시술 botulinum toxin 보툴리눔독소 주사 dict 2
해부 masseter muscle scispacy 1
해부 Masseter muscle atrophy scispacy 1
해부 muscle scispacy 1
해부 cellular scispacy 1
해부 DNA scispacy 1
해부 muscle fiber scispacy 1
해부 masseter scispacy 1
해부 skeletal muscle scispacy 1
약물 BoNTA → Botulinum toxin type A C0006050
botulinum toxin type A
 scispacy 1
약물 chloroquine C0008269
chloroquine
 scispacy 1
질환 masseter muscle atrophy C3670700
Masseter muscle atrophy
 scispacy 1
질환 transient neuromuscular blockade scispacy 1
질환 muscle atrophy C0026846
Muscular Atrophy
 scispacy 1
질환 masseter mass reduction scispacy 1
질환 atrophy C0333641
Atrophic
 scispacy 1
질환 muscle wasting disorders C0026846
Muscular Atrophy
 scispacy 1
질환 post-BoNTA scispacy 1
기타 Botulinum toxin-induced scispacy 1
기타 mice scispacy 1
기타 BoNTA → Botulinum toxin type A scispacy 1
기타 caspase-3 scispacy 1
기타 PARP scispacy 1
기타 muscles scispacy 1
기타 A/1B light chain 3B scispacy 1
기타 LC3 → light chain 3B scispacy 1
기타 sequestosome 1 scispacy 1
기타 SQSTM1/p62 scispacy 1
기타 BCL2-associated athanogene 3 scispacy 1
기타 BAG3 → BCL2-associated athanogene 3 scispacy 1

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외부 PMID 30건 (DB 미수집)

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