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Potential Role of Botulinum Neurotoxin Type A as a Supportive Intervention for Depressive Symptoms: A Systematic Review.

Aesthetic plastic surgery 2026 Vol.50(3) p. 1329-1339

Altamura G, Marziali E, Puleo V, Cassotta G, Panebianco A, Visconti AS

원문 ↗ DOI ↗

관련 도메인

보툴리눔독소 주사 Botulinum Toxin Injection

Abstract

[BACKGROUND] Depression is a major global health issue. Recent studies suggest that botulinum toxin (BoNT/A), commonly used in aesthetic procedures, might have potential as an adjunct to traditional treatments for depressive symptoms. It is hypothesized that BoNT/A could influence neurochemical pathways to help alleviate depressive symptoms.

[METHODS] A systematic literature review was conducted focusing on Botulinum Neurotoxin Type A (BoNT/A) for depressive disorders. Primary studies published in English were included. Data were extracted on injection sites, dosage, adverse events, and outcomes. Statistical analysis included chi-squared tests and logistic regression to identify treatment predictors.

[RESULTS] Twelve studies were included, primarily targeting the glabellar region with BoNT/A injections. Approximately 71% of patients demonstrated reductions in depression symptoms. The chi-square test revealed a significant association between injection sites and depression improvement (p = 0.009). Higher doses of BoNT/A showed a marginally negative relationship with depression reduction (p = 0.098). Most adverse effects were mild, such as local site reactions and mild headaches, with no severe adverse events like suicidal ideation reported.

[CONCLUSIONS] This review describes the possible use of BoNT/A as an adjunct therapy for depressive symptoms, particularly when targeting facial muscles. Further research is needed to optimize dosage and explore the neurobiological mechanisms involved to improve therapeutic outcomes.

[LEVEL OF EVIDENCE IV] This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

추출된 의학 개체 (NER)

유형영어 표현한국어 / 풀이UMLS CUI출처등장
시술 botulinum toxin 보툴리눔독소 주사 dict 1
해부 glabellar scispacy 1
약물 BoNT/A → Botulinum Neurotoxin Type A C0006050
botulinum toxin type A
 scispacy 1
약물 [BACKGROUND] scispacy 1
약물 [CONCLUSIONS] scispacy 1
질환 Depressive scispacy 1
질환 Depression C0011570
Mental Depression
 scispacy 1
질환 depressive symptoms C0086132
Depressive Symptoms
 scispacy 1
질환 depressive disorders C0011581
Depressive disorder
 scispacy 1
질환 headaches C0018681
Headache
 scispacy 1
질환 ideation C0392348
ideation
 scispacy 1
질환 facial muscles scispacy 1
기타 Botulinum Neurotoxin Type A scispacy 1
기타 BoNT/A → Botulinum Neurotoxin Type A scispacy 1
기타 Neurotoxin Type scispacy 1
기타 patients scispacy 1

MeSH Terms

Humans; Botulinum Toxins, Type A; Depression; Treatment Outcome; Neuromuscular Agents; Female; Male

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외부 PMID 28건 (DB 미수집)

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