insight
← 뒤로

Central and Peripheral Sensitization in Temporomandibular Disorders: Proposed Mechanisms of Botulinum Toxin Therapy.

Toxins 2026 Vol.18(1)

Chaudhry BA, Robinson CL, Caronna E, Dodd-Glover F, Virk AS, Prieto Peres MF, O'Brien HL, Romero-Reyes M, Ashina S

PMC 전문 ↗ 원문 ↗ DOI ↗

관련 도메인

보툴리눔독소 주사 Botulinum Toxin Injection

Abstract

Temporomandibular disorders (TMDs) are common musculoskeletal chronic orofacial pain conditions involving peripheral and central sensitization within trigeminal nociceptive pathways, manifesting as mechanical allodynia and functional impairment. Botulinum toxin type A (BoNT-A) has been explored as a treatment targeting both muscle hyperactivity and nociceptive modulation. Preclinical and clinical evidence demonstrate that BoNT-A reduces peripheral neurotransmitter release, neurogenic inflammation, and central neuronal excitability, leading to attenuation of mechanical allodynia in TMD models and patients. Clinical trials show modest and variable analgesic effects, with patients displaying sensory sensitization appearing to respond more favorably, though methodological heterogeneity limits definitive conclusions. Safety concerns related to muscle weakening, changes in bone density, and structural changes underscore the need for standardized protocols optimizing dosing and monitoring, in addition to prospective studies. These findings suggest that BoNT-A may serve as an adjunctive, mechanism-based therapy within multimodal TMD management. Future research should focus on standardized sensory phenotyping and trial design to clarify BoNT-A's role in modulating central sensitization and improving patient outcomes.

추출된 의학 개체 (NER)

유형영어 표현한국어 / 풀이UMLS CUI출처등장
시술 botulinum toxin 보툴리눔독소 주사 dict 2
해부 Peripheral scispacy 1
해부 Temporomandibular scispacy 1
해부 trigeminal scispacy 1
해부 muscle scispacy 1
해부 peripheral neurotransmitter scispacy 1
해부 neuronal scispacy 1
해부 bone scispacy 1
약물 BoNT-A → Botulinum toxin type A scispacy 1
질환 Temporomandibular Disorders C0039494
Temporomandibular Joint Disorders
 scispacy 1
질환 TMDs → Temporomandibular disorders C0039494
Temporomandibular Joint Disorders
 scispacy 1
질환 musculoskeletal chronic orofacial pain scispacy 1
질환 allodynia C0458247
Allodynia
 scispacy 1
질환 muscle hyperactivity scispacy 1
질환 neurogenic inflammation C0600467
Neurogenic Inflammation
 scispacy 1
질환 TMD C0039496
Temporomandibular Joint Dysfunction Syndrome
 scispacy 1
기타 BoNT-A → Botulinum toxin type A scispacy 1
기타 patients scispacy 1
기타 patient scispacy 1

MeSH Terms

Temporomandibular Joint Disorders; Humans; Botulinum Toxins, Type A; Animals; Central Nervous System Sensitization; Neuromuscular Agents

📑 인용 관계

이 논문이 참조한 문헌 50

외부 PMID 30건 (DB 미수집)

🔗 함께 등장하는 도메인

이 논문이 속한 카테고리와 같은 논문에서 자주 함께 다뤄지는 카테고리들

필러 주입술 (21) 안검성형술 (14) 유방 (10) 안면거상술 (10) 지방흡입 (9) 코성형술 (8) 히알루론산 (7) 유방성형술 (6)

관련 논문