Persistent sexual side effects of finasteride: could they be permanent?
4/5 보강
TL;DR
In most men who developed persistent sexual side effects despite the discontinuation of finasteride, the sexual dysfunction continued for many months or years, which should be made aware of the potential adverse medication effects.
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
환자: male pattern hair loss reported persistent sexual dysfunction for ≥6 years, suggesting the possibility that the dysfunction may be permanent
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
Although several rat studies have shown detrimental changes to erectile function caused by 5 alpha reductase inhibitors, the persistent nature of these changes is an area of active research. Prescribers of finasteride and men contemplating its use should be made aware of the potential adverse medication effects.
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· 인용됨 28
📑 인용한 논문 (6) ▾
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- Comment on Current Investigations into the Postfinasteride Syndrome. International journal of trichology · 2024
연도별 인용 (2012–2026) · 합계 156
OpenAlex 토픽 ·
Sexual function and dysfunction studies
Hair Growth and Disorders
Hypothalamic control of reproductive hormones
In most men who developed persistent sexual side effects despite the discontinuation of finasteride, the sexual dysfunction continued for many months or years, which should be made aware of the potent
- 표본수 (n) 54
APA
Michael S. Irwig (2012). Persistent sexual side effects of finasteride: could they be permanent?. The journal of sexual medicine, 9(11), 2927-32. https://doi.org/10.1111/j.1743-6109.2012.02846.x
MLA
Michael S. Irwig. "Persistent sexual side effects of finasteride: could they be permanent?." The journal of sexual medicine, vol. 9, no. 11, 2012, pp. 2927-32.
PMID
22789024 ↗
Abstract 한글 요약
[INTRODUCTION] Finasteride has been associated with sexual side effects that may persist despite discontinuation of the medication. In a clinical series, 20% of subjects with male pattern hair loss reported persistent sexual dysfunction for ≥6 years, suggesting the possibility that the dysfunction may be permanent. These subjects also reported a wide range of symptoms including changes in cognition, ejaculate quality, and genital sensation. Other medications have been associated with irreversible neurological effects, such as phenothiazines with tardive dyskinesias.
[AIM] To prospectively study whether the persistent sexual side effects associated with finasteride resolve or endure over time.
[METHODS] Subjects (N = 54) with persistent sexual side effects associated with finasteride were reassessed after 9-16 months (mean 14 months). All subjects were otherwise healthy young men without any baseline sexual dysfunction, medical conditions, psychiatric conditions, or use of oral prescription medications prior to taking finasteride for male pattern hair loss.
[MAIN OUTCOME MEASURE] Scores from the Arizona Sexual Experience Scale (ASEX).
[RESULTS] The participation rate was 81%. At reassessment persistent sexual side effects continued to be present in 96% of subjects. According to the ASEX scores, 89% of subjects met the definition of sexual dysfunction. Neither the length of finasteride use nor the duration of the sexual side effects correlated to changes in scores of sexual dysfunction.
[CONCLUSION] In most men who developed persistent sexual side effects (≥3 months) despite the discontinuation of finasteride, the sexual dysfunction continued for many months or years. Although several rat studies have shown detrimental changes to erectile function caused by 5 alpha reductase inhibitors, the persistent nature of these changes is an area of active research. Prescribers of finasteride and men contemplating its use should be made aware of the potential adverse medication effects.
[AIM] To prospectively study whether the persistent sexual side effects associated with finasteride resolve or endure over time.
[METHODS] Subjects (N = 54) with persistent sexual side effects associated with finasteride were reassessed after 9-16 months (mean 14 months). All subjects were otherwise healthy young men without any baseline sexual dysfunction, medical conditions, psychiatric conditions, or use of oral prescription medications prior to taking finasteride for male pattern hair loss.
[MAIN OUTCOME MEASURE] Scores from the Arizona Sexual Experience Scale (ASEX).
[RESULTS] The participation rate was 81%. At reassessment persistent sexual side effects continued to be present in 96% of subjects. According to the ASEX scores, 89% of subjects met the definition of sexual dysfunction. Neither the length of finasteride use nor the duration of the sexual side effects correlated to changes in scores of sexual dysfunction.
[CONCLUSION] In most men who developed persistent sexual side effects (≥3 months) despite the discontinuation of finasteride, the sexual dysfunction continued for many months or years. Although several rat studies have shown detrimental changes to erectile function caused by 5 alpha reductase inhibitors, the persistent nature of these changes is an area of active research. Prescribers of finasteride and men contemplating its use should be made aware of the potential adverse medication effects.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
인용 관계
그래프 OA 노드: 7/8 (88%)
· 참조 0편 · 후속 7편
이 논문을 인용한 후속 연구 20
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같은 제1저자의 인용 많은 논문 (5)
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🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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- 양성 전립선 비대증 환자에서 finasteride의 효과. The Finasteride Study Group.
- 양성 전립선 비대증 남성에서 급성 요폐의 위험과 수술적 치료 필요성에 대한 finasteride의 효과. Finasteride Long-Term Efficacy and Safety Study Group.
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