The effects of finasteride on scalp skin and serum androgen levels in men with androgenetic alopecia.
4/5 보강
TL;DR
D doses of finasteride as low as 0.2 mg per day maximally decreased both scalp skin and serum DHT levels, which support the rationale used to conduct clinical trials in men with male pattern hair loss at doses of Finasteride between 0.
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
추출되지 않음
I · Intervention 중재 / 시술
scalp biopsies before and after receiving 0
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
[CONCLUSION] In this study, doses of finasteride as low as 0.2 mg per day maximally decreased both scalp skin and serum DHT levels. These data support the rationale used to conduct clinical trials in men with male pattern hair loss at doses of finasteride between 0.2 and 5 mg.
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연도별 인용 (2012–2025) · 합계 106
OpenAlex 토픽 ·
Hair Growth and Disorders
Ovarian function and disorders
Effects and risks of endocrine disrupting chemicals
Abstract 🌐 Abstract
[BACKGROUND] Data suggest that androgenetic alopecia is a process dependent on dihydrotestosterone (DHT) and type 2 5alpha-reductase. Finasteride is a type 2 5alpha-reductase inhibitor that has been shown to slow further hair loss and improve hair growth in men with androgenetic alopecia.
[OBJECTIVE] We attempted to determine the effect of finasteride on scalp skin and serum androgens.
[METHODS] Men with androgenetic alopecia (N = 249) underwent scalp biopsies before and after receiving 0.01, 0.05, 0.2, 1, or 5 mg daily of finasteride or placebo for 42 days.
[RESULTS] Scalp skin DHT levels declined significantly by 13.0% with placebo and by 14.9%, 61.6%, 56. 5%, 64.1%, and 69.4% with 0.01, 0.05, 0.2, 1, and 5 mg doses of finasteride, respectively. Serum DHT levels declined significantly (P <.001) by 49.5%, 68.6%, 71.4%, and 72.2% in the 0.05, 0.2, 1, and 5 mg finasteride treatment groups, respectively.
[CONCLUSION] In this study, doses of finasteride as low as 0.2 mg per day maximally decreased both scalp skin and serum DHT levels. These data support the rationale used to conduct clinical trials in men with male pattern hair loss at doses of finasteride between 0.2 and 5 mg.
[OBJECTIVE] We attempted to determine the effect of finasteride on scalp skin and serum androgens.
[METHODS] Men with androgenetic alopecia (N = 249) underwent scalp biopsies before and after receiving 0.01, 0.05, 0.2, 1, or 5 mg daily of finasteride or placebo for 42 days.
[RESULTS] Scalp skin DHT levels declined significantly by 13.0% with placebo and by 14.9%, 61.6%, 56. 5%, 64.1%, and 69.4% with 0.01, 0.05, 0.2, 1, and 5 mg doses of finasteride, respectively. Serum DHT levels declined significantly (P <.001) by 49.5%, 68.6%, 71.4%, and 72.2% in the 0.05, 0.2, 1, and 5 mg finasteride treatment groups, respectively.
[CONCLUSION] In this study, doses of finasteride as low as 0.2 mg per day maximally decreased both scalp skin and serum DHT levels. These data support the rationale used to conduct clinical trials in men with male pattern hair loss at doses of finasteride between 0.2 and 5 mg.
- 표본수 (n) 249
- p-value P <.001
D doses of finasteride as low as 0.2 mg per day maximally decreased both scalp skin and serum DHT levels, which support the rationale used to conduct clinical trials in men with male pattern hair loss
APA 7
Drake, L., Hordinsky, M., Fiedler, V., Swinehart, J., Unger, W. P., Cotterill, P. C., Thiboutot, D. M., Lowe, N., Jacobson, C., Whiting, D., Stieglitz, S., Kraus, S. J., Griffin, E. I., Weiss, D., Carrington, P., Gencheff, C., Cole, G. W., Pariser, D. M., Epstein, E. S., Tanaka, W., & ... (1999). The effects of finasteride on scalp skin and serum androgen levels in men with androgenetic alopecia.. Journal of the American Academy of Dermatology, 41(4), 550-4.
Vancouver
Drake L, Hordinsky M, Fiedler V, Swinehart J, Unger WP, Cotterill PC, et al. The effects of finasteride on scalp skin and serum androgen levels in men with androgenetic alopecia. Jour. Amer. Acad. Derm.. 1999;41(4):550-4.
AMA 11
Drake L, Hordinsky M, Fiedler V, Swinehart J, Unger WP, Cotterill PC, et al. The effects of finasteride on scalp skin and serum androgen levels in men with androgenetic alopecia. Jour. Amer. Acad. Derm.. 1999;41(4):550-4.
Chicago
Drake, L., Hordinsky, M., Fiedler, V., Swinehart, J., Unger, W. P., Cotterill, P. C., Thiboutot, D. M., Lowe, N., Jacobson, C., Whiting, D., and .... 1999. "The effects of finasteride on scalp skin and serum androgen levels in men with androgenetic alopecia." Journal of the American Academy of Dermatology 41 (4): 550-4.
MLA 9
Drake, L., et al. "The effects of finasteride on scalp skin and serum androgen levels in men with androgenetic alopecia." Journal of the American Academy of Dermatology, vol. 41, no. 4, 1999, pp. 550-4.
PMID
10495374 ↗
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
인용 관계
그래프 OA 노드: 8/8 (100%)
· 참조 0편 · 후속 8편
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- 양성 전립선 비대증 환자에서 finasteride의 효과. The Finasteride Study Group.
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- 양성 전립선 비대증 남성에서 finasteride의 효과.