Androgenetic alopecia: a review.
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TL;DR
A systematic review of the literature and candidate gene and genome-wide association studies have reported that single-nucleotide polymorphisms at different genomic loci are associated with androgenetic alopecia development.
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→ 이 논문이 인용한 논문 (6) ▾
- Effects of a novel finasteride 0.25% topical solution on scalp and serum dihydrotestostero… International journal of clinical pharmacology and therapeutics · 2016
- Topical minoxidil fortified with finasteride: An account of maintenance of hair density af… Indian dermatology online journal · 2015
- Oxidative stress-associated senescence in dermal papilla cells of men with androgenetic al… The Journal of investigative dermatology · 2015
- A novel finasteride 0.25% topical solution for androgenetic alopecia: pharmacokinetics and… International journal of clinical pharmacology and therapeutics · 2014
- Efficacy and safety of 3% minoxidil versus combined 3% minoxidil / 0.1% finasteride in mal… Journal of the Medical Association of Thailand = Chotmaihet thangphaet · 2012
- Adverse side effects of 5α-reductase inhibitors therapy: persistent diminished libido and … The journal of sexual medicine · 2011
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연도별 인용 (2017–2026) · 합계 500
OpenAlex 토픽 ·
Hair Growth and Disorders
Facial Rejuvenation and Surgery Techniques
Cancer and Skin Lesions
🇰🇷 한글 요약 🌐 Abstract
【연구 목적】
남성형 탈모(male pattern baldness)로 알려진 안드로겐성 탈모(androgenetic alopecia, AGA)의 병태생리와 분자기전에 관한 최신 연구 동향을 정리하기 위한 문헌 고찰.
【방법】
PubMed 데이터베이스를 활용하여 1916년부터 2016년까지 발표된 관련 문헌을 체계적으로 선별·검토함.
【주요 결과】
AGA는 내분비 인자와 유전적 소인의 상호작용으로 발생하며, 안드로겐 의존성 부위의 유전적으로 감수성 있는 모낭 상피세포에 안드로겐이 작용하여 점진적인 모낭 소형화(follicular miniaturization)가 진행됨. 다유전자성 질환(polygenic condition)으로 X 염색체상의 AR/EDA2R 유전자좌와 20번 염색체 20p11 유전자좌가 주요 유전적 위험 인자로 확인되었으며, 후보 유전자 연구 및 전장유전체연관분석(GWAS)을 통해 다양한 단일염기다형성(SNP)이 발병과 연관됨이 보고됨.
【임상적 시사점 (성형외과 의사 관점)】
AGA는 단일 원인이 아닌 호르몬-유전 복합 질환이므로, 모발이식(hair transplantation) 시술 전 가족력 청취와 안드로겐 의존성 부위 평가가 필수이며, 환자에게 진행성 질환임을 설명하고 피나스테리드(finasteride)·미녹시딜(minoxidil) 등 내과적 병행치료의 필요성을 안내해야 함. 향후 유전자 검사 기반의 개인 맞춤형 위험 예측 및 치료 반응 예측이 임상에 도입될 가능성이 있어 관련 지식을 지속적으로 업데이트할 필요가 있음.
[PURPOSE] Androgenetic alopecia, commonly known as male pattern baldness, is the most common type of progressive hair loss disorder in men. The aim of this paper is to review recent advances in understanding the pathophysiology and molecular mechanism of androgenetic alopecia.
[METHODS] Using the PubMed database, we conducted a systematic review of the literature, selecting studies published from 1916 to 2016.
[RESULTS] The occurrence and development of androgenetic alopecia depends on the interaction of endocrine factors and genetic predisposition. Androgenetic alopecia is characterized by progressive hair follicular miniaturization, caused by the actions of androgens on the epithelial cells of genetically susceptible hair follicles in androgen-dependent areas. Although the exact pathogenesis of androgenetic alopecia remains to be clarified, research has shown that it is a polygenetic condition. Numerous studies have unequivocally identified two major genetic risk loci for androgenetic alopecia, on the X-chromosome AR⁄EDA2R locus and the chromosome 20p11 locus.
[CONCLUSIONS] Candidate gene and genome-wide association studies have reported that single-nucleotide polymorphisms at different genomic loci are associated with androgenetic alopecia development. A number of genes determine the predisposition for androgenetic alopecia in a polygenic fashion. However, further studies are needed before the specific genetic factors of this polygenic condition can be fully explained.
[METHODS] Using the PubMed database, we conducted a systematic review of the literature, selecting studies published from 1916 to 2016.
[RESULTS] The occurrence and development of androgenetic alopecia depends on the interaction of endocrine factors and genetic predisposition. Androgenetic alopecia is characterized by progressive hair follicular miniaturization, caused by the actions of androgens on the epithelial cells of genetically susceptible hair follicles in androgen-dependent areas. Although the exact pathogenesis of androgenetic alopecia remains to be clarified, research has shown that it is a polygenetic condition. Numerous studies have unequivocally identified two major genetic risk loci for androgenetic alopecia, on the X-chromosome AR⁄EDA2R locus and the chromosome 20p11 locus.
[CONCLUSIONS] Candidate gene and genome-wide association studies have reported that single-nucleotide polymorphisms at different genomic loci are associated with androgenetic alopecia development. A number of genes determine the predisposition for androgenetic alopecia in a polygenic fashion. However, further studies are needed before the specific genetic factors of this polygenic condition can be fully explained.
- 연구 설계 systematic review
【연구 목적】 남성형 탈모(male pattern baldness)로 알려진 안드로겐성 탈모(androgenetic alopecia, AGA)의 병태생리와 분자기전에 관한 최신 연구 동향을 정리하기 위한 문헌 고찰.
APA 7
Lolli, F., Pallotti, F., Rossi, A., Fortuna, M. C., Caro, G., Lenzi, A., Sansone, A., & Lombardo, F. (2017). Androgenetic alopecia: A review.. Endocrine, 57(1), 9-17. https://doi.org/10.1007/s12020-017-1280-y
Vancouver
Lolli F, Pallotti F, Rossi A, Fortuna MC, Caro G, Lenzi A, et al. Androgenetic alopecia: a review. Endocrine. 2017;57(1):9-17. doi:10.1007/s12020-017-1280-y
AMA 11
Lolli F, Pallotti F, Rossi A, Fortuna MC, Caro G, Lenzi A, et al. Androgenetic alopecia: a review. Endocrine. 2017;57(1):9-17. doi:10.1007/s12020-017-1280-y
Chicago
Lolli, F., Pallotti, F., Rossi, A., Fortuna, M. C., Caro, G., Lenzi, A., Sansone, A., and Lombardo, F.. 2017. "Androgenetic alopecia: a review." Endocrine 57 (1): 9-17. https://doi.org/10.1007/s12020-017-1280-y
MLA 9
Lolli, F., et al. "Androgenetic alopecia: a review." Endocrine, vol. 57, no. 1, 2017, pp. 9-17. doi:10.1007/s12020-017-1280-y.
PMID
28349362 ↗
추출된 의학 개체 (NER)
전체 NER 표 보기
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 질환 | androgenetic alopecia
|
안드로겐성 탈모 | dict | 9 | |
| 질환 | androgenetic alopecia
|
안드로겐성 탈모 | dict | 9 |
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
인용 관계
그래프 OA 노드: 9/16 (56%)
· 참조 1편 · 후속 8편
이 논문이 참조한 문헌 50
- Oxidative stress-associated senescence in dermal papilla cells of men with androgenetic alopecia.
- Persistent sexual side effects of finasteride for male pattern hair loss.
- Androgenetic alopecia.
- Adverse side effects of 5α-reductase inhibitors therapy: persistent diminished libido and erectile d…
- The effects of finasteride on scalp skin and serum androgen levels in men with androgenetic alopecia…
- Finasteride, 1 mg daily administration on male androgenetic alopecia in different age groups: 10-yea…
- A novel finasteride 0.25% topical solution for androgenetic alopecia: pharmacokinetics and effects o…
- Effects of a novel finasteride 0.25% topical solution on scalp and serum dihydrotestosterone in heal…
- Topical minoxidil fortified with finasteride: An account of maintenance of hair density after replac…
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- Genetic analysis of male pattern baldness and the 5alpha-reductase genes.
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- Comparative efficacy of various treatment regimens for androgenetic alopecia in men.
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- Androgenetic alopecia and current methods of treatment.
- Efficacy of 5% minoxidil versus combined 5% minoxidil and 0.01% tretinoin for male pattern hair loss…
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외부 PMID 30건 (DB 미수집)
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이 논문을 인용한 후속 연구 20
- Treatment options for androgenetic alopecia: Efficacy, side effects, compliance, financial considera…
- A Systematic Review of Topical Finasteride in the Treatment of Androgenetic Alopecia in Men and Wome…
- Treatment of Androgenetic Alopecia: Current Guidance and Unmet Needs.
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- Topical Treatment for Scarring and Non-Scarring Alopecia: An Overview of the Current Evidence.
- Comorbidities in Androgenetic Alopecia: A Comprehensive Review.
- Treatment of Androgenetic Alopecia Using PRP to Target Dysregulated Mechanisms and Pathways.
- A combination therapy for androgenic alopecia based on quercetin and zinc/copper dual-doped mesoporo…
- Effectiveness and Safety of Botulinum Toxin Type A in the Treatment of Androgenetic Alopecia.
- Protective Role of Nutritional Plants Containing Flavonoids in Hair Follicle Disruption: A Review.
- Adipose-Derived Stem Cell Exosomes Antagonize the Inhibitory Effect of Dihydrotestosterone on Hair F…
- Microneedling and Its Use in Hair Loss Disorders: A Systematic Review.
- Efficacy of Asymmetric siRNA Targeting Androgen Receptors for the Treatment of Androgenetic Alopecia…
- Androgenetic Alopecia: Relationship to Anthropometric Indices, Blood Pressure and Life-Style Habits.
- Status of research on the development and regeneration of hair follicles.
- Androgenic alopecia is associated with higher dietary inflammatory index and lower antioxidant index…
- Phytochemical Constitution, Anti-Inflammation, Anti-Androgen, and Hair Growth-Promoting Potential of…
- Prevalence of Low Serum Vitamin D Levels in Patients Presenting With Androgenetic Alopecia: A Review…
- Platelet-rich Plasma for Androgenetic Alopecia Treatment: A Randomized Placebo-controlled Pilot Stud…
- Injections of platelet-rich plasma prepared by automatic blood cell separator combined with topical …
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
📖 비슷한 OA 논문 — 같은 카테고리, 무료 전문 가능
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