Oxidative stress-associated senescence in dermal papilla cells of men with androgenetic alopecia.
5/5 보강
TL;DR
In vitro findings suggest that there may be a role for oxidative stress in the pathogenesis of AGA both in relation to cell senescence and migration but also secretion of known hair follicle inhibitory factors.
📑 코퍼스 인용 관계
· 인용됨 70 · 인용함 55
→ 이 논문이 인용한 논문 (3) ▾
- Dickkopf 1 promotes regression of hair follicles. The Journal of investigative dermatology · 2012
- Induction of hair growth by implantation of cultured dermal papilla cells. Nature · 1984
- Male pattern baldness: classification and incidence. Southern medical journal · 1975
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연도별 인용 (2013–2026) · 합계 223
OpenAlex 토픽 ·
Skin Protection and Aging
Hair Growth and Disorders
Telomeres, Telomerase, and Senescence
🇰🇷 한글 요약 🌐 Abstract
【연구 목적】
남성형 탈모(androgenetic alopecia, AGA) 환자의 모유두세포(dermal papilla cells, DPCs)에서 관찰되는 조기 세포노화 현상이 산화 스트레스(oxidative stress)와 어떤 연관이 있는지, 그리고 이것이 탈모 병인에 기여하는지를 규명하고자 함.
【방법】
동일 환자의 탈모 부위(전두부) 두피와 비탈모 부위(후두부) 두피에서 채취한 모유두세포를 대기 중 산소 농도(21%)와 생리학적 산소 농도(2%) 환경에서 각각 배양하여 형태, 이동성, 활성산소(ROS), 노화 표지자(p16INK4a, pRB, SA-β-Gal), 항산화 효소(catalase, glutathione), 모발 성장 억제 인자(TGF-β1, TGF-β2) 분비를 비교 분석함.
【주요 결과】
21% 산소 환경에서 탈모 부위 DPCs는 후두부 세포 대비 편평한 형태, 이동성 저하, ROS 및 노화 표지자 증가를 보였고, H2O2 자극 시 TGF-β1·β2 분비가 유의하게 증가함. 탈모 부위 DPCs는 catalase와 총 glutathione 수치는 더 높았으나, 산화 스트레스 대응 능력은 오히려 떨어지는 역설적 양상을 보임.
【임상적 시사점 (성형외과 의사 관점)】
모발이식(hair transplantation) 시 후두부 공여부 모낭이 탈모 부위 모낭보다 산화 스트레스 저항성이 우수하다는 분자생물학적 근거를 제공하여 donor dominance 이론을 뒷받침함. AGA 치료 및 모발이식 전후 보조요법으로 항산화제(국소 또는 경구) 및 TGF-β 억제 전략의 병용을 고려해볼 수 있으며, PRP·엑소좀 시술 시 산화 스트레스 감소 효과를 환자 상담에 활용할 수 있음.
Dermal papilla cells (DPCs) taken from male androgenetic alopecia (AGA) patients undergo premature senescence in vitro in association with the expression of p16(INK4a), suggesting that DPCs from balding scalp are more sensitive to environmental stress than nonbalding cells. As one of the major triggers of senescence in vitro stems from the cell "culture shock" owing to oxidative stress, we have further investigated the effects of oxidative stress on balding and occipital scalp DPCs. Patient-matched DPCs from balding and occipital scalp were cultured at atmospheric (21%) or physiologically normal (2%) O2. At 21% O2, DPCs showed flattened morphology and a significant reduction in mobility, population doubling, increased levels of reactive oxygen species and senescence-associated β-Gal activity, and increased expression of p16(INK4a) and pRB. Balding DPCs secreted higher levels of the negative hair growth regulators transforming growth factor beta 1 and 2 in response to H2O2 but not cell culture-associated oxidative stress. Balding DPCs had higher levels of catalase and total glutathione but appear to be less able to handle oxidative stress compared with occipital DPCs. These in vitro findings suggest that there may be a role for oxidative stress in the pathogenesis of AGA both in relation to cell senescence and migration but also secretion of known hair follicle inhibitory factors.
【연구 목적】 남성형 탈모(androgenetic alopecia, AGA) 환자의 모유두세포(dermal papilla cells, DPCs)에서 관찰되는 조기 세포노화 현상이 산화 스트레스(oxidative stress)와 어떤 연관이 있는지, 그리고 이것이 탈모 병인에 기여하는지를 규명하고자 함.
APA 7
Upton, J. H., Hannen, R. F., Bahta, A. W., Farjo, N., Farjo, B., & Philpott, M. P. (2015). Oxidative stress-associated senescence in dermal papilla cells of men with androgenetic alopecia.. The Journal of investigative dermatology, 135(5), 1244-1252. https://doi.org/10.1038/jid.2015.28
Vancouver
Upton JH, Hannen RF, Bahta AW, Farjo N, Farjo B, Philpott MP. Oxidative stress-associated senescence in dermal papilla cells of men with androgenetic alopecia. Jour. inve. derm.. 2015;135(5):1244-1252. doi:10.1038/jid.2015.28
AMA 11
Upton JH, Hannen RF, Bahta AW, Farjo N, Farjo B, Philpott MP. Oxidative stress-associated senescence in dermal papilla cells of men with androgenetic alopecia. Jour. inve. derm.. 2015;135(5):1244-1252. doi:10.1038/jid.2015.28
Chicago
Upton, J. H., Hannen, R. F., Bahta, A. W., Farjo, N., Farjo, B., and Philpott, M. P.. 2015. "Oxidative stress-associated senescence in dermal papilla cells of men with androgenetic alopecia." The Journal of investigative dermatology 135 (5): 1244-1252. https://doi.org/10.1038/jid.2015.28
MLA 9
Upton, J. H., et al. "Oxidative stress-associated senescence in dermal papilla cells of men with androgenetic alopecia." The Journal of investigative dermatology, vol. 135, no. 5, 2015, pp. 1244-1252. doi:10.1038/jid.2015.28.
PMID
25647436 ↗
추출된 의학 개체 (NER)
전체 NER 표 보기
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 해부 | scalp
|
두피 | dict | 3 | |
| 질환 | androgenetic alopecia
|
안드로겐성 탈모 | dict | 2 | |
| 해부 | hair follicle
|
모낭 | dict | 1 |
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
인용 관계
그래프 OA 노드: 9/11 (82%)
· 참조 1편 · 후속 8편
이 논문이 참조한 문헌 33
- Male pattern baldness: classification and incidence.
- Induction of hair growth by implantation of cultured dermal papilla cells.
- Dickkopf 1 promotes regression of hair follicles.
외부 PMID 30건 (DB 미수집)
- PMID 10744631 ↗
- PMID 10911952 ↗
- PMID 11060295 ↗
- PMID 11100905 ↗
- PMID 11170294 ↗
- PMID 11231320 ↗
- PMID 11358493 ↗
- PMID 11779835 ↗
- PMID 12397096 ↗
- PMID 12673073 ↗
- PMID 12787113 ↗
- PMID 14657623 ↗
- PMID 14674898 ↗
- PMID 14675213 ↗
- PMID 14675219 ↗
- PMID 14819896 ↗
- PMID 15194142 ↗
- PMID 15620660 ↗
- PMID 15671065 ↗
- PMID 15824040 ↗
- PMID 15936251 ↗
- PMID 16004951 ↗
- PMID 1613448 ↗
- PMID 16331674 ↗
- PMID 17037979 ↗
- PMID 1711785 ↗
- PMID 17379547 ↗
- PMID 17657240 ↗
- PMID 17890327 ↗
- PMID 17901404 ↗
이 논문을 인용한 후속 연구 20
- Androgenetic alopecia: a review.
- Tissue engineering of human hair follicles using a biomimetic developmental approach.
- Diet and hair loss: effects of nutrient deficiency and supplement use.
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- Rescuing key native traits in cultured dermal papilla cells for human hair regeneration.
- Scalp Condition Impacts Hair Growth and Retention via Oxidative Stress.
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🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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