Dickkopf 1 promotes regression of hair follicles.
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TL;DR
The data strongly suggest that DKK-1 is involved in anagen-to-catagen transition in the hair cycle by regulating the activity of follicular keratinocytes.
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연도별 인용 (2012–2026) · 합계 152
OpenAlex 토픽 ·
Hair Growth and Disorders
Wnt/β-catenin signaling in development and cancer
Skin and Cellular Biology Research
The data strongly suggest that DKK-1 is involved in anagen-to-catagen transition in the hair cycle by regulating the activity of follicular keratinocytes.
APA
Mi Hee Kwack, Moon Kim, et al. (2012). Dickkopf 1 promotes regression of hair follicles.. The Journal of investigative dermatology, 132(6), 1554-60. https://doi.org/10.1038/jid.2012.24
MLA
Mi Hee Kwack, et al.. "Dickkopf 1 promotes regression of hair follicles.." The Journal of investigative dermatology, vol. 132, no. 6, 2012, pp. 1554-60.
PMID
22358062 ↗
Abstract 한글 요약
Recently, we suggested that Dickkopf 1 (DKK-1) is a pathogenic mediator involved in male pattern baldness. As premature catagen onset is a key characteristic of male pattern baldness, in this study, we evaluated whether DKK-1 has a role as a catagen inducer in hair cycling. Herein, we report that recombinant human DKK-1 (rhDKK-1) injection into the hypodermis of mice during anagen caused premature onset of catagen, whereas neutralizing DKK-1 antibody delayed anagen-to-catagen transition in mice. Moreover, treatment with rhDKK-1 led to a decrease in final hair follicle length, whereas DKK-1 antibody led to an increase compared with control animals. In addition, DKK-1 and DKK-1 messenger RNA expression is most upregulated in follicular keratinocytes of late anagen in depilation-induced hair cycle progression. Moreover, we observed that rhDKK-1 blocks canonical Wnt-mediated activation of β-catenin signaling and induces the proapoptotic protein Bax, resulting in apoptosis in outer root sheath keratinocytes. Taken together, our data strongly suggest that DKK-1 is involved in anagen-to-catagen transition in the hair cycle by regulating the activity of follicular keratinocytes.
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그래프 OA 노드: 8/8 (100%)
· 참조 0편 · 후속 8편
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같은 제1저자의 인용 많은 논문 (5)
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