Exosomes derived from human dermal papilla cells promote hair growth in cultured human hair follicles and augment the hair-inductive capacity of cultured dermal papilla spheres.
4/5 보강
TL;DR
The data strongly suggest that Exos derived from DP cells promote hair growth and hair regeneration by regulating the activity of follicular dermal and epidermal cells; accordingly, these findings have implications for the development of therapeutic strategies for hair loss.
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📑 인용한 논문 (6) ▾
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연도별 인용 (2017–2026) · 합계 126
OpenAlex 토픽 ·
Hair Growth and Disorders
Skin and Cellular Biology Research
Dermatologic Treatments and Research
The data strongly suggest that Exos derived from DP cells promote hair growth and hair regeneration by regulating the activity of follicular dermal and epidermal cells; accordingly, these findings hav
APA
Mi Hee Kwack, Chang Hoon Seo, et al. (2019). Exosomes derived from human dermal papilla cells promote hair growth in cultured human hair follicles and augment the hair-inductive capacity of cultured dermal papilla spheres.. Experimental dermatology, 28(7), 854-857. https://doi.org/10.1111/exd.13927
MLA
Mi Hee Kwack, et al.. "Exosomes derived from human dermal papilla cells promote hair growth in cultured human hair follicles and augment the hair-inductive capacity of cultured dermal papilla spheres.." Experimental dermatology, vol. 28, no. 7, 2019, pp. 854-857.
PMID
30924959 ↗
Abstract 한글 요약
Dermal papillae (DP) play key roles in hair growth and regeneration by regulating follicular cell activity. Owing to the established roles of exosomes (Exos) in the regulation of cell functions, we investigated whether DP-derived Exos, especially those from three-dimensional (3D)-cultured DP cells, affect hair growth, cycling and regeneration. Exos derived from 3D DP (3D DP-Exos) promoted the proliferation of DP cells and outer root sheath (ORS) cells and increased the expression of growth factors (IGF-1, KGF and HGF) in DP cells. 3D DP-Exo treatment also increased hair shaft elongation in cultured human hair follicles. In addition, local injections of 3D DP-Exos induced anagen from telogen and also prolonged anagen in mice. Moreover, Exo treatment in human DP spheres augmented hair follicle neogenesis when the DP spheres were implanted with mouse epidermal cells. Similar results were obtained using Exos derived from 2D-cultured DP cells (2D DP-Exo). Collectively, our data strongly suggest that Exos derived from DP cells promote hair growth and hair regeneration by regulating the activity of follicular dermal and epidermal cells; accordingly, these findings have implications for the development of therapeutic strategies for hair loss.
추출된 의학 개체 (NER)
전체 NER 표 보기
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 해부 | hair follicle
|
모낭 | dict | 1 | |
| 해부 | hair follicle
|
모낭 | dict | 1 | |
| 해부 | hair follicle
|
모낭 | dict | 1 |
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Animals
- Cell Culture Techniques
- Cell Proliferation
- Cells
- Cultured
- Dermis
- Exosomes
- Female
- Fibroblasts
- Hair
- Hair Follicle
- Humans
- Intercellular Signaling Peptides and Proteins
- Male
- Mice
- Inbred C57BL
- Nude
- Microscopy
- Phase-Contrast
- dermal papilla
- exosome
- hair growth
- hair reconstitution
- three-dimensional (3D) culture
인용 관계
그래프 OA 노드: 8/8 (100%)
· 참조 0편 · 후속 8편
이 논문을 인용한 후속 연구 20
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