Finasteride in the treatment of men with androgenetic alopecia. Finasteride Male Pattern Hair Loss Study Group.
4/5 보강
TL;DR
In men with male pattern hair loss, finasteride 1 mg/d slowed the progression of hair loss and increased hair growth in clinical trials over 2 years.
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
추출되지 않음
I · Intervention 중재 / 시술
oral finasteride 1 mg/d or placebo, and 1215 men continued in blinded extension studies for a second year
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
Adverse effects were minimal. [CONCLUSION] In men with male pattern hair loss, finasteride 1 mg/d slowed the progression of hair loss and increased hair growth in clinical trials over 2 years.
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연도별 인용 (2012–2026) · 합계 446
OpenAlex 토픽 ·
Hair Growth and Disorders
Facial Rejuvenation and Surgery Techniques
Sexual Differentiation and Disorders
Abstract 🌐 Abstract
[BACKGROUND] Androgenetic alopecia (male pattern hair loss) is caused by androgen-dependent miniaturization of scalp hair follicles, with scalp dihydrotestosterone (DHT) implicated as a contributing cause. Finasteride, an inhibitor of type II 5alpha-reductase, decreases serum and scalp DHT by inhibiting conversion of testosterone to DHT.
[OBJECTIVE] Our purpose was to determine whether finasteride treatment leads to clinical improvement in men with male pattern hair loss.
[METHODS] In two 1-year trials, 1553 men (18 to 41 years of age) with male pattern hair loss received oral finasteride 1 mg/d or placebo, and 1215 men continued in blinded extension studies for a second year. Efficacy was evaluated by scalp hair counts, patient and investigator assessments, and review of photographs by an expert panel.
[RESULTS] Finasteride treatment improved scalp hair by all evaluation techniques at 1 and 2 years (P < .001 vs placebo, all comparisons). Clinically significant increases in hair count (baseline = 876 hairs), measured in a 1-inch diameter circular area (5.1 cm2) of balding vertex scalp, were observed with finasteride treatment (107 and 138 hairs vs placebo at 1 and 2 years, respectively; P < .001). Treatment with placebo resulted in progressive hair loss. Patients' self-assessment demonstrated that finasteride treatment slowed hair loss, increased hair growth, and improved appearance of hair. These improvements were corroborated by investigator assessments and assessments of photographs. Adverse effects were minimal.
[CONCLUSION] In men with male pattern hair loss, finasteride 1 mg/d slowed the progression of hair loss and increased hair growth in clinical trials over 2 years.
[OBJECTIVE] Our purpose was to determine whether finasteride treatment leads to clinical improvement in men with male pattern hair loss.
[METHODS] In two 1-year trials, 1553 men (18 to 41 years of age) with male pattern hair loss received oral finasteride 1 mg/d or placebo, and 1215 men continued in blinded extension studies for a second year. Efficacy was evaluated by scalp hair counts, patient and investigator assessments, and review of photographs by an expert panel.
[RESULTS] Finasteride treatment improved scalp hair by all evaluation techniques at 1 and 2 years (P < .001 vs placebo, all comparisons). Clinically significant increases in hair count (baseline = 876 hairs), measured in a 1-inch diameter circular area (5.1 cm2) of balding vertex scalp, were observed with finasteride treatment (107 and 138 hairs vs placebo at 1 and 2 years, respectively; P < .001). Treatment with placebo resulted in progressive hair loss. Patients' self-assessment demonstrated that finasteride treatment slowed hair loss, increased hair growth, and improved appearance of hair. These improvements were corroborated by investigator assessments and assessments of photographs. Adverse effects were minimal.
[CONCLUSION] In men with male pattern hair loss, finasteride 1 mg/d slowed the progression of hair loss and increased hair growth in clinical trials over 2 years.
- p-value P < .001
In men with male pattern hair loss, finasteride 1 mg/d slowed the progression of hair loss and increased hair growth in clinical trials over 2 years.
APA 7
Kaufman, K. D., Olsen, E. A., Whiting, D., Savin, R., DeVillez, R., Bergfeld, W., Price, V. H., D, V. N., Roberts, J. L., Hordinsky, M., Shapiro, J., Binkowitz, B., & Gormley, G. J. (1998). Finasteride in the treatment of men with androgenetic alopecia. Finasteride male pattern hair loss study group.. Journal of the American Academy of Dermatology, 39(4 Pt 1), 578-89. https://doi.org/10.1016/s0190-9622(98)70007-6
Vancouver
Kaufman KD, Olsen EA, Whiting D, Savin R, DeVillez R, Bergfeld W, et al. Finasteride in the treatment of men with androgenetic alopecia. Finasteride Male Pattern Hair Loss Study Group. Jour. Amer. Acad. Derm.. 1998;39(4 Pt 1):578-89. doi:10.1016/s0190-9622(98)70007-6
AMA 11
Kaufman KD, Olsen EA, Whiting D, Savin R, DeVillez R, Bergfeld W, et al. Finasteride in the treatment of men with androgenetic alopecia. Finasteride Male Pattern Hair Loss Study Group. Jour. Amer. Acad. Derm.. 1998;39(4 Pt 1):578-89. doi:10.1016/s0190-9622(98)70007-6
Chicago
Kaufman, K. D., Olsen, E. A., Whiting, D., Savin, R., DeVillez, R., Bergfeld, W., Price, V. H., D, V. N., Roberts, J. L., Hordinsky, M., and .... 1998. "Finasteride in the treatment of men with androgenetic alopecia. Finasteride Male Pattern Hair Loss Study Group." Journal of the American Academy of Dermatology 39 (4 Pt 1): 578-89. https://doi.org/10.1016/s0190-9622(98)70007-6
MLA 9
Kaufman, K. D., et al. "Finasteride in the treatment of men with androgenetic alopecia. Finasteride Male Pattern Hair Loss Study Group." Journal of the American Academy of Dermatology, vol. 39, no. 4 Pt 1, 1998, pp. 578-89. doi:10.1016/s0190-9622(98)70007-6.
PMID
9777765 ↗
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
인용 관계
그래프 OA 노드: 7/8 (88%)
· 참조 0편 · 후속 7편
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