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To explore the influence and mechanism of extracellular vesicles (EVs) derived from human dermal papilla cells (hDPCs), i. e. hDPC-EVs on skin fibrosis in mice. This study was an experimental research. One hundred discarded hair follicle u…

[BACKGROUND] Hair restoration surgery (HRS) is a very promising and sought after aesthetic procedure with very few complications. Complications may occur in the donor or the recipient area, and it may be due to surgical or idiopathic causes…

[BACKGROUND] Keloids and hypertrophic scars are characterized by pathologically excessive dermal fibrosis and aberrant wound healing. These pathological scars are characterized by continuous and histologically localized inflammation of the …

Treatment of keloids and hypertrophic scars poses a significant challenge. Several treatments are beneficial, including surgery, technologies such as lasers, medication injections (eg, triamcinolone and antineoplastic drugs), cryotherapy, a…

Botulinum toxin A (BTXA) is a safe and widely used neurotoxic protein in cosmetic procedures and medical applications. This investigation focuses on the function of BTXA on macrophage phenotype during hypertrophic scar (HS) formation and th…

Hypertrophic scar (HS) is a fibrous proliferative disorder that occurs in the dermis after skin injury. Studies have confirmed that Botulinum toxin type A (BTA) is effective in scar prevention and treatment. However, the specific mechanism …

[OBJECTIVE] Maxillofacial-neck hyperplastic scars have long been a persistent concern among individuals in both Western and Eastern countries. These scars exhibit rapid growth within 3-6 months following wound healing, subsequently receding…

Hypertrophic scars arise from aberrant wound healing and can lead to functional and aesthetic impairments. One of the common interventions for treating hypertrophic scars is fractional carbon dioxide (CO2) laser, which employs narrow laser …

[OBJECTIVE] Cleft lip repair (CLR) can be complicated by hypertrophic scar or keloid. Botulinum toxin type A (BTA) may improve postoperative scarring by reducing muscle tension and cytokine activity at the scar site. This systematic review …

[OBJECTIVE] To validate the feasibility of ultrasound in assessing the curative effect of botulinum toxin type A (BTXA) in treating hypertrophic scar (HS). [METHODS] Eight healthy New Zealand long-eared rabbits were utilized in the study. …

Hypertrophic scars can have significant and far-reaching effects on patients that range from itching to creating difficulty with mobility, all of which can negatively impact the individual's quality of life. A recent study showed that many …

[BACKGROUND] Hypertrophic scar (HS) is a common disease in plastic and cosmetic surgery, with limited treatment options, and is a challenge for clinicians. [OBJECTIVES] This study aimed to evaluate the efficacy of fractional carbon dioxide…

[BACKGROUND] Consequently, the management of post burn hypertrophic scars and keloid in children are a great challenge for the physicians, parents, and children themselves. [PURPOSE OF THE STUDY] To assess the efficacy and safety of treati…

[BACKGROUND] Hypertrophic scar (HS), as a disappointing result of wound healing, adversely affects the patient, both physically and psychologically. Botulinum toxin type A (BTXA) has been revealed to prevent and improve HS. We conducted thi…

[INTRODUCTION] Keloids are hypertrophic scars that commonly arise in the ear region. The authors' objectives were to (1) evaluate effectiveness of surgical shave excision followed by intralesional triamcinolone acetonide and onabotulinumtox…

[BACKGROUND] Hypertrophic scar formation may be related to cutaneous neurogenic inflammation (CNI) through the substance P-neurokinin 1 receptor (SP-NK1R) signaling pathway. As a widely used drug in aesthetic clinical work, botulinum toxin …

Keloid is a type of unusually raised scar. Botulinum toxin A (BTX-A) has a great application potential in keloids treatment. Here, we investigated the functional role of BTX-A in keloids. We separated keloid tissues and normal skin tissues …

[BACKGROUND] Both keloid and hypertrophic scars are common benign skin lesions manifested by hyperplasia of fibroblasts. Clinically, this will not only have physiological effects on patients, but also cause psychological damage. However, th…

[BACKGROUND] The effect of Botulinum toxin type A (BTX-A) in treating or preventing a hypertrophic scar (HS) had been reported in clinical studies. However, the dose-effect relationship remains unclear. [OBJECTIVE] To study the dose-effect…