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Hydrostatic pressure mechanism and surgical efficacy of Tarlov cysts.
[BACKGROUND] Tarlov cysts (TCs) are commonly found sacral perineural cysts. Symptomatic TCs are rare, and there is no consensus on optimal treatment. The pathophysiological mechanism of TCs remains unclear. The aim of this study is to inves…
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Feasibility and efficacy of radical tumour resection with primary vascularized free flap reconstruction for advanced oral cancer in patients with thrombocytopenia: a prospective study.
Thrombocytopenia is caused by various diseases and increases the risk of bleeding. Radical surgery with vascularized free-flap reconstruction is the preferred approach for advanced oral cancer; however, its safety and feasibility in patient…
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Post-sleeve gastrectomy weight loss: Role of botulinum toxin and semaglutide injections.
[BACKGROUND AND STUDY AIMS] Comparison of the therapeutic effects of endoscopic botulinum toxin (BTX) injection and semaglutide (SME) injection in treatment of patients with obesity and weight regain after laparoscopic sleeve gastrectomy (L…
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A comparative study of radiation tolerance between dECM hydrogel-adipose composite biomaterials and traditional breast implants.
Postmastectomy breast reconstruction is limited by radiotherapy-induced tissue damage, as silicone implants are prone to capsular contracture, and autologous adipose grafts are limited by resorption and necrosis. In this study, two biomater…
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Random forest algorithm for predicting postoperative hypotension in oral cancer resection and free flap reconstruction surgery.
This study aimed to investigate the risk factors for low postoperative blood pressure and construct a machine learning (ML) model based on these features for real-time prediction in patients with oral cancer following reconstruction surgery…
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The effect of preoperative oral carbohydrate on the perioperative period of fibula free flap surgery in patients with oral cancer: a retrospective study.
[OBJECTIVE] This study examines the effects of preoperative oral carbohydrates on the perioperative period of Fibula Free Flap surgery in oral cancer patients, aiming to enhance postoperative recovery. [METHODS] The study involved 89 patie…
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Superficial Temporal Artery Pseudoaneurysm Following Facial Thread-Lift: A Rare Complication.
Thread lifting has become widely adopted worldwide as a nonsurgical facial rejuvenation technique due to its simplicity and short recovery period. However, despite its generally favorable safety profile, various complications may occur, wit…
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Effect of Sub-Eyebrow Small Incision Dissection of the Corrugator Supercilii Muscle Combined with Autologous Block Fat Transplantation for the Treatment of Severe Frown Lines.
[OBJECTIVE] To explore the clinical efficacy of small sub-eyebrow incision in severing the corrugator supercilii muscle combined with autologous block fat transplantation for treating severe frown lines. [METHODOLOGY] Sixteen patients with…
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Vertical inhibition of p110α/AKT and N-cadherin enhances treatment efficacy in PIK3CA-aberrated ovarian cancer cells.
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [PIK3CA, encoding PI3Kalpha (also known as p110α)] is one of the most commonly aberrated genes in human cancers. In serous ovarian cancer, PIK3CA amplification is highly…
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3D Assessment of Mandibular Margin Morphological Change after BTX-A Injection for Masseter Hypertrophy: A Retrospective Study.
[BACKGROUND] Some facial morphological changes may occur in some patients after botulinum toxin A (BTX-A) injection for the treatment of masseteric hypertrophy. The aim of this study was to investigate the morphological changes that occurre…
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Temporal Muscles Thicken Compensatorily After Injection of Botulinum Neurotoxin A Into Masseter Muscles.
The masseter and temporal muscles are primary jaw muscles vital for chewing and speaking, which work in tandem for effective mastication. On the basis of the reported studies that masseter botulinum toxin A injection causes masseter muscle …
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A study protocol for a randomized controlled trial to assess the effects of Baduanjin exercise on balance impairment in patients with cervical dystonia.
[BACKGROUND] Patients with cervical dystonia (CD) commonly exhibit varying degrees of impaired balance, abnormal gait, and increased fear of falling. However, Botulinum toxin-the standard of care-does not substantially improve balance or ga…
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Enhancing Mid-Upper Facial Contours: Hairline Transplant Solutions for East Asian Women With High and Wide Foreheads.
[BACKGROUND] A high and wide forehead is a common congenital facial characteristic among East Asian women, often resulting in an imbalanced mid-upper facial proportion, diminished three-dimensional contour, and reduced femininity. Although …
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LL-MAROCO: A Large Language Model-Assisted Robotic System for Oral and Craniomaxillofacial Osteotomy.
Oral and craniomaxillofacial bone deformities necessitate treatment through osteotomy. Robot-assisted osteotomy appears promising in oral and craniomaxillofacial surgery, but it lacks sufficient intelligence and comprehensive integration of…
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Clinical Application of the High Superficial Musculoaponeurotic System for Facial Rejuvenation in Chinese Patients.
[BACKGROUND] Face lift surgery can improve facial sagging and reestablish a youthful relationship between the soft tissues and the underlying skeleton. The early manifestations of aging in the periorbital region include sagging of the later…
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Muse Cells Orchestrating Renal Repair via Macrophage M2 Polarization in Ischemia-Reperfusion Injury.
Acute renal ischemia-reperfusion injury (IRI) poses significant challenges in clinical management, necessitating the exploration of novel therapeutic strategies. This study investigates the therapeutic potential and underlying mechanisms of…
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Family strategy for nasoalveolar molding in infants with unilateral complete cleft lip and palate.
[BACKGROUND] The aim of the study was to demonstrate the therapeutic outcomes after a family strategy for nasoalveolar molding (Family-NAM) in infants with unilateral complete cleft lip and palate. [METHODS] Forty patients with unilateral …
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Supramastoid Fascia as an Autologous Donor Site Alternative for Moderate Dorsal Augmentation: A Multicenter Prospective Study.
[BACKGROUND] Autologous fascia has been widely applied in rhinoplasty, yet prospective data on the supramastoid donor site remain scarce. This region provides a dense, pliable fascial layer with concealed scarring, potentially suitable for …
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Bacterial Lipoteichoic Acid Induces Capsular Contracture by Activating Innate Immune Response.
[BACKGROUND] Capsular contracture is attributed to an exaggerated fibrosis response within the capsule and is partly associated with bacterial contamination in situ. However, the cellular mechanisms that initiate this response are unclear. …
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The learning curve of the MS-TRAM/DIEP breast reconstruction by dual-trained breast surgeons.
[BACKGROUND] Breast cancer surgeries involving MS-TRAM/DIEP breast reconstruction has traditionally been collaborative efforts between breast surgeons and plastic surgeons. However, in our institution, this procedure is performed by dual-tr…
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Untethered Microgrippers for Precision Medicine.
Microgrippers, a branch of micro/nanorobots, refer to motile miniaturized machines that are of a size in the range of several to hundreds of micrometers. Compared with tethered grippers or other microscopic diagnostic and surgical equipment…
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Favorable effects of open surgery on patients with extensive skull base osteoradionecrosis through a personalized sequential approach: A case series.
The present study aimed to investigate outcomes following open surgery for extensive skull base ORN. Open surgery through a personalized sequential approach was employed to deal with five cases of extensive skull base ORN. Two patients with…
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Association of preoperative aneurysmal wall enhancement with relief of chronic headache after surgical clipping of unruptured intracranial aneurysms.
[OBJECTIVE] To investigate the association between chronic headache outcome and aneurysmal wall enhancement (AWE) on high-resolution vessel wall imaging (HR-VWI) in patients with unruptured intracranial aneurysms (UIAs) who underwent micros…
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Methods and Strategies of Microsurgery Combined with Ilizarov Technique in the Treatment of Amputation of Limbs in Renji Hospital: A Report of 51 Cases.
[OBJECTIVE] Severe limb amputation trauma often results in bone and soft tissue defects after debridement. Traditional replantation aims to save the limb by shortening the ischemic period and using autologous transplantation for repair, but…
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A Study on the Aesthetic Parameters and Proportions of the External Contour for Minimally Invasive Facial Injection.
[OBJECTIVE] The aim of this study was to further guide the diagnosis and treatment programs for clinical facial contouring with injectable fillers by studying the facial contour parameters and proportion preferences consistent with Asian ae…
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Research progress in spasmodic torticollis rehabilitation treatment.
Spasmodic torticollis (ST) is a focal dystonia that affects adults, causing limited muscle control and impacting daily activities and quality of life. The etiology and curative methods for ST remain unclear. Botulinum toxin is widely used a…
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Intradermal Injection in Balding Region Versus Intramuscular Injection in Surrounding Muscles: A Split-Scalp, Randomized Trial on BoNT for Androgenetic Alopecia.
[INTRODUCTION] Recent advancements in androgenetic alopecia (AGA) treatment have highlighted the efficacy of botulinum toxin (BoNT). However, inconsistencies in injection sites and depths warrant attention. It remains unclear which injectio…
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Incarvine C and its analogues inhibit the formation of cell cytoskeleton by targeting Rac1.
Ras-related C3 botulinum toxin substrate 1 (Rac1) has emerged as a key regulator in the treatment of cancer metastasis because of its involvement in the formation of cell plate pseudopods and effects on cell migration. In this study, we fou…
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Surgical Procedures of the Correction of Severe Static Glabellar Lines by Utilizing Resection with Free Dermal Fat Grafting (FDFG).
[BACKGROUND] Botulinum toxin alone is unable to sufficiently reduce the muscle in cases of severe static glabellar lines due to the folded skin and dermal breakdown that frequently accompany these conditions. Augmentation of the soft tissue…
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Development and characterization of a novel neutralizing scFv vectored immunoprophylaxis against botulinum toxin type A.
Botulinum toxin is a protein toxin secreted by Clostridium botulinum that is strongly neurotoxic. Due to its characteristics of being super toxic, quick acting, and difficult to prevent, the currently reported antiviral studies focusing on …