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Multiplex CD30/Carbonic Anhydrase IX Lateral Flow Assay for Rapid Triage of Suspected BIA-ALCL in Peri-implant Seroma Fluid.
[BACKGROUND] Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare lymphoma associated with textured implants. Earlier detection and timely implant/capsulectomy reduce morbidity and improve outcomes. CD30 is a sensit…
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Evidence-Based Steps to Mitigate Bacterial Contamination.
Capsular contracture, the most common complication in breast implant surgery, is primarily driven by bacterial biofilm formation. Risk is influenced by surgical factors such as incision choice, implant placement, and sterility. Textured imp…
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Risk factors for capsular contracture: a study of 91 537 breast implants over 6 years from the Australian Breast Device Registry.
[BACKGROUND] Capsular Contracture (CC) is a key downstream complication of breast implant surgery captured by breast implant registries worldwide. A number of factors have a been linked to CC development including smooth implants and bacter…
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Long-term Outcomes of Poly-4-Hydroxybutyrate (P4HB) in Aesthetic Breast Surgery: An International Experience.
[BACKGROUND] Poly-4-hydroxybutyrate (P4HB), a naturally occurring component of human connective tissue, serves as a biomedically produced thermoplastic polyester scaffold that has been used in many surgical subspecialties. The utilization o…
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Professional Outcomes Following The Aesthetic Society-Endorsed Aesthetic Surgery Fellowships: A Single Program Fellowship Review and National Survey.
[BACKGROUND] The number of The Aesthetic Society-endorsed aesthetic surgery fellowship (ASEAF) programs has grown in recent years as more plastic surgery residents pursue advanced training in aesthetic procedures following residency. [OBJE…
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The Ideal Breast: Insights From a Patient's Survey and a Global Aesthetic Surgery Consensus at the A.M.B.E.R.
The concept of the "ideal breast" in aesthetic surgery has historically varied across regions, with European surgeons favouring more natural outcomes and South American surgeons preferring fuller aesthetics. This study aimed to evaluate whe…
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Multiplex Lateral Flow Assay Combining CD30 and IL-10 for the Detection of BIA-ALCL.
[BACKGROUND] Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) has affected more than 1700 women. Treatment morbidity is reduced and survival improved by early detection and removal of implant and capsule. [OBJECTIVE] To …
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Drivers and Barriers of Breast Augmentation Surgery: Multinational Insights.
[BACKGROUND] Although breast augmentation is generally associated with high levels of patient satisfaction, the number of women undergoing the procedure is low. [OBJECTIVES] To evaluate global key drivers and barriers for women deciding to…
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Preoperative Patient Guidance and Education in Aesthetic Breast Plastic Surgery: A Novel Proposed Application of Artificial Intelligence Large Language Models.
[BACKGROUND] At a time when Internet and social media use is omnipresent among patients in their self-directed research about their medical or surgical needs, artificial intelligence (AI) large language models (LLMs) are on track to represe…
- Commentary on: Plastic Surgeons' Perspective on the FDA Breast Implant Regulatory Mandates.
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CD30 Lateral Flow and Enzyme-Linked Immunosorbent Assays for Detection of BIA-ALCL: A Pilot Study.
[INTRODUCTION] Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) commonly presents as a peri-implant effusion (seroma). CD30 (TNFRSF8) is a consistent marker of tumor cells but also can be expressed by activated lymphocyte…
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Enhancing Patient Outcomes in Aesthetic Breast Implant Procedures Using Proven Antimicrobial Breast Pocket Irrigations: A 20-Year Follow-up.
[BACKGROUND] Capsular contracture (CC) remains the most common complication of implant-based aesthetic and reconstructive breast surgery. With subclinical infection proven to be the primary etiology, antimicrobial breast pocket irrigation h…
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Evaluation of Different Breast Implant Shapes in the Same Patient: Is There Really a Difference between Round and Anatomical Implants?
[BACKGROUND] The choice of the right implant shape is one of the most frequent debates in cosmetic breast augmentation. In current literature, the question of whether there is a difference in the appearance of different implant shapes is st…
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Granzyme B Is a Biomarker for Suspicion of Malignant Seromas Around Breast Implants.
[BACKGROUND] Granzyme B (GrB) is a serine protease secreted, along with pore-forming perforin, by cytotoxic lymphocytes to mediate apoptosis in target cells. GrB has been detected in tumor cells associated with systemic and breast implant-a…
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Gram-Negative Bacterial Lipopolysaccharide Promotes Tumor Cell Proliferation in Breast Implant-Associated Anaplastic Large-Cell Lymphoma.
Breast implant-associated anaplastic large-cell lymphoma (BIA-ALCL) is a distinct malignancy associated with textured breast implants. We investigated whether bacteria could trigger the activation and multiplication of BIA-ALCL cells in vit…
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Is Breast Implant-Associated Anaplastic Large Cell Lymphoma Better Classified as a Lymphoproliferative Disorder and How Surgeons Reduce Risk?
Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a complex topic with evolving classification and etiology. Commonalities between BIA-ALCL and lymphoproliferative disorders exist, suggesting that BIA-ALCL may be better…
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Does Breast Implant-Associated ALCL Begin as a Lymphoproliferative Disorder?
Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) has been included as a provisional entity in the revised version of the World Health Organization Classification of Tumors of Haematopoietic and Lymphoid Tissue. To increas…
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Comparative Analysis of Cytokines of Tumor Cell Lines, Malignant and Benign Effusions Around Breast Implants.
[BACKGROUND] More than 700 women have developed an anaplastic large T cell lymphoma (ALCL) surrounding textured surface breast implants, termed breast implant-associated ALCL (BIA-ALCL). Most patients with BIA-ALCL present with an accumulat…
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Etiology of Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL): Current Directions in Research.
Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a CD30-positive, anaplastic lymphoma kinase-negative T-cell lymphoma. Where implant history is known, all confirmed cases to date have occurred in patients with exposure…
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Optimizing Breast Pocket Irrigation: The Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) Era.
[BACKGROUND] Specific antimicrobial breast pocket irrigations have been proven over the past 20 years to reduce the incidence of capsular contracture by a factor of 10, and the emergence of breast implant-associated anaplastic large cell ly…
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Why Do We Need Anatomical Implants? the Science and Rationale for Maintaining Their Availability and Use in Breast Surgery.
The choice between anatomical and round implants is an important decision in breast augmentation surgery; however, both have their place and the decision between them that should be made on a patient-by-patient basis, taking into account th…
- Effects of COVID-19 on Plastic Surgery Practices and Medi-Spas in Different Countries.
- Discussion: The Epidemiology of Breast Implant-Associated Anaplastic Large Cell Lymphoma in Australia and New Zealand Confirms the Highest Risk for Grade 4 Surface Breast Implants.
- Worldwide Experience of Breast Implant-Associated Large Cell Lymphoma (BIA-ALCL): Expert Panel and Roundtable Discussion.
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Tissue-Based Planning and Technique for Breast Augmentation with Anatomical Implants.
Breast augmentation with anatomical implants offers several potential advantages. Tissue-based planning is patient specific and essential in choosing the correct dimensions of an implant, thereby providing greater control in breast shape fo…
- Discussion: The Questionable Role of Antibiotic Irrigation in Breast Augmentation.
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The Tissue-Based Triad in Augmentation Mastopexy: Single-Stage Technical Refinements.
[BACKGROUND] The number of patients seeking augmentation mastopexy has increased over the last several decades. The conflicting goals of augmentation (tissue expansion) and mastopexy (tissue reduction) have led to higher revision rates, dec…
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MBN 2016 Aesthetic Breast Meeting BIA-ALCL Consensus Conference Report.
Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is an uncommon neoplasia occurring in women with either cosmetic or reconstructive breast implants. The actual knowledge about BIA-ALCL deriving from the literature present…
- Response to "Why the Micromort Concept Falls Short in Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) Risk Analysis".
- Response to "The Micromort Concept and its Applicability to Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) Risk Assessment".