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12건 · 최신순-
Mind the gap: a German case study on the discrepancy between geographic accessibility and real-world utilization of botulinum toxin therapy.
[BACKGROUND] Botulinum toxin A (BoNT-A) is widely used in the treatment of neurological disorders. Despite guideline recommendations, particularly regarding BoNT-A injections for post-stroke spasticity, current evidence shows that many pati…
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Protocol and Demographics of the RELY-CD Study: Assessing Long-Term Clinical Response to Botulinum Neurotoxin in Cervical Dystonia.
The RELY-CD study investigated the long-term clinical response to botulinum neurotoxin type A in cervical dystonia within a multicenter, real-world setting. This retrospective study focused on patients treated with complex-free (incobotulin…
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Systematic Review and Meta-Analysis of Secondary Treatment Failure and Immunogenicity With Botulinum Neurotoxin A in Multiple Indications.
[BACKGROUND] Botulinum neurotoxin A (BoNT-A) is recommended for the treatment of cervical dystonia (CD), spasticity, and blepharospasm. Some patients treated with BoNT-A have been reported to develop neutralizing antibodies (NAbs) against B…
- Botulinum Toxin for Isolated or Essential Head Tremor.
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Significantly lower antigenicity of incobotulinumtoxin than abo- or onabotulinumtoxin.
[BACKGROUND] For many indications, BoNT/A is repetitively injected with the risk of developing neutralizing antibodies (NABs). Therefore, it is important to analyze whether there is a difference in antigenicity between the different license…
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Lessons about Botulinum Toxin A Therapy from Cervical Dystonia Patients Drawing the Course of Disease: A Pilot Study.
[AIM OF THE STUDY] To compare the course of severity of cervical dystonia (CD) before and after long-term botulinum toxin (BoNT) therapy to detect indicators for a good or poor clinical outcome. [PATIENTS AND METHODS] A total of 74 outpati…
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The complex relationship between antibody titers and clinical outcome in botulinum toxin type A long-term treated patients with cervical dystonia.
[BACKGROUND] Repeated injections with abo- or onabotulinumtoxin type A (aboBoNT/A, onaBoNT/A) may lead to induction of neutralizing antibodies (NABs) and/or a secondary treatment failure (STF). The relation between NABs and STF is still unc…
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Long-term adherence and response to botulinum toxin in different indications.
[OBJECTIVE] The objective of the study was the analysis of adherence and self-perceived treatment response to long-term botulinum neurotoxin type A (BoNT-A) treatment in different neurological indications. [METHODS] In this retrospective, …
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Continuous Increase of Efficacy under Repetitive Injections of Botulinum Toxin Type/A beyond the First Treatment for Adult Spastic Foot Drop.
The objective of this study was to quantify the increase in efficacy during the first four cycles of treatment with botulinum toxin type/A (BoNT/A) in 24 free-walking BoNT/A naïve adult patients with post-stroke hemispasticity and spastic f…
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Effective long-term treatment with incobotulinumtoxin (Xeomin®) without neutralizing antibody induction: a monocentric, cross-sectional study.
[BACKGROUND] Among the spectrum of licensed botulinum neurotoxin preparations incobotulinumtoxin (incoBoNT/A; Xeomin®) is the only one which does not contain complex proteins. Therefore, incoBoNT/A has been suggested to have a low antigenic…
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Clinical Implications of Difference in Antigenicity of Different Botulinum Neurotoxin Type A Preparations: Clinical Take-Home Messages from Our Research Pool and Literature.
The three different botulinum toxin type A (BoNT/A) preparations being licensed in Europe and the U.S. differ in protein content, which seems to be a major factor influencing the antigenicity of BoNT/A. In the present study, several argumen…
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Trans-inferior orbital rim anchorage and fascia roll multi-loop temporal anchorage in midface rejuvenation.
[BACKGROUND] A paradigm promoted for midface rejuvenation by Besins in his reverse and repositioning effect (RARE) technique considers 3 vertical sectors of the face. It relies on thread-based suspensions of the malar area and the orbicular…