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6건 · 최신순-
Botulinum Toxin Type A Exerts Direct Trans-Synaptic Action at Bilateral Spinal Nociceptive Circuits.
Botulinum toxin type A (BoNT-A) induces a bilateral analgesic effect following unilateral injection in rodent bilateral or mirror pain models. This occurs either by indirect plasticity-related actions, or by the toxin's direct central actio…
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Botulinum toxin type a antinociceptive activity in trigeminal regions involves central transcytosis.
[OBJECTIVE] Botulinum toxin type A (BoNT-A) provides lasting pain relief in patients with craniofacial pain conditions but the mechanisms of its antinociceptive activity remain unclear. Preclinical research revealed toxin axonal transport t…
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What have we learned about antinociceptive effect of botulinum toxin type A from mirror-image pain models?
Mirror pain represents pain with complex pathophysiological background experienced at both sides of the body, usually after unilateral injury. Although observed almost 10 years ago, the phenomenon of bilateral antinociceptive effect of botu…
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Mechanisms of Botulinum Toxin Type A Action on Pain.
Already a well-established treatment for different autonomic and movement disorders, the use of botulinum toxin type A (BoNT/A) in pain conditions is now continuously expanding. Currently, the only approved use of BoNT/A in relation to pain…
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Role of central versus peripheral opioid system in antinociceptive and anti-inflammatory effect of botulinum toxin type A in trigeminal region.
[BACKGROUND] Although botulinum toxin type A (BT-A) is approved for chronic migraine treatment, its site and mechanism of action are still elusive. Recently our group discovered that suppression of CGRP release from dural nerve endings migh…
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Antinociceptive action of botulinum toxin type A in carrageenan-induced mirror pain.
"Mirror pain" or mirror-image pain (MP) is pain opposite to the side of injury. Mechanism and frequency in humans are not known. There is no consent on therapy. Here we report that unilaterally injected botulinum toxin type A (BT-A) has bil…