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12건 · 최신순-
Excipient substitution in botulinum toxin type A formulations: Insights from multi-scale in silico modelling.
Botulinum neurotoxin type A (BoNT/A) formulations differ mainly in excipients, which determine stability, aggregation, and diffusion. Using multi-scale in silico modelling (AesthetiSIM™), we evaluated excipient substitution across six marke…
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Challenging Interchangeability: Dynamic Dose-Response Modelling of Botulinum Toxin A Products.
[INTRODUCTION] Botulinum Neurotoxin type A (BoNT-A) formulations are used worldwide for both aesthetic and therapeutic indications, yet dose conversion between products remains based on empirical ratios that ignore pharmacodynamic variabili…
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A 15-Year Computational Twin Modeling Study of Botulinum Toxin A Frequency and Age-Related Facial Aging.
[INTRODUCTION] Facial aging results from intrinsic biologic decline and extrinsic environmental influences, producing progressive changes in skin structure, collagen integrity, and soft-tissue support. Botulinum neurotoxin type A (BoNTA) is…
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AI-Enabled Surveillance and Modelling for Counterfeit Botulinum Toxin A: Risk Projection, Patient Safety, and Systemic Reform of Pharmacovigilance.
[BACKGROUND] Counterfeit Botulinum Toxin A (BoNT-A) poses a growing global threat, particularly in aesthetic medicine where regulatory oversight is minimal and underreporting is widespread. Traditional pharmacovigilance systems such as FAER…
- Correction: AI-Enabled Surveillance and Modelling for Counterfeit Botulinum Toxin A: Risk Projection, Patient Safety, and Systemic Reform of Pharmacovigilance.
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When Genes Meet Gels: Computational Immunogenetics of Dermal Fillers and Stratified Risk of Immune and Fibrotic Reactions across Compositions and Genotypes.
[BACKGROUND] Delayed inflammatory and fibrotic reactions to dermal fillers remain unpredictable, reflecting complex interactions between product composition and host genetics. [OBJECTIVE] To develop and validate a computational framework i…
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AI-Driven Insights into Glabellar Wrinkle Patterns: Reassessing the Standardised Botulinum Toxin: An Injection Protocol to Address Anatomical Variability.
[INTRODUCTION] Glabellar wrinkle patterns, a visible manifestation of facial dynamics and ageing, result from complex interactions between anatomical and functional variables such as muscle interdigitation density, skin elasticity, and subc…
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Consensus on Changing Trends, Attitudes, and Concepts of Asian Beauty.
[BACKGROUND] Asians increasingly seek non-surgical facial esthetic treatments, especially at younger ages. Published recommendations and clinical evidence mostly reference Western populations, but Asians differ from them in terms of attitud…
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Consensus on Current Injectable Treatment Strategies in the Asian Face.
[BACKGROUND] The desire for and use of nonsurgical injectable esthetic facial treatments are increasing in Asia. The structural and anatomical features specific to the Asian face, and differences from Western populations in facial aging, ne…
- Commentary on: Effectiveness, Longevity, and Complications of Facelift by Barbed Suture Insertion.
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Facial Assessment and Injection Guide for Botulinum Toxin and Injectable Hyaluronic Acid Fillers: Focus on the Lower Face.
This third article of a three-part series addresses techniques and recommendations for aesthetic treatment of the lower face. The lower face is considered an advanced area for facial aesthetic treatment. In this region, soft-tissue fillers …
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Microbotox of the Lower Face and Neck: Evolution of a Personal Technique and Its Clinical Effects.
Microbotox is the injection of multiple microdroplets of diluted onabotulinumtoxinA into the dermis or the interface between the dermis and the superficial layer of facial muscles. The intention is to decrease sweat and sebaceous gland acti…