Minoxidil: a comprehensive review.
5/5 보강
TL;DR
After 6 months of administration, minoxidil 5 mg/day was significantly more effective than topical 5% and 2% in male AGA, and low-dose 0.5–5 mg/day may also be safe and effective for female pattern hair loss and chronic telogen effluvium.
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
환자: lower sulfotransferase activity
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
Low-dose 0.5-5 mg/day may also be safe and effective for female pattern hair loss and chronic telogen effluvium. Sublingual minoxidil may be safe and effective in male and female pattern hair loss.
📑 코퍼스 인용 관계
· 인용됨 51
📑 인용한 논문 (6) ▾
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- Minoxidil ameliorates myelodysplastic syndrome by targeting Wnt4 while sparing normal hema… Cell communication and signaling : CCS · 2025
연도별 인용 (2021–2026) · 합계 201
OpenAlex 토픽 ·
Hair Growth and Disorders
Dyeing and Modifying Textile Fibers
Dermatologic Treatments and Research
🇰🇷 한글 요약 🌐 Abstract
【연구 목적】
국소 미녹시딜(minoxidil)의 작용기전, 약동학, 용량별 효능, 그리고 경구·설하 투여를 포함한 다양한 제형의 안드로겐성 탈모(androgenetic alopecia, AGA) 및 여성형 탈모(female pattern hair loss), 만성 휴지기 탈모(chronic telogen effluvium) 치료 효과를 종합적으로 검토하기 위함이다.
【방법】
미녹시딜의 약리학적 기전(혈관확장, 항염증, Wnt/β-catenin 신호전달 유도, 항안드로겐 작용), 모낭 내 sulfotransferase에 의한 활성 대사물(minoxidil sulfate) 전환 과정, 그리고 국소(2%·5% 용액, 5% 폼)·경구·설하 제형별 임상 연구 결과를 문헌 고찰 형식으로 정리하였다.
【주요 결과】
국소 도포 시 약 1.4%만이 피부를 통해 흡수되며, sulfotransferase 활성이 높은 환자에서 반응이 더 좋다. 5년 추적 연구에서 2% 미녹시딜은 1년차에 발모 효과가 최고조에 달한 후 점차 감소하였고, 5% 용액·폼은 2%와 효능 차이가 유의하지 않았다. 반면 경구 미녹시딜 5 mg/일은 6개월 시점에 남성 AGA에서 국소 제형보다 유의하게 우수하였고, 저용량(0.5~5 mg/일) 경구 및 설하 투여는 남녀 패턴 탈모와 만성 휴지기 탈모에 안전하고 효과적일 수 있다. 전두측두부(frontotemporal) 및 정수리(vertex) 부위 모두에서 발모 효과가 확인되었다.
【임상적 시사점 (성형외과 의사 관점)】
모발이식 전후 보조요법으로 미녹시딜을 처방할 때, 국소 제형의 효과 정체(plateau) 현상을 환자에게 미리 설명하고, 반응이 불충분한 경우 저용량 경구(0.25~5 mg/일) 또는 설하 미녹시딜로의 전환을 고려할 수 있다. Sulfotransferase 활성 차이로 인한 개인별 반응 편차를 환자 상담 시 강조하고, 5% 제형이 2%보다 반드시 우월하지 않다는 점을 근거로 부작용(자극성 피부염, 다모증) 위험과 균형 잡힌 처방이 필요하다.
Topical minoxidil (5% foam, 5% solution, and 2% solution) is FDA-approved for androgenetic alopecia (AGA) in men and women. Minoxidil acts through multiple pathways (vasodilator, anti-inflammatory agent, inducer of the Wnt/β-catenin signaling pathway, an antiandrogen), and may also affect the length of the anagen and telogen phases. Approximately 1.4% of topical minoxidil is absorbed through the skin. Minoxidil is a prodrug that is metabolized by follicular sulfotransferase to minoxidil sulfate (active form). Those with higher sulfotransferase activity may respond better than patients with lower sulfotransferase activity. In a five-year study, 2% minoxidil exhibited peak hair growth in males at year one with a decline in subsequent years. Topical minoxidil causes hair regrowth in both frontotemporal and vertex areas. The 5% solution and foam were not significantly different in efficacy from the 2% solution. After 6 months of administration, minoxidil 5 mg/day was significantly more effective than topical 5% and 2% in male AGA. Low-dose 0.5-5 mg/day may also be safe and effective for female pattern hair loss and chronic telogen effluvium. Sublingual minoxidil may be safe and effective in male and female pattern hair loss.
【연구 목적】 국소 미녹시딜(minoxidil)의 작용기전, 약동학, 용량별 효능, 그리고 경구·설하 투여를 포함한 다양한 제형의 안드로겐성 탈모(androgenetic alopecia, AGA) 및 여성형 탈모(female pattern hair loss), 만성 휴지기 탈모(chronic telogen effluvium) 치료 효과를 종합적으로 검토하기
APA 7
Gupta, A. K., Talukder, M., Venkataraman, M., & Bamimore, M. A. (2022). Minoxidil: A comprehensive review.. The Journal of dermatological treatment, 33(4), 1896-1906. https://doi.org/10.1080/09546634.2021.1945527
Vancouver
Gupta AK, Talukder M, Venkataraman M, Bamimore MA. Minoxidil: a comprehensive review. Jour. derm. trea.. 2022;33(4):1896-1906. doi:10.1080/09546634.2021.1945527
AMA 11
Gupta AK, Talukder M, Venkataraman M, Bamimore MA. Minoxidil: a comprehensive review. Jour. derm. trea.. 2022;33(4):1896-1906. doi:10.1080/09546634.2021.1945527
Chicago
Gupta, A. K., Talukder, M., Venkataraman, M., and Bamimore, M. A.. 2022. "Minoxidil: a comprehensive review." The Journal of dermatological treatment 33 (4): 1896-1906. https://doi.org/10.1080/09546634.2021.1945527
MLA 9
Gupta, A. K., et al. "Minoxidil: a comprehensive review." The Journal of dermatological treatment, vol. 33, no. 4, 2022, pp. 1896-1906. doi:10.1080/09546634.2021.1945527.
PMID
34159872 ↗
추출된 의학 개체 (NER)
전체 NER 표 보기
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 약물 | minoxidil
|
미녹시딜 | dict | 10 | |
| 질환 | female pattern hair loss
|
여성형 탈모 | dict | 2 | |
| 질환 | androgenetic alopecia
|
안드로겐성 탈모 | dict | 1 | |
| 질환 | telogen effluvium
|
휴지기 탈모 | dict | 1 |
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
인용 관계
그래프 OA 노드: 7/8 (88%)
· 참조 0편 · 후속 7편
이 논문을 인용한 후속 연구 20
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🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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