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Androgen sensitivity gateway to COVID-19 disease severity.

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Drug development research 📖 저널 OA 25.6% 2021: 0/5 OA 2022: 0/3 OA 2023: 0/2 OA 2024: 0/8 OA 2025: 13/28 OA 2026: 7/31 OA 2021~2026 2020 Vol.81(7) p. 771-776 피인용 10회 참고 37건 cited 167 OA RCR 5.87 Dermatological and COVID-19 studies
TL;DR The evidence presented in this communication warrants the initiation of trials using anti‐androgen agents, as the model explains why males are more likely to develop severe symptoms while children are ostensibly resistant to infection.
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PubMed DOI PMC OpenAlex Semantic 마지막 보강 2026-05-06

PICO 자동 추출 (휴리스틱, conf 2/4)

유사 논문
P · Population 대상 환자/모집단
19 patients due to severe symptoms.
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
Androgen sensitivity is a likely determinant of COVID-19 disease severity. We believe that the evidence presented in this communication warrants the initiation of trials using anti-androgen agents.
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연도별 인용 (2020–2026) · 합계 167
OpenAlex 토픽 · Dermatological and COVID-19 studies COVID-19 Clinical Research Studies Diabetes and associated disorders

Wambier CG, Goren A, Vaño-Galván S, Ramos PM, Ossimetha A, Nau G

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Abstract

In this communication, we present arguments for androgen sensitivity as a likely determinant of COVID-19 disease severity. The androgen sensitivity model explains why males are more likely to develop severe symptoms while children are ostensibly resistant to infection. Further, the model explains the difference in COVID-19 mortality rates among different ethnicities. Androgen sensitivity is determined by genetic variants of the androgen receptor. The androgen receptor regulates transcription of the transmembrane protease, serine 2 (TMPRSS2), which is required for SARS-CoV-2 infectivity. TMPRSS2 primes the Spike protein of the virus, which has two consequences: diminishing viral recognition by neutralizing antibodies and activating SARS-CoV-2 for virus-cell fusion. Genetic variants that have been associated with androgenetic alopecia, prostate cancer, benign prostatic hyperplasia and polycystic ovary syndrome could be associated with host susceptibility. In addition to theoretical epidemiological and molecular mechanisms, there are reports of high rates of androgenetic alopecia of from hospitalized COVID-19 patients due to severe symptoms. Androgen sensitivity is a likely determinant of COVID-19 disease severity. We believe that the evidence presented in this communication warrants the initiation of trials using anti-androgen agents.
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The evidence presented in this communication warrants the initiation of trials using anti‐androgen agents, as the model explains why males are more likely to develop severe symptoms while children are

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↓ .bib ↓ .ris
APA 7 Wambier, C. G., Goren, A., S, V., Ramos, P. M., Ossimetha, A., Nau, G., Herrera, S., & McCoy, J. (2020). Androgen sensitivity gateway to covid-19 disease severity.. Drug development research, 81(7), 771-776. https://doi.org/10.1002/ddr.21688
Vancouver Wambier CG, Goren A, S V, Ramos PM, Ossimetha A, Nau G, et al. Androgen sensitivity gateway to COVID-19 disease severity. Drug development research. 2020;81(7):771-776. doi:10.1002/ddr.21688
AMA 11 Wambier CG, Goren A, S V, Ramos PM, Ossimetha A, Nau G, et al. Androgen sensitivity gateway to COVID-19 disease severity. Drug development research. 2020;81(7):771-776. doi:10.1002/ddr.21688
Chicago Wambier, C. G., Goren, A., S, V., Ramos, P. M., Ossimetha, A., Nau, G., Herrera, S., and McCoy, J.. 2020. "Androgen sensitivity gateway to COVID-19 disease severity." Drug development research 81 (7): 771-776. https://doi.org/10.1002/ddr.21688
MLA 9 Wambier, C. G., et al. "Androgen sensitivity gateway to COVID-19 disease severity." Drug development research, vol. 81, no. 7, 2020, pp. 771-776. doi:10.1002/ddr.21688.
PMID 32412125 ↗
DOI 10.1002/ddr.21688

추출된 의학 개체 (NER)

전체 NER 표 보기
유형영어 표현한국어 / 풀이UMLS CUI출처등장
질환 androgenetic alopecia 안드로겐성 탈모 dict 2
질환 androgenetic alopecia 안드로겐성 탈모 dict 2
질환 androgenetic alopecia 안드로겐성 탈모 dict 2
합병증 infection 감염 dict 1
합병증 infection 감염 dict 1
합병증 infection 감염 dict 1

🏷️ 키워드 / MeSH 📖 같은 키워드 OA만

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그래프 OA 노드: 12/12 (100%) · 참조 4편 · 후속 8편

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