Stem cells from human hair follicles: first mechanical isolation for immediate autologous clinical use in androgenetic alopecia and hair loss.
4/5 보강
TL;DR
It is shown that the isolated cells are capable to improve the hair density in patients affected by androgenetic alopecia (AGA) and appear to be located in the bulge area of human.
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
11 patients (38 to 61 years old) affected by AGA in stage 3-5 as determined by the Norwood-Hamilton classification scale.
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
[CONCLUSIONS] We have shown that the isolated cells are capable to improve the hair density in patients affected by androgenetic alopecia (AGA). These cells appear to be located in the bulge area of human.
📑 코퍼스 인용 관계
· 인용됨 42
📑 인용한 논문 (6) ▾
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연도별 인용 (2017–2026) · 합계 142
OpenAlex 토픽 ·
Hair Growth and Disorders
Mesenchymal stem cell research
Hearing, Cochlea, Tinnitus, Genetics
It is shown that the isolated cells are capable to improve the hair density in patients affected by androgenetic alopecia (AGA) and appear to be located in the bulge area of human.
APA
Pietro Gentile, Maria Giovanna Scioli, et al. (2017). Stem cells from human hair follicles: first mechanical isolation for immediate autologous clinical use in androgenetic alopecia and hair loss.. Stem cell investigation, 4, 58. https://doi.org/10.21037/sci.2017.06.04
MLA
Pietro Gentile, et al.. "Stem cells from human hair follicles: first mechanical isolation for immediate autologous clinical use in androgenetic alopecia and hair loss.." Stem cell investigation, vol. 4, 2017, pp. 58.
PMID
28725654 ↗
Abstract 한글 요약
[BACKGROUND] Hair follicles are known to contain a well-characterized niche for adult stem cells: the bulge, which contains epithelial and melanocytic stem cells. Stem cells in the hair bulge, a clearly demarcated structure within the lower permanent portion of hair follicles, can generate the interfollicular epidermis, hair follicle structures, and sebaceous glands. The bulge epithelial stem cells can also reconstitute in an artificial system to a new hair follicle.
[METHODS] In this study, we have developed a new method to isolate human adult stem cells by mechanical centrifugation of punch biopsy from human hair follicles without culture condition. Here, we used human follicle stem cells (HFSCs), to improve the hair density in 11 patients (38 to 61 years old) affected by AGA in stage 3-5 as determined by the Norwood-Hamilton classification scale.
[RESULTS] The primary outcomes were microscopic identification and counting of HFSCs. The secondary outcomes were clinical preliminary results and safety and feasibility in HFSCs-treated scalp. Each scalp tissue suspension contained about 3,728.5±664.5 cells. The percentage of hair follicle-derived mesenchymal stem cells CD44+ [from dermal papilla (DP)] was about 5%+0.7% whereas the percentage of hair follicle epithelial stem cells CD200+ (from the bulge) was about 2.6%+0.3%. In total, 23 weeks after the last treatment with HFSCs mean hair count and hair density increases over baseline values. In particular, a 29%±5% increase in hair density for the treated area and less than a 1% increase in hair density for the placebo area.
[CONCLUSIONS] We have shown that the isolated cells are capable to improve the hair density in patients affected by androgenetic alopecia (AGA). These cells appear to be located in the bulge area of human.
[METHODS] In this study, we have developed a new method to isolate human adult stem cells by mechanical centrifugation of punch biopsy from human hair follicles without culture condition. Here, we used human follicle stem cells (HFSCs), to improve the hair density in 11 patients (38 to 61 years old) affected by AGA in stage 3-5 as determined by the Norwood-Hamilton classification scale.
[RESULTS] The primary outcomes were microscopic identification and counting of HFSCs. The secondary outcomes were clinical preliminary results and safety and feasibility in HFSCs-treated scalp. Each scalp tissue suspension contained about 3,728.5±664.5 cells. The percentage of hair follicle-derived mesenchymal stem cells CD44+ [from dermal papilla (DP)] was about 5%+0.7% whereas the percentage of hair follicle epithelial stem cells CD200+ (from the bulge) was about 2.6%+0.3%. In total, 23 weeks after the last treatment with HFSCs mean hair count and hair density increases over baseline values. In particular, a 29%±5% increase in hair density for the treated area and less than a 1% increase in hair density for the placebo area.
[CONCLUSIONS] We have shown that the isolated cells are capable to improve the hair density in patients affected by androgenetic alopecia (AGA). These cells appear to be located in the bulge area of human.
추출된 의학 개체 (NER)
전체 NER 표 보기
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 해부 | hair follicle
|
모낭 | dict | 4 | |
| 해부 | hair follicle
|
모낭 | dict | 4 | |
| 해부 | scalp
|
두피 | dict | 2 | |
| 해부 | scalp
|
두피 | dict | 2 | |
| 질환 | androgenetic alopecia
|
안드로겐성 탈모 | dict | 2 |
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
인용 관계
그래프 OA 노드: 8/8 (100%)
· 참조 0편 · 후속 8편
이 논문을 인용한 후속 연구 20
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- PI3K/Akt signaling pathway is essential for de novo hair follicle regeneration.
- Platelet-Rich Plasma and Micrografts Enriched with Autologous Human Follicle Mesenchymal Stem Cells …
- Autologous Cellular Method Using Micrografts of Human Adipose Tissue Derived Follicle Stem Cells in …
- A randomized, double-blind, vehicle-controlled clinical study of hair regeneration using adipose-der…
- Autologous Micrografts from Scalp Tissue: Trichoscopic and Long-Term Clinical Evaluation in Male and…
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- Advancing Regenerative Cellular Therapies in Non-Scarring Alopecia.
- Hydrogel forming microneedles loaded with VEGF and Ritlecitinib/polyhydroxyalkanoates nanoparticles …
- Advances in Stem Cell-Based Therapy for Hair Loss.
- Status of research on the development and regeneration of hair follicles.
- Stem cell secretome as a mechanism for restoring hair loss due to stress, particularly alopecia area…
- Cell Therapy for Androgenetic Alopecia: Elixir or Trick?
- Hair Loss and Telogen Effluvium Related to COVID-19: The Potential Implication of Adipose-Derived Me…
- Human Stem Cell Use in Androgenetic Alopecia: A Systematic Review.
- Advanced Medical Therapies in the Management of Non-Scarring Alopecia: Areata and Androgenic Alopeci…
- Early-onset androgenetic alopecia in China: a descriptive study of a large outpatient cohort.
- Exosomes Derived from Dermal Papilla Cells Mediate Hair Follicle Stem Cell Proliferation through the…
같은 제1저자의 인용 많은 논문 (5)
- Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt pathway, Growth-Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development.
- The Effect of Platelet-Rich Plasma in Hair Regrowth: A Randomized Placebo-Controlled Trial.
- Evaluation of Not-Activated and Activated PRP in Hair Loss Treatment: Role of Growth Factor and Cytokine Concentrations Obtained by Different Collection Systems.
- Systematic Review of Platelet-Rich Plasma Use in Androgenetic Alopecia Compared with Minoxidil, Finasteride, and Adult Stem Cell-Based Therapy.
- Platelet-Rich Plasma and Micrografts Enriched with Autologous Human Follicle Mesenchymal Stem Cells Improve Hair Re-Growth in Androgenetic Alopecia. Biomolecular Pathway Analysis and Clinical Evaluation.
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
📖 비슷한 OA 논문 — 같은 카테고리, 무료 전문 가능
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