Human epithelial hair follicle stem cells and their progeny: current state of knowledge, the widening gap in translational research and future challenges.
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TL;DR
How human eHFSCs may be selectively targeted experimentally and their immediate progeny and their molecular markers are reviewed, to transfer emerging concepts from murine epithelial stem cell biology to human HF physiology and pathology.
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연도별 인용 (2014–2026) · 합계 140
OpenAlex 토픽 ·
Hair Growth and Disorders
Skin and Cellular Biology Research
melanin and skin pigmentation
How human eHFSCs may be selectively targeted experimentally and their immediate progeny and their molecular markers are reviewed, to transfer emerging concepts from murine epithelial stem cell biology
APA
Talveen S. Purba, Iain S. Haslam, et al. (2014). Human epithelial hair follicle stem cells and their progeny: current state of knowledge, the widening gap in translational research and future challenges.. BioEssays : news and reviews in molecular, cellular and developmental biology, 36(5), 513-25. https://doi.org/10.1002/bies.201300166
MLA
Talveen S. Purba, et al.. "Human epithelial hair follicle stem cells and their progeny: current state of knowledge, the widening gap in translational research and future challenges.." BioEssays : news and reviews in molecular, cellular and developmental biology, vol. 36, no. 5, 2014, pp. 513-25.
PMID
24665045 ↗
Abstract 한글 요약
Epithelial hair follicle stem cells (eHFSCs) are required to generate, maintain and renew the continuously cycling hair follicle (HF), supply cells that produce the keratinized hair shaft and aid in the reepithelialization of injured skin. Therefore, their study is biologically and clinically important, from alopecia to carcinogenesis and regenerative medicine. However, human eHFSCs remain ill defined compared to their murine counterparts, and it is unclear which murine eHFSC markers really apply to the human HF. We address this by reviewing current concepts on human eHFSC biology, their immediate progeny and their molecular markers, focusing on Keratin 15 and 19, CD200, CD34, PHLDA1, and EpCAM/Ber-EP4. After delineating how human eHFSCs may be selectively targeted experimentally, we close by defining as yet unmet key challenges in human eHFSC research. The ultimate goal is to transfer emerging concepts from murine epithelial stem cell biology to human HF physiology and pathology.
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이 논문을 인용한 후속 연구 20
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같은 제1저자의 인용 많은 논문 (5)
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