Wnt signaling, lgr5, and stem cells in the intestine and skin.
4/5 보강
TL;DR
A comprehensive overview of the stem cell compartments in the intestine and skin with a focus on the cycling, yet long-lived and multipotent, Lgr5(+ve) stem cell populations is provided.
📑 코퍼스 인용 관계
· 인용됨 4
📑 인용한 논문 (4) ▾
- Effects of silybin on triptorelin-induced bone metabolic abnormalities in prostate cancer … PloS one · 2026
- Loss of PRC1 activity in different stem cell compartments activates a common transcription… Science advances · 2019
- Distinct expression profile of stem cell markers, LGR5 and LGR6, in basaloid skin tumors. Virchows Archiv : an international journal of pathology · 2017
- Partial maintenance and long-term expansion of murine skin epithelial stem cells by Wnt-3a… The Journal of investigative dermatology · 2015
연도별 인용 (2012–2026) · 합계 277
OpenAlex 토픽 ·
Hair Growth and Disorders
Wnt/β-catenin signaling in development and cancer
Cancer Cells and Metastasis
Abstract 🌐 Abstract
Stem cells hold great promise for regenerative medicine, but have remained elusive in many tissues because of a lack of adequate definitive markers. Progress in mouse genetics has provided the tools for characterization and validation of stem cell markers by functional and/or lineage tracing assays. The Wnt target gene Lgr5 has been recently identified as a novel stem cell marker of the intestinal epithelium and the hair follicle. In the intestine, Lgr5 is exclusively expressed in cycling crypt base columnar cells. Genetic lineage-tracing experiments revealed that crypt base columnar cells are capable of self-renewal and multipotency, thus representing genuine intestinal stem cells. In the stem cell niche of the murine hair follicle, Lgr5 is expressed in actively cycling cells. Transplantation and lineage tracing experiments have demonstrated that these Lgr5(+ve) cells maintain all cell lineages of the hair follicle throughout long periods of time and can build entire new hair follicles. Expression of Lgr5 in multiple other organs indicates that it may represent a global marker of adult stem cells. This review attempts to provide a comprehensive overview of the stem cell compartments in the intestine and skin with a focus on the cycling, yet long-lived and multipotent, Lgr5(+ve) stem cell populations.
A comprehensive overview of the stem cell compartments in the intestine and skin with a focus on the cycling, yet long-lived and multipotent, Lgr5(+ve) stem cell populations is provided.
APA 7
Haegebarth, A., & Clevers, H. (2009). Wnt signaling, lgr5, and stem cells in the intestine and skin.. The American journal of pathology, 174(3), 715-21. https://doi.org/10.2353/ajpath.2009.080758
Vancouver
Haegebarth A, Clevers H. Wnt signaling, lgr5, and stem cells in the intestine and skin. Amer. jour. path.. 2009;174(3):715-21. doi:10.2353/ajpath.2009.080758
AMA 11
Haegebarth A, Clevers H. Wnt signaling, lgr5, and stem cells in the intestine and skin. Amer. jour. path.. 2009;174(3):715-21. doi:10.2353/ajpath.2009.080758
Chicago
Haegebarth, A., and Clevers, H.. 2009. "Wnt signaling, lgr5, and stem cells in the intestine and skin." The American journal of pathology 174 (3): 715-21. https://doi.org/10.2353/ajpath.2009.080758
MLA 9
Haegebarth, A., and Clevers H. "Wnt signaling, lgr5, and stem cells in the intestine and skin." The American journal of pathology, vol. 174, no. 3, 2009, pp. 715-21. doi:10.2353/ajpath.2009.080758.
PMID
19197002 ↗
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
인용 관계
그래프 OA 노드: 3/4 (75%)
· 참조 0편 · 후속 3편
이 논문을 인용한 후속 연구 4
- Loss of PRC1 activity in different stem cell compartments activates a common transcriptional program…
- Partial maintenance and long-term expansion of murine skin epithelial stem cells by Wnt-3a in vitro.
- Distinct expression profile of stem cell markers, LGR5 and LGR6, in basaloid skin tumors.
- Effects of silybin on triptorelin-induced bone metabolic abnormalities in prostate cancer revealed b…