A crucial role for Fgfr2-IIIb signalling in epidermal development and hair follicle patterning.
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TL;DR
Results suggest that Fgf signalling positively regulates the number of keratinocytes needed to form a normal stratified epidermis and to initiate hair placode formation, and in addition, F gf signals are required for the growth and patterning of pelage hairs.
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연도별 인용 (2012–2026) · 합계 108
OpenAlex 토픽 ·
Hair Growth and Disorders
Cancer and Skin Lesions
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Abstract 🌐 Abstract
To understand the role Fgf signalling in skin and hair follicle development, we analysed the phenotype of mice deficient for Fgfr2-IIIb and its main ligand Fgf10. These studies showed that the severe epidermal hypoplasia found in mice null for Fgfr2-IIIb is caused by a lack of the basal cell proliferation that normally results in a stratified epidermis. Although at term the epidermis of Fgfr2-IIIb null mice is only two to three cells thick, it expresses the classical markers of epidermal differentiation and establishes a functional barrier. Mice deficient for Fgf10 display a similar but less severe epidermal hypoplasia. By contrast, Fgfr2-IIIb-/-, but not Fgf10-/-, mice produced significantly fewer hair follicles, and their follicles were developmentally retarded. Following transplantation onto nude mice, grafts of Fgfr2-IIIb-/- skin showed impaired hair formation, with a decrease in hair density and the production of abnormal pelage hairs. Expression of Lef1, Shh and Bmp4 in the developing hair follicles of Fgfr2-IIIb-/- mice was similar to wild type. These results suggest that Fgf signalling positively regulates the number of keratinocytes needed to form a normal stratified epidermis and to initiate hair placode formation. In addition, Fgf signals are required for the growth and patterning of pelage hairs.
Results suggest that Fgf signalling positively regulates the number of keratinocytes needed to form a normal stratified epidermis and to initiate hair placode formation, and in addition, F gf signals
APA 7
Petiot, A., Conti, F. J., Grose, R., Revest, J. M., Hodivala-Dilke, K. M., & Dickson, C. (2003). A crucial role for fgfr2-iiib signalling in epidermal development and hair follicle patterning.. Development (Cambridge, England), 130(22), 5493-501. https://doi.org/10.1242/dev.00788
Vancouver
Petiot A, Conti FJ, Grose R, Revest JM, Hodivala-Dilke KM, Dickson C. A crucial role for Fgfr2-IIIb signalling in epidermal development and hair follicle patterning. Deve. (Cam. Engl.. 2003;130(22):5493-501. doi:10.1242/dev.00788
AMA 11
Petiot A, Conti FJ, Grose R, Revest JM, Hodivala-Dilke KM, Dickson C. A crucial role for Fgfr2-IIIb signalling in epidermal development and hair follicle patterning. Deve. (Cam. Engl.. 2003;130(22):5493-501. doi:10.1242/dev.00788
Chicago
Petiot, A., Conti, F. J., Grose, R., Revest, J. M., Hodivala-Dilke, K. M., and Dickson, C.. 2003. "A crucial role for Fgfr2-IIIb signalling in epidermal development and hair follicle patterning." Development (Cambridge, England) 130 (22): 5493-501. https://doi.org/10.1242/dev.00788
MLA 9
Petiot, A., et al. "A crucial role for Fgfr2-IIIb signalling in epidermal development and hair follicle patterning." Development (Cambridge, England), vol. 130, no. 22, 2003, pp. 5493-501. doi:10.1242/dev.00788.
PMID
14530295 ↗
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
인용 관계
그래프 OA 노드: 8/8 (100%)
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