Stem cells of the skin epithelium.
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TL;DR
Difficult to identify and characterize in any tissue, these cells are nonetheless hotly pursued because they hold the potential promise of therapeutic reprogramming to grow human tissue in vitro, for the treatment of human disease.
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📑 인용한 논문 (5) ▾
- Regulation of stem cell fate by HSPGs: implication in hair follicle cycling. NPJ Regenerative medicine · 2022
- Basal Cells in the Epidermis and Epidermal Differentiation. Stem cell reviews and reports · 2022
- SIRT7 activates quiescent hair follicle stem cells to ensure hair growth in mice. The EMBO journal · 2020
- Notch signaling is significantly suppressed in basal cell carcinomas and activation induce… Molecular medicine reports · 2017
- Protection against chemotherapy-induced alopecia. Pharmaceutical research · 2006
연도별 인용 (2012–2026) · 합계 206
OpenAlex 토픽 ·
Wound Healing and Treatments
Pluripotent Stem Cells Research
Mesenchymal stem cell research
Abstract 🌐 Abstract
Tissue stem cells form the cellular base for organ homeostasis and repair. Stem cells have the unusual ability to renew themselves over the lifetime of the organ while producing daughter cells that differentiate into one or multiple lineages. Difficult to identify and characterize in any tissue, these cells are nonetheless hotly pursued because they hold the potential promise of therapeutic reprogramming to grow human tissue in vitro, for the treatment of human disease. The mammalian skin epithelium exhibits remarkable turnover, punctuated by periods of even more rapid production after injury due to burn or wounding. The stem cells responsible for supplying this tissue with cellular substrate are not yet easily distinguishable from neighboring cells. However, in recent years a significant body of work has begun to characterize the skin epithelial stem cells, both in tissue culture and in mouse and human skin. Some epithelial cells cultured from skin exhibit prodigious proliferative potential; in fact, for >20 years now, cultured human skin has been used as a source of new skin to engraft onto damaged areas of burn patients, representing one of the first therapeutic uses of stem cells. Cell fate choices, including both self-renewal and differentiation, are crucial biological features of stem cells that are still poorly understood. Skin epithelial stem cells represent a ripe target for research into the fundamental mechanisms underlying these important processes.
Difficult to identify and characterize in any tissue, these cells are nonetheless hotly pursued because they hold the potential promise of therapeutic reprogramming to grow human tissue in vitro, for
APA 7
Alonso, L., & Fuchs, E. (2003). Stem cells of the skin epithelium.. Proceedings of the National Academy of Sciences of the United States of America, 100 Suppl 1(Suppl 1), 11830-5. https://doi.org/10.1073/pnas.1734203100
Vancouver
Alonso L, Fuchs E. Stem cells of the skin epithelium. Proc. Nati. Acad. Scie. Unit. Stat. Amer.. 2003;100 Suppl 1(Suppl 1):11830-5. doi:10.1073/pnas.1734203100
AMA 11
Alonso L, Fuchs E. Stem cells of the skin epithelium. Proc. Nati. Acad. Scie. Unit. Stat. Amer.. 2003;100 Suppl 1(Suppl 1):11830-5. doi:10.1073/pnas.1734203100
Chicago
Alonso, L., and Fuchs, E.. 2003. "Stem cells of the skin epithelium." Proceedings of the National Academy of Sciences of the United States of America 100 Suppl 1 (Suppl 1): 11830-5. https://doi.org/10.1073/pnas.1734203100
MLA 9
Alonso, L., and Fuchs E. "Stem cells of the skin epithelium." Proceedings of the National Academy of Sciences of the United States of America, vol. 100 Suppl 1, no. Suppl 1, 2003, pp. 11830-5. doi:10.1073/pnas.1734203100.
PMID
12913119 ↗
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
인용 관계
그래프 OA 노드: 3/5 (60%)
· 참조 0편 · 후속 3편
이 논문을 인용한 후속 연구 5
- Protection against chemotherapy-induced alopecia.
- SIRT7 activates quiescent hair follicle stem cells to ensure hair growth in mice.
- Regulation of stem cell fate by HSPGs: implication in hair follicle cycling.
- Basal Cells in the Epidermis and Epidermal Differentiation.
- Notch signaling is significantly suppressed in basal cell carcinomas and activation induces basal ce…